Medium-chain triglyceride reinforce the hepatic damage caused by fructose intake in mice

Guimarães, Janaina Azevedo; Bargut, Thereza Cristina Lonzetti; Mandarim-de-Lacerda, Carlos Alberto; Águila, Márcia Barbosa

doi:10.1016/j.plefa.2018.11.005

Cited by 19 publications

(11 citation statements)

References 53 publications

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“…One study found that consuming a diet containing MCTs suppressed hepatic lipid accumulation and lowered insulin resistance indices in male C57BL/6 mice fed a 48% fat energy diet for 16 weeks . However, another study reported that consuming a diet containing MCTs impaired hepatic function, with exacerbation of lipid accumulation in the hepatocytes caused by fructose intake, in C57BL/6 male mice fed the diet for 12 weeks . Taken together with the evidence from our study, although we did not verify fatty liver in the rats fed the LCT diet histologically, these data suggest that consuming MCTs with tomato powder may reduce the risk of fatty liver and liver injuries caused by LCT intake.…”

Section: Discussioncontrasting

confidence: 70%

“…30 However, another study reported that consuming a diet containing MCTs impaired hepatic function, with exacerbation of lipid accumulation in the hepatocytes caused by fructose intake, in C57BL/6 male mice fed the diet for 12 weeks. 31 Taken together with the evidence from our study, although we did not verify fatty liver in the rats fed the LCT diet histologically, these data suggest that consuming MCTs with tomato powder may reduce the risk of fatty liver and liver injuries caused by LCT intake. However, FASN and ACAC protein expression levels in rats fed the MCT diet for 2 weeks were not reduced by supplementation with tomato powder, although Acac and Scad1 mRNA expression were reduced by supplementation with tomato powder.…”

Section: Discussioncontrasting

confidence: 70%

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Feeding Rats Medium-Chain Triglycerides and Tomato Powder Increases Liver Lycopene Content and Reduces the Expression of Genes Related to Lipid Metabolism in the Liver

Kimura

Tamura

Ishiyama

et al. 2021

ACS Food Sci. Technol.

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Lycopene quenches reactive oxygen species effectively; however, its bioavailability is low owing to its high lipid solubility. Here, we assessed whether feeding Sprague−Dawley rats medium-chain triglycerides (MCTs), which promote the emulsification of lipid-soluble food components and are metabolized more rapidly than long-chain triglycerides (LCTs), along with tomato powder (T) affects lycopene accumulation and metabolism in the liver. Liver lycopene contents were higher in MCT+T-fed rats than in LCT+T-fed rats. Serum levels of high molecular weight adiponectin were markedly higher in MCT+T-fed rats than in the other groups. MCT+T-fed rats exhibited lower liver triglycerides compared with LCT+T-fed rats. Furthermore, the elevated Acaca and Scd1 mRNA expression levels observed in rats fed MCTs were decreased in rats fed MCT+T. These results suggest that feeding rats MCTs and T increased the liver lycopene content and systemic insulin sensitivity, improving lipid metabolism in the liver.

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Section: Discussioncontrasting

confidence: 70%

Section: Discussioncontrasting

confidence: 70%

Feeding Rats Medium-Chain Triglycerides and Tomato Powder Increases Liver Lycopene Content and Reduces the Expression of Genes Related to Lipid Metabolism in the Liver

Kimura

Tamura

Ishiyama

et al. 2021

ACS Food Sci. Technol.

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“…This information is consistent with results reported by Kelany et al (2017) [ 38 ] who noted a decrease in body weight after 8 weeks in the experimental phase with 200 mg/kg-day of curcumin; also, in an investigation carried out by Um et al (2013) [ 39 ], C57BL/6J mice were fed a high-fat diet for 11 weeks, obtaining a significant decrease in body weight in the group with curcumin at 0.15%, proving that the effect of body weight decrease does not only occur in the models induced with fructose, but also in those with a high-fat diet. However, no differences were found between the animals in the SC and NE-MCFA groups regarding weight and feed consumption as reported by Guimarães et al (2019) [ 40 ] in 3-month-old C57bl/6 mice after 12 weeks, when fructose and medium chain triglycerides were administered as treatment. Additionally, in the SC, NE-MCFA, and cNE-MCFA groups, feed consumption decreased significantly compared to the HC group and was comparable to the data reported by Mamikutty et al (2014) [ 41 ].…”

Section: Discussionmentioning

confidence: 53%

Effect of Curcumin Nanoemulsions Stabilized with MAG and DAG-MCFAs in a Fructose-Induced Hepatic Steatosis Rat Model

et al. 2021

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Current changes in diet, characterized by an increase in the intake of sweetened beverages, are heavily related to metabolic disorders such as non-alcoholic fatty liver. This condition can produce simple steatosis and, in worse cases, potentially result in steatohepatitis, fibrosis, and cirrhosis, comparable to the damage caused by the consumption of more or less 20–30 g of alcohol per day. The main objective of this research was to evaluate the effect of curcumin (Curcuma longa) nanoemulsions, using mono- and diacylglycerides medium chain fatty acids as stabilizers in an in vivo hepatic steatosis rat model. Pathology was induced by providing 30% fructose intake in the drinking water. Globule sizes under 200 nm that were stable for 4 weeks were obtained; curcumin encapsulated in the nanoemulsion was >70%. The results revealed an improvement regarding body and liver weight in the animals treated with curcumin nanoemulsions. A decrease in total cholesterol, LDL, AST/ALT, and HDL in serum was observed; however, no apparent improvement regarding serum glucose or triacylglycerides values was noted. Histological analysis showed a significant decrease in the extent of steatosis, inflammation, and brown adipose tissue in the treated animals.

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“…35 Despite the high-fat content, the HFF diet was able to reverse steatosis and progression of NAFLD. Though the role of medium chain fatty acid (MCFA) and medium chain triglycerides (MCT) seems controversial as MCT has been shown to cause steatosis, 36 while other studies have shown they reduce steatosis and hepatic injury by upregulating fatty acid liver oxidation. 37,38 Although MCFAs are associated with decreasing the ratio of Firmicutes to Bacteroidetes leading to a reduction in steatosis, we did not observe such changes in the HFF mice.…”

Section: Discussionmentioning

confidence: 99%

Modifying macronutrients is superior to microbiome transplantation in treating nonalcoholic fatty liver disease

et al. 2020

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Nonalcoholic fatty liver disease (NAFLD) is the leading cause of chronic liver injury and liver transplantation in Western countries. The pathogenesis of NAFLD includes overnutritionassociated metabolic syndrome or the improper consumption of dietary macro-and micronutrients that either support or prevent disease development. This altered nutrient landscape has been linked to shifts within the gut microbiota which can exacerbate liver pathology and the progression of NAFLD. Treatment goals for NAFLD target lifestyle and dietary modifications that restrict calories and adjust macronutrient content. It is not well understood how different macronutrients alter the microbiota and whether the diet-educated microbiota contribute to the resolution of disease. We fed mice a diet high in fat, cholesterol and fructose for 6 weeks and then in two different arms of the study, intervened with either a diet high in saturated and polyunsaturated fats and fiber or low in fats and fiber. In a second set of experiments, we performed microbiota transplants using cecal contents from mice fed one of the intervention diets to assess whether the diet-educated microbiota could impact clinical outcomes in mice fed a NAFLD-inducing diet. Pathology, steatosis, ALT/AST levels, and liver cytokine levels were measured as primary outcomes. We found that despite different microbiota compositions, both of the intervention diets reversed the progression of NAFLD and dampened inflammation. In contrast, transplantation of cecal contents from the intervention diet-fed mice to mice receiving a NAFLD-inducing diet was unable to prevent disease progression, and, in some cases, worsened disease. These data underscore the importance of dietary modifications to treat NAFLD and caution against the use of microbiota transplantation in the absence of dietary and lifestyle modifications.

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Medium-chain triglyceride reinforce the hepatic damage caused by fructose intake in mice

Cited by 19 publications

References 53 publications

Feeding Rats Medium-Chain Triglycerides and Tomato Powder Increases Liver Lycopene Content and Reduces the Expression of Genes Related to Lipid Metabolism in the Liver

Feeding Rats Medium-Chain Triglycerides and Tomato Powder Increases Liver Lycopene Content and Reduces the Expression of Genes Related to Lipid Metabolism in the Liver

Effect of Curcumin Nanoemulsions Stabilized with MAG and DAG-MCFAs in a Fructose-Induced Hepatic Steatosis Rat Model

Modifying macronutrients is superior to microbiome transplantation in treating nonalcoholic fatty liver disease

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