Medipix 2 in X-ray diffraction

Vries, R.I. de; Weijers, S.; Bethke, Klaus; Kogan, V.; Vasterink, J. H. A.; Kharchenko, A.; Fransen, M.; Bethke, J.

doi:10.1016/j.nima.2007.01.175

Cited by 17 publications

(8 citation statements)

References 4 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…With the exception of very small specimens, the calculi were retained and representative samples were analysed by x‐ray diffraction analysis using a X'Pert PRO Multi‐Purpose Diffractometer (PANalytical) with copper Kα radiation. A PIXcel detector (PANalytical) was used to collect data (de Vries and others 2007).…”

Section: Methodsmentioning

confidence: 99%

Renal calculi in wild Eurasian otters (Lutra lutra) in England

Simpson

Tomlinson²,

Molenaar³

et al. 2011

Veterinary Record

View full text Add to dashboard Cite

Macroscopic renal calculi were seen in 50 of 492 (10.2 per cent) wild Eurasian otters found dead in England from 1988 to 2007. Forty-eight adults and two subadults were affected. Calculi were present in 15.7 per cent (31 of 197) of adult males and 12.7 per cent (17 of 134) of adult females. There was an increase in prevalence in the study population over time; no calculi were found in 73 otters examined between 1988 and 1996, but in most subsequent years they were observed with increased frequency. Calculi occurred in both kidneys but were more common in the right kidney. They varied greatly in shape and size; larger calculi were mostly seen in the calyces while the smallest ones were commonly found in the renal medulla. Calculi from 45 cases were examined by x-ray diffraction analysis; in 43 (96 per cent), they were composed solely of ammonium acid urate. Affected otters had heavier adrenal glands relative to their body size than unaffected otters (P<0.001). There was no significant association between body condition index and the presence of calculi (P>0.05). Many otters had fresh bite wounds consistent with intraspecific aggression. The proportion bitten increased over time and this coincided with the increased prevalence of renal calculi.

show abstract

Section: Methodsmentioning

confidence: 99%

Renal calculi in wild Eurasian otters (Lutra lutra) in England

Simpson

Tomlinson²,

Molenaar³

et al. 2011

Veterinary Record

View full text Add to dashboard Cite

show abstract

“…The only detectors presently able to offer the required angular resolution over a large range are segmented semiconductor detectors. Two-dimensional detectors are sometimes used for textured samples or stress-strain measurement (Basolo et al, 2007), but the existing systems are either limited in pixel size (Kraft et al, 2009) or in active area (de Vries et al, 2007).…”

Section: Synchrotron Radiation Detectors For Powder Diffractionmentioning

confidence: 99%

The MYTHEN detector for X-ray powder diffraction experiments at the Swiss Light Source

et al. 2010

View full text Add to dashboard Cite

The MYTHEN single-photon-counting silicon microstrip detector has been developed at the Swiss Light Source for time-resolved powder diffraction experiments. An upgraded version of the detector has been installed at the SLS powder diffraction station allowing the acquisition of diffraction patterns over 120 in 2 in fractions of seconds. Thanks to the outstanding performance of the detector and to the calibration procedures developed, the quality of the data obtained is now comparable with that of traditional high-resolution point detectors in terms of FWHM resolution and peak profile shape, with the additional advantage of fast and simultaneous acquisition of the full diffraction pattern. MYTHEN is therefore optimal for time-resolved or dose-critical measurements. The characteristics of the MYTHEN detector together with the calibration procedures implemented for the optimization of the data are described in detail. The refinements of two known standard powders are discussed together with a remarkable application of MYTHEN to organic compounds in relation to the problem of radiation damage.

show abstract

“…However, many of the applications with the highest dynamic ranges use (quasi-)monochromatic radiation, e.g., protein crystallography [4], X-ray reflectometry [5], Xray computed tomography [8], X-ray imaging [40], and wavelength dispersive spectrometry [41]; this simplifies considerably the task of estimating the effect of photon pile-up on the counters and linearizing the pixel response.…”

Section: Photon Pile-upmentioning

confidence: 99%

“…This enabled almost two decades ago the first highly segmented photon counting pixel detectors, with 64 K photon counting pixels per ASIC [3]. Entire research fields would be unrecognizable without the current wide availability of photon counting detectors: protein crystallography [4], industrial X-ray diffraction [5], electron microscopy [6], medical imaging [7], computed tomography [8].…”

Section: Introductionmentioning

confidence: 99%

Dead-time correction for spectroscopic photon-counting pixel detectors

Blaj¹

2019

J Synchrotron Rad

View full text Add to dashboard Cite

Modern photon‐counting pixel detectors have enabled a revolution in applications at synchrotron light sources and beyond in the last decade. One of the limitations of the current detectors is their reduced counting linearity or even paralysis at high counting rates, due to dead‐time which results in photon pile‐up. Existing dead‐time and pile‐up models fail to reproduce the complexity of dead‐time effects on photon‐counting, resulting in empirical calibrations for particular detectors at best, imprecise linearization methods, or no linearization. This problem will increase in the future as many synchrotron light sources plan significant brilliance upgrades and free‐electron lasers plan moving to a quasi‐continuous operation mode. Presented here are the first models that use the actual behavior of the analog pre‐amplifiers in spectroscopic photon‐counting pixel detectors with constant current discharge (e.g. the Medipix and CPix families of detectors) to deduce more accurate analytical models and optimal linearization methods. In particular, for detectors with at least two counters per pixel, the need for calibration, or previous knowledge of the detector and beam parameters (dead‐time, integration time, large sets of synchrotron filling patterns), is completely eliminated. This is summarized in several models of increasing complexity and accuracy. Finally, a general empirical approach is presented, applicable to any particular cases where the analytical approach is not sufficiently precise.

show abstract

Medipix 2 in X-ray diffraction

Cited by 17 publications

References 4 publications

Renal calculi in wild Eurasian otters (Lutra lutra) in England

Renal calculi in wild Eurasian otters (Lutra lutra) in England

The MYTHEN detector for X-ray powder diffraction experiments at the Swiss Light Source

Dead-time correction for spectroscopic photon-counting pixel detectors

Contact Info

Product

Resources

About