Medium-chain triglyceride ameliorates insulin resistance and inflammation in high fat diet-induced obese mice

Geng, Shanshan; Zhu, Weiwei; Xie, Chunfeng; Li, Xiaoting; Wu, Jieshu; Liang, Zhaofeng; Xie, Wei; Zhu, Jianyun; Huang, Cong; Zhu, Mingming; Wu, Rui; Zhong, Caiyun

doi:10.1007/s00394-015-0907-0

Cited by 72 publications

(63 citation statements)

References 47 publications

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“…These observations are in agreement with previous reports (Geng et al, 2016;Huang et al, 2004). Interestingly, these effects were reversed or significantly improved by replacing up to 20% of lard in the diet with shrimp oil.…”

Section: Shrimp Oil Improved Serum Lipid Profilesupporting

confidence: 93%

Shrimp oil extracted from the shrimp processing waste reduces the development of insulin resistance and metabolic phenotypes in diet-induced obese rats

Nair

Gagnon

Pelletier

et al. 2017

Appl. Physiol. Nutr. Metab.

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Diet-induced obesity, insulin resistance, impaired glucose tolerance, chronic inflammation, and oxidative stress represent the main features of type 2 diabetes mellitus. The present study was conducted to examine the efficacy and mechanisms of shrimp oil on glucose homeostasis in obese rats. Male CD rats fed a high-fat diet (52 kcal% fat) and 20% fructose drinking water were divided into 4 groups and treated with the dietary replacement of 0%, 10%, 15%, or 20% of lard with shrimp oil for 10 weeks. Age-matched rats fed a low-fat diet (10 kcal% fat) were used as the normal control. Rats on the high-fat diet showed impaired (p < 0.05) glucose tolerance and insulin resistance compared with rats fed the low-fat diet. Shrimp oil improved (p < 0.05) oral glucose tolerance, insulin response, and homeostatic model assessment-estimated insulin resistance index; decreased serum insulin, leptin, hemoglobin A1c, and free fatty acids; and increased adiponectin. Shrimp oil also increased (p < 0.05) antioxidant capacity and reduced oxidative stress and chronic inflammation. The results demonstrated that shrimp oil dose-dependently improved glycemic control in obese rats through multiple mechanisms.

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Section: Shrimp Oil Improved Serum Lipid Profilesupporting

confidence: 93%

Shrimp oil extracted from the shrimp processing waste reduces the development of insulin resistance and metabolic phenotypes in diet-induced obese rats

Nair

Gagnon

Pelletier

et al. 2017

Appl. Physiol. Nutr. Metab.

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“…Finally, as their levels are regulated by clocks, changing concentrations of MCTs could act as signaling molecules and modulate activities of kinases or nuclear transcription factors. Support for this hypothesis comes from a recent study showing that MCT feeding ameliorates insulin resistance and inflammation in high fat diet-induced obese mice (Geng et al, 2015). In conclusion, our results strongly support a key role of clock regulated metabolic adaptation under DR and pave the way for future longevity studies involving manipulations of clocks via environmental or pharmacological interventions.…”

Section: Discussionmentioning

confidence: 98%

Peripheral Circadian Clocks Mediate Dietary Restriction-Dependent Changes in Lifespan and Fat Metabolism in Drosophila

et al. 2016

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Endogenous circadian clocks orchestrate several metabolic and signaling pathways that are known to modulate lifespan, suggesting clocks as potential targets for manipulation of metabolism and lifespan. We report here that the core circadian clock genes, timeless (tim) and period (per), are required for the metabolic and lifespan responses to DR in Drosophila. Consistent with the involvement of a circadian mechanism, DR enhances the amplitude of cycling of most circadian clock genes, including tim, in peripheral tissues. Mass spectrometry-based lipidomic analysis suggests a role of tim in cycling of specific medium chain triglycerides under DR. Furthermore, overexpression of tim in peripheral tissues improves its oscillatory amplitude and extends lifespan under ad libitum conditions. Importantly, effects of tim on lifespan appear to be mediated through enhanced fat turnover. These findings identify a critical role for specific clock genes in modulating the effects of nutrient manipulation on fat metabolism and aging.

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“…Dietary supplementation of MCTs has been shown to prevent diet-induced liver pathologies and insulin resistance and is used in the treatment of refractory childhood epilepsy [106–108]. Interestingly, DR treatment has been shown to reduce seizures in rodent epilepsy models [109, 110]; however, whether MCTs are involved in the beneficial effects of DR is currently unknown and could be explored in future studies.…”

Section: Discussionmentioning

confidence: 99%

Dietary restriction protects from age-associated DNA methylation and induces epigenetic reprogramming of lipid metabolism

et al. 2017

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BackgroundDietary restriction (DR), a reduction in food intake without malnutrition, increases most aspects of health during aging and extends lifespan in diverse species, including rodents. However, the mechanisms by which DR interacts with the aging process to improve health in old age are poorly understood. DNA methylation could play an important role in mediating the effects of DR because it is sensitive to the effects of nutrition and can affect gene expression memory over time.ResultsHere, we profile genome-wide changes in DNA methylation, gene expression and lipidomics in response to DR and aging in female mouse liver. DR is generally strongly protective against age-related changes in DNA methylation. During aging with DR, DNA methylation becomes targeted to gene bodies and is associated with reduced gene expression, particularly of genes involved in lipid metabolism. The lipid profile of the livers of DR mice is correspondingly shifted towards lowered triglyceride content and shorter chain length of triglyceride-associated fatty acids, and these effects become more pronounced with age.ConclusionsOur results indicate that DR remodels genome-wide patterns of DNA methylation so that age-related changes are profoundly delayed, while changes at loci involved in lipid metabolism affect gene expression and the resulting lipid profile.Electronic supplementary materialThe online version of this article (doi:10.1186/s13059-017-1187-1) contains supplementary material, which is available to authorized users.

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Medium-chain triglyceride ameliorates insulin resistance and inflammation in high fat diet-induced obese mice

Cited by 72 publications

References 47 publications

Shrimp oil extracted from the shrimp processing waste reduces the development of insulin resistance and metabolic phenotypes in diet-induced obese rats

Shrimp oil extracted from the shrimp processing waste reduces the development of insulin resistance and metabolic phenotypes in diet-induced obese rats

Peripheral Circadian Clocks Mediate Dietary Restriction-Dependent Changes in Lifespan and Fat Metabolism in Drosophila

Dietary restriction protects from age-associated DNA methylation and induces epigenetic reprogramming of lipid metabolism

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