Mefenamic acid-induced bilateral transient myopia, secondary angle closure glaucoma and choroidal detachment

Abstract

Drug-induced secondary angle closure is quite common and in the majority of cases simply stopping the medication leads to rapid reversal of the condition and resolution of glaucoma. We describe here a patient who presented with secondary angle closure glaucoma and myopia following mefenamic acid ingestion which was managed successfully by stopping the medication, symptomatic treatment and reassurance.

Angiographic features of drug-induced bilateral angle closure and transient myopia with Ciliochoroidal effusion

“…Cases 3, 4 and 5 also have resulted from exposure to these sulfonamide-containing drugs and case 4 was reported as case report in our previous article [8]. Recently, Vishwakarma et al [11] reported a case of transient myopia and angle closure glaucoma after mefenamic acid medication. The case 1 patient is the second report of angle closure and transient myopia induced by mefenamic acid ingestion.…”

“…Bilateral angle closure glaucoma with ciliochoroidal effusion and transient myopia is a well-known complication of sulfa drugs such as topiramate [1–3], hydrochlorothiazide [4–6], acetazolamide [6, 7], methazolamide [8, 9], and indapamide [10]. Recently, cases of bilateral angle closure glaucoma and transient myopia with ciliochoroidal effusion induced by mefenamic acid [11] or anorexiants, including phendimetrazine tartrate and ephedrine [12], have been reported. For drug-induced angle closure glaucoma with ciliochoroidal effusion, there is no known report of angiographic findings, including indocyanine green angiography (ICGA), although the main pathology of this condition is thought to be associated with alterations of the ciliochoroidal layer.…”

Plasmonic Nanostructures for Biomedical and Sensing Applications

“…Raman scattering by a molecule, first observed in 1928 [48,49], is an inelastic process wherein the energy of the [41] and (e-i) [42]) scattered photon ( E sca ) is different from that of the absorbed photon ( E abs ). This energy difference, known as Raman shift, corresponds to changes in the vibrational state of the molecule, and can be classified as Stokes shift ( E sca < E abs ) or anti-Stokes shift ( E sca > E abs ) (Fig.…”

Comment on: Bilateral angle closure glaucoma: Differential diagnosis

“…Hyperglycemia (diabetes) may cause changes in refractive error by similar mechanism. [ 3 ] Physical exercise may cause increased choroidal thickness. [ 4 ]…”