Medulloblastomas with Distant Metastases

Oberman, Harold A.; Hewitt, Wilmer C.; Kalivoda, J

doi:10.1093/ajcp/39.2.148

Cited by 48 publications

(8 citation statements)

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“…Oberman et al . [5] considered the role of perineural lymphatics, whereas Mccomb et al . [6] in a report of two cases with metastatic soft tissue mass at neck suggested direct spread as a possibility in their group.…”

Section: Discussionmentioning

confidence: 99%

Subcutaneous metastasis in medulloblastoma: A case report and review of literature

et al. 2013

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Extraneural metastasis (ENM) in patients with medulloblastoma is a rare but a well-described phenomenon, both in children and adults. Most of the ENM involve bone and bone marrow and rarely involve other solid organs. Subcutaneous and muscular metastasis is an extremely rare event, more so in children, with only two cases documented in the pediatric population. We describe a case of medulloblastoma with ENM in right masseter and subcutaneous plane along with concomitant central nervous system relapse, 4 years after the primary diagnosis, with a brief review of the literature.

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Section: Discussionmentioning

confidence: 99%

Subcutaneous metastasis in medulloblastoma: A case report and review of literature

et al. 2013

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“…Additionally, recurrence in the surgical suture line, a prominent fea-ture in this instance, has rarely been reported by other investigators. 32 In several pediatrie tumors, including medulloblastomas, the presence of DNA aneuploidy is associated with better patient survival than is the presence of DNA diploidy.9•33 •34 The ploidy pattern of the aggressive tumor in our patient, however, was aneuploid, a situation reminiscent of adult tumors at extraneural sites wherein aneuploidy correlates with a poor outcome.35 •36 Although cytogenetic data on medulloblastoma are not as abundant as those for other brain tumors, such as glioblastomas,27 karyotypic abnormalities have been described by several investigators. "•37 Alterations of the short arm of chromosome 17 are observed in 30% of medulloblastomas and are the most frequent chromosomal abnormality in medulloblastoma.…”

Section: Discussionmentioning

confidence: 99%

Aggressive Medulloblastoma With High-Level N-myc Amplification

Tomlinson

Jenkins

Scheithauer

et al. 1994

Mayo Clinic Proceedings

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A 27-year-old man was treated for an aggressive cerebellar medulloblastoma that, at operation, exhibited dural invasion. Six months after gross total resection and radiation therapy, a "surgical metastasis" developed in the lower portion of the surgical scar. The tumor grew rapidly down into the right side of his neck. Chemotherapy failed, and he subsequently died. Cytogenetic and molecular genetic studies revealed multiple numeric and structural chromosome abnormalities, including an abnormal chromosome 17p arm, more than 100-fold N-myc amplification, a rearranged c-myc gene, and a 16-base pair deletion involving exon 7 of the p53 gene. We postulate that these genetic features may have contributed to the aggressive behavior of the tumor.

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“…The review of the literature reveals an increasing tendency towards permanent shunting in the management of posterior fossa tumors. Metastasis via implanted shunts used to be an extremely rare observation, but appears to occur more often in recent years (3,4,6,7,10,11,13,14,16,22,24). The number of reported cases, which may not even represent the total amount, justifies a serious reflection a. bout this procedure.…”

Section: Discussionmentioning

confidence: 99%

Shunt Metastases in Posterior Fossa Tumors

Oberbauer¹,

Tritthart²,

Ascher³

et al. 1979

Neuropediatrics

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Permanent (CSF-drainages for treatment of hydrocephalus in posterior fossa tumors have been used in the last few years, increasingly. The rare incidence of extracranial metastases and it's higher frequency in the same period of time has been remarkable. An additional case of metastasis via ventriculoperitoneal shunt is presented. Such deleterious complications of malignant CNS-tumors should be avoided, as progressively improving results with combined radio-chemotherapy have established a more encouraging prognosis.

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Medulloblastomas with Distant Metastases

Cited by 48 publications

References 0 publications

Subcutaneous metastasis in medulloblastoma: A case report and review of literature

Subcutaneous metastasis in medulloblastoma: A case report and review of literature

Aggressive Medulloblastoma With High-Level N-myc Amplification

Shunt Metastases in Posterior Fossa Tumors

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