Shrimp oil extracted from the shrimp processing waste reduces the development of insulin resistance and metabolic phenotypes in diet-induced obese rats

Nair, Sandhya; Gagnon, Jacques; Pelletier, Claude; Tchoukanova, Nadia; Zhang, Junzeng; Ewart, H. Stephen; Ewart, K. Vanya; Jiao, Guangling; Wang, Yanwen

doi:10.1139/apnm-2016-0644

Cited by 17 publications

(18 citation statements)

References 65 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Similar results were reported for other marine protein sources such as cod–scallop, which reduced weight gain and serum glucose when used as the dietary protein source in mice fed a high-fat diet [25]. An increase in semi-fasting and fasting blood glucose levels is indicative of insulin resistance, which is commonly assessed by performing glucose tolerance testing and measuring a number of biomarkers in blood samples [18,19]. Mice in the HFC group showed significantly higher blood glucose levels at every time point of the two OGTTs conducted when compared to mice in the LFC group, demonstrating impaired glucose tolerance, in agreement with the results of many previous studies [19,26,27].…”

Section: Discussionsupporting

confidence: 67%

“…In a diet-induced obese mouse model, overnight fasting every week or two weeks ruins the model and makes the blood glucose level return to normal (unpublished data in another study). Therefore, semi-fasting blood glucose is commonly used to monitor the change in blood glucose levels during the course of treatment, and fasting blood glucose is measured at the end of the study [18,19]. In agreement with the observed weight changes, mice in the HFC group showed significantly higher semi-fasting blood glucose during the entire 10-week study period.…”

Section: Discussionmentioning

confidence: 85%

“…Chronic consumption of a high-fat diet induces obesity, hyperinsulinemia, hyperglycemia, and insulin resistance in C57BL/6J mice [18]. Increased weight gain and induction of insulin resistance by a high-fat diet were also observed in other rodent species [19]. In the present study, mice on the high-fat diet consumed less food but higher energy as compared to the low-fat controls, resulting in a significant increase in weight gain and body weight, in accordance with many previous studies [18,20].…”

Section: Discussionmentioning

confidence: 99%

“…An increase in semi-fasting and fasting blood glucose levels is indicative of insulin resistance, which is commonly assessed by performing glucose tolerance testing and measuring a number of biomarkers in blood samples [18,19]. Mice in the HFC group showed significantly higher blood glucose levels at every time point of the two OGTTs conducted when compared to mice in the LFC group, demonstrating impaired glucose tolerance, in agreement with the results of many previous studies [19,26,27]. Mice fed HPH displayed consistent reductions in blood glucose level at each time point during each OGTT when compared to mice fed the high-fat diet, and a significantly lower AUC was seen in mice of the HPH70 group.…”

Section: Discussionmentioning

confidence: 99%

“…In the present study, blood adiponectin and free fatty acid levels in mice were not affected by HPH supplementation, while body weight and most metabolic variables were significantly improved. Previous studies have shown mixed results regarding the association between blood adiponectin levels and body weight and other metabolic phenotypes [18,19,32]. In a study, dietary supplementation of taurine, a high-content component in fish protein, improved insulin resistance and dyslipidemia and reduced leptin levels but had no effect on adiponectin levels [32].…”

Section: Discussionmentioning

confidence: 99%

See 4 more Smart Citations

Herring Milt Protein Hydrolysate Improves Insulin Resistance in High-Fat-Diet-Induced Obese Male C57BL/6J Mice

et al. 2019

Self Cite

View full text Add to dashboard Cite

Protein consumption influences glucose homeostasis, but the effect depends on the type and origin of proteins ingested. The present study was designed to determine the effect of herring milt protein hydrolysate (HPH) on insulin function and glucose metabolism in a mouse model of diet-induced obesity. Male C57BL/6J mice were pretreated with a low-fat diet or a high-fat diet for 6 weeks. Mice on the high-fat diet were divided into four groups where one group continued on the high-fat diet and the other three groups were fed a modified high-fat diet where 15%, 35%, and 70%, respectively, of casein was replaced with an equal percentage of protein derived from HPH. After 10 weeks, mice that continued on the high-fat diet showed significant increases in body weight, blood glucose, insulin, and leptin levels and exhibited impaired oral glucose tolerance, insulin resistance, and pancreatic β-cell dysfunction. Compared to mice fed the high-fat diet, the 70% replacement of dietary casein with HPH protein reduced body weight, semi-fasting blood glucose, fasting blood glucose, insulin, leptin, and cholesterol levels and improved glucose tolerance, homeostasis model assessment of insulin resistance (HOMA-IR), and homeostasis model assessment of β-cell function (HOMA-β) indices. The 35% replacement of dietary casein with HPH protein showed moderate effects, while the 15% replacement of dietary casein with HPH protein had no effects. This is the first study demonstrating that replacing dietary casein with the same amount of protein derived from HPH can prevent high-fat-diet-induced obesity and insulin resistance.

show abstract

Section: Discussionsupporting

confidence: 67%

Section: Discussionmentioning

confidence: 85%

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

See 3 more Smart Citations

Herring Milt Protein Hydrolysate Improves Insulin Resistance in High-Fat-Diet-Induced Obese Male C57BL/6J Mice

et al. 2019

Self Cite

View full text Add to dashboard Cite

show abstract

Anti-inflammatory Components from Functional Foods for Obesity

Panchal

Brown

2020

Pathophysiology of Obesity-Induced Health Complications

View full text Add to dashboard Cite

Obesity defined as excessive fat accumulation that may impair health has been described throughout human history, but it has now reached epidemic proportions with the WHO estimating that 39% of the world's adults over 18 years of age were overweight or obese in 2016. Obesity is a chronic low-grade inflammatory state leading to organ damage with an increased risk of common diseases including cardiovascular and metabolic disease, nonalcoholic fatty liver disease, osteoarthritis and some cancers. This inflammatory state may be influenced by adipose tissue hypoxia and changes in the gut microbiome. There has been an increasing focus on functional foods and nutraceuticals as treatment options for obesity as drug treatments are limited in efficacy. This chapter summarises the importance of anthocyanincontaining fruits and vegetables, coffee and its components, tropical fruit and food waste as sources of phytochemicals for obesity treatment. We emphasise that preclinical studies can form the basis for clinical trials to determine the effectiveness of these treatments in humans.

show abstract