Subcutaneous metastasis in medulloblastoma: A case report and review of literature

BackgroundExtraneural metastases (ENM) rarely occur in medulloblastoma (MBL) patients and only few cases of subcutaneous localizations have been described. ENM indicate an aggressive disease associated with a worse prognosis. The characterization of metastatic tumours might be useful to understand their pathogenesis and to identify the most appropriate therapeutic strategies.Case presentationWe present the case of a child with Large Cell Anaplastic (LC/A) MBL, who developed multiple subcutaneous metastases in the scalp area after a ventriculo-peritoneal shunting procedure. The disease rapidly progressed and the child died despite chemotherapy and primary tumour surgical debulking.We molecularly classified the tumour as a group 3 MBL; in addition, we derived stem-like cells (SLC) from a metastatic lesion. Primary tumour, metastases and SLC were further analysed, particularly focusing on features linked to the cutaneous dissemination. Indeed, molecules involved in angiogenesis, cell invasion and epidermal growth factor signalling resulted highly expressed.ConclusionsThe present report describes a very rare case of subcutaneous metastatic MBL. The tumour, metastases and SLC have been clinically, pathologically and molecularly characterized. Our case is an example of multidisciplinary approach aiming to characterize MBL aggressive behaviour.

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“…Subcutaneous metastases have been reported in very few cases [ 5 , 6 ]. Our clinical report is the first in a well-documented LC/A MBL.…”

Section: Discussionmentioning

confidence: 99%

“…Brain and spine secondary localizations are frequent, while extraneural metastases (ENM) are rare (<10% of cases) and occur mostly in bone, lymph nodes, lung and liver [ 4 ]. Subcutaneous ENM have been described in very few cases [ 5 , 6 ].…”

Section: Introductionmentioning

confidence: 99%

Large cell anaplastic medulloblastoma metastatic to the scalp: tumor and derived stem-like cells features

et al. 2014

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“…Article published online: 2023-09-27 extraneural metastasis is 7 to 10%. 1 Most common sites are bone, bone marrow, lymph nodes, lung, and liver. 2 The mechanisms of spread are due to perineural lymphatics and by direct seeding.…”

Section: Fundingmentioning

confidence: 99%

Medulloblastoma with Subcutaneous Spread: A Rare Entity

Srinivasan,

Hegde,

Nair

et al. 2023

Asian J Neurosurg

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Medulloblastoma is the most common malignant pediatric brain tumor. Histological subclassification and adjuvant therapy have improved prognostication and outcome. Extraneural metastasis remains a poor prognostic factor and subcutaneous seeding is rarely encountered and reported in the pediatric population. We report a 3-year-old child who rapidly presented with subcutaneous seeding a month following gross total resection of his tumor.

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Recommandations pour le don d’organes issus de patients porteurs de tumeurs primitives cérébrales ou médullaires de la part de l’Association des neuro-oncologues d’expression française (ANOCEF) et le Club de neuro-oncologie de la Société française de neurochirurgie

et al. 2017

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Subcutaneous metastasis in medulloblastoma: A case report and review of literature

Cited by 5 publications

References 5 publications

Large cell anaplastic medulloblastoma metastatic to the scalp: tumor and derived stem-like cells features

Large cell anaplastic medulloblastoma metastatic to the scalp: tumor and derived stem-like cells features

Medulloblastoma with Subcutaneous Spread: A Rare Entity

Recommandations pour le don d’organes issus de patients porteurs de tumeurs primitives cérébrales ou médullaires de la part de l’Association des neuro-oncologues d’expression française (ANOCEF) et le Club de neuro-oncologie de la Société française de neurochirurgie

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