Meeting the challenge of antibiotic resistance

Cars, Otto; Högberg, Liselotte Diaz; Murray, Mary; Nordberg, Olle; Sivaraman, S.; Lundborg, Cecilia Stålsby; So, Anthony D.; Tomson, Göran

doi:10.1136/bmj.a1438

Cited by 177 publications

(151 citation statements)

References 26 publications

Supporting

Mentioning

148

Contrasting

Unclassified

Order By: Relevance

“…Several reports from the scientific studies raised their concerns about the antibiotic resistant strain of bacteria and the limitation on the adequate knowledge improvisation during drug designing (7,(16)(17)(18)(19). Among the various reasons, free supply and manufacture of antimicrobials, reduced antimicrobial therapy, insufficient access to effectual drugs and sometimes drugs of doubtful quality and overall poverty may play role in the development of antimicrobial resistance (20).…”

Section: Resultsmentioning

confidence: 99%

Antimicrobial potency assay of common antibiotics collected from different drug stores in Dhaka Metropolis

et al. 2015

View full text Add to dashboard Cite

26Antibiotic, known as the magic bullet, was developed to control the growth of pathogenic bacteria. Efficacy of an antibiotic depends on its target site on bacteria. The current public health issue is the emergence of resistant bacterial strains against these drugs. The present study was undertaken to perform the routine antibiotic susceptibility pattern of eight laboratory isolates (Escherichia coli, Bacillus spp., Staphylococcus spp., Vibrio spp., Salmonella spp., Pseudomonas spp., Klebsiella spp. and Listeria spp.) against eleven different categories of antibiotics (Ciprofloxacin, Cephradine, Metronidazole, Cefuroxime, Cefixime, Levofloxacin, Amoxicillin, Azithromycin, Doxycycline, Erythromycin and Flucloxacillin) available in local markets of Dhaka metropolis. Among these antibiotics, Azithromycin, Ciprofloxacin, Cefuroxime, Levofloxacin and Doxycycline showed the highest potency against these bacteria. On the contrary, Amoxicillin and Metronidazole showed almost no potency. Erythromycin, Cephradine and Flucloxacillin gave variable effectivity against the tested isolates. These findings reveal that measures for prevention and containment of antimicrobial resistance are necessary in Bangladesh.

show abstract

Section: Resultsmentioning

confidence: 99%

Antimicrobial potency assay of common antibiotics collected from different drug stores in Dhaka Metropolis

et al. 2015

View full text Add to dashboard Cite

show abstract

“…Emergence of multidrug-resistant (MDR) microorganism infections has generated considerable attention in recent decades (Boucher et al 2008; Cars et al 2008). Antibiotic resistance is one of the greatest challenges facing modern medicine (Spellberg et al 2008).…”

Section: Introductionmentioning

confidence: 99%

Molecular profiling and antimicrobial potential of endophyticGliomastix polychromaCLB32 inhabitingCombretum latifoliumBlume

et al. 2015

View full text Add to dashboard Cite

Fungal endophytes as a source of bioactive metabolites have led to the development of pharmaceutical products finding new applications. In a survey of endophytic fungal biodiversity, an antimicrobial endophytic strain CLB32 was isolated from the leaf of Combretum latifolium Blume (Combretaceae) from the Western Ghats of Southern India. CLB32 was then identified as Gliomastix polychroma (KR704576) by morphological and phylogenetic analysis based on internal transcribed spacer (ITS) nuclear rDNA and intervening 5.8S rRNA gene. CLB32 here constituted the first report on incidence of endophytic fungi from C. latifolium Blume. Ethyl acetate fraction of strain CLB32 was evaluated for antimicrobial activity by disc diffusion assay. Secondary metabolites produced effectively inhibited methicillin-resistant Staphylococcus aureus (18.33 ± 0.33 mm), Pseudomonas aeruginosa (14.66 ± 0.33 mm) and Candida albicans (14.00 ± 0.57 mm). Biosynthesis of these antimicrobial compounds was detected by analytical TLC-bioautography method as depicted by zone of inhibition on intensive the band. These findings suggest that G. polychroma CLB32, as a producer of natural antimicrobial drugs, could help to combat against multidrug-resistant infections and also provide baseline information for industrial applications.

show abstract

“…Extensive clinical use of antibiotics in both human and veterinary medicine has been blamed for the rise and spread of antibiotic-resistant (AR) bacteria (11). But, in recent years, several reports have raised concerns that antibacterial drug development will not adequately address the problems posed by antibiotic resistance among important bacterial pathogens (12)(13)(14)(15). However, the widespread use of antibiotics in animals as well as human beings has resulted in the frequent detection of antibiotic-resistant bacteria in human waste, meat, fish farms, rivers, and lakes (16,17).…”

Section: Introductionmentioning

confidence: 99%

Investigating the Resistance of Escherichia coli Against Some Selected Antimicrobials in Bam

Ayatollahi¹,

Vahidi²,

Shahcheraghi³

et al. 2013

Jundishapur J Microbiol

View full text Add to dashboard Cite

Background: Antibiotics and corresponding resistance genes and resistant bacteria have been considered as emerging pollutants worldwide. Excessive and incorrect use of antimicrobials in human and veterinary medicine, as well as their metaphylactic application in livestock are considered to be key aspects of this current situation. Objectives: The current study aimed to investigate the resistance of Escherichia coli against six antibiotics, in Bam. Materials and Methods: This descriptive study was performed on 300 samples with positive cultures of E. coli in 2006-2007 at the Central Laboratory and the Pasteur hospital in Bam city. Information related to this study was first collected by visiting the above laboratories and completing questionnaires and then recorded in the Excel program and analyzed using the SPSS software and chi-square statistical method. Results: In this study, high resistances were found to nalidixic acid (59.7%) and gentamicin (52.3%) but high susceptibilities were found to ciprofloxacin (59.3%) and ceftriaxone (36.3%). Conclusions: According to the results obtained in this study ciprofloxacin is an effective antibiotic in E.coli infections.

show abstract

Meeting the challenge of antibiotic resistance

Abstract: A concerted global response is needed to tackle rising rates of antibiotic resistance, say Otto Cars and colleagues

Cited by 177 publications

References 26 publications

Antimicrobial potency assay of common antibiotics collected from different drug stores in Dhaka Metropolis

Antimicrobial potency assay of common antibiotics collected from different drug stores in Dhaka Metropolis

Molecular profiling and antimicrobial potential of endophyticGliomastix polychromaCLB32 inhabitingCombretum latifoliumBlume

Investigating the Resistance of Escherichia coli Against Some Selected Antimicrobials in Bam

Contact Info

Product

Resources

About