Medicinal uses of plants by Indian tribes of Nevada. Part III, (pages 130-199)

Train, Percy.; Archer, W. Andrew; Henrichs, James R.

doi:10.5962/bhl.title.80439

Cited by 7 publications

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“…In addition, Salvia sp. was traditionally used to treat paralysis and as a sedative and analgesic medicine (Bocek, 1984; Train, 1941; Zigmond, 1981). A species related to Trifolium pratense, Trifolium repens , was previously reported to treat paralysis (Herrick, 1977) (Supplementary Table 3).…”

Section: Resultsmentioning

confidence: 99%

Pikuni-Blackfeet traditional medicine: Neuroprotective activities of medicinal plants used to treat Parkinson’s disease-related symptoms

Jacquet

Tambe

Ying

et al. 2017

Journal of Ethnopharmacology

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Ethnopharmacological relevance Parkinson’s disease (PD) is a multifactorial neurodegenerative disorder affecting 5% of the population over the age of 85 years. Current treatments primarily involve dopamine replacement therapy, which leads to temporary relief of motor symptoms but fails to slow the underlying neurodegeneration. Thus, there is a need for safe PD therapies with neuroprotective activity. In this study, we analyzed contemporary herbal medicinal practices used by members of the Pikuni-Blackfeet tribe from Western Montana to treat PD-related symptoms, in an effort to identify medicinal plants that are affordable to traditional communities and accessible to larger populations. Aim of the study The aims of this study were to (i) identify medicinal plants used by the Pikuni-Blackfeet tribe to treat individuals with symptoms related to PD or other CNS disorders, and (ii) characterize a subset of the identified plants in terms of antioxidant and neuroprotective activities in cellular models of PD. Materials and Methods Interviews of healers and local people were carried out on the Blackfeet Indian reservation. Plant samples were collected, and water extracts were produced for subsequent analysis. A subset of botanical extracts was tested for the ability to induce activation of the Nrf2-mediated transcriptional response and to protect against neurotoxicity elicited by the PD-related toxins rotenone and paraquat. Results The ethnopharmacological interviews resulted in the documentation of 19 medicinal plants used to treat various ailments and diseases, including symptoms related to PD. Seven botanical extracts (out of a total of 10 extracts tested) showed activation of Nrf2-mediated transcriptional activity in primary cortical astrocytes. Extracts prepared from Allium sativum cloves, Trifolium pratense flowers, and Amelanchier arborea berries exhibited neuroprotective activity against toxicity elicited by rotenone, whereas only the extracts prepared from Allium sativum and Amelanchier arborea alleviated PQ-induced dopaminergic cell death. Conclusions Our findings highlight the potential clinical utility of plants used for medicinal purposes over generations by the Pikuni-Blackfeet people, and they shed light on mechanisms by which the plant extracts could slow neurodegeneration in PD.

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Section: Resultsmentioning

confidence: 99%

Pikuni-Blackfeet traditional medicine: Neuroprotective activities of medicinal plants used to treat Parkinson’s disease-related symptoms

Jacquet

Tambe

Ying

et al. 2017

Journal of Ethnopharmacology

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“…P. polydenius has thus been described as "the medicinal cure-all of the desert tribes". 3,4 Previous investigation of P. polydenius resulted in the isolation of the red dye dalrubone and demethoxymatteucinol. 5 However, there is no previous report of any antiprotozoal activity associated with this plant.…”

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Antiprotozoal Compounds from Psorothamnus polydenius

Salem

Werbovetz

2004

J. Nat. Prod.

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Bioactivity-guided fractionation of the methanolic extract of Psorothamnus polydenius yielded the new chalcone 2,2',4'-trihydroxy-6'-methoxy-3',5'-dimethylchalcone (2), together with six other known compounds, 2',4'-dihydroxy-6'-methoxy-3',5'-dimethylchalcone (1), dalrubone (3), demethoxymatteucinol (4), eriodictyol (5), and photodalrubone (6a and 6b). This is the first report of chalcones in P. polydenius. The extracts and isolated compounds were tested in vitro for their antiprotozoal activity against Leishmania donovani and Trypanosoma brucei. Chalcones 1 and 2 and dalrubone (3) exhibited leishmanicidal (IC(50) 5.0, 7.5, and 7.5 microg/mL, respectively) and trypanocidal (IC(50) 6.3, 6.8, and 21.6 microg/mL, respectively) properties. Dalrubone (3) displayed 6-fold selectivity for axenic L. donovani parasites over Vero cells. Furthermore, treatment of L. mexicana-preinfected macrophages with chalcones 1 and 2 and dalrubone (3) (12.5, 12.5, and 25 microg/mL, respectively) reduced the number of infected macrophages by at least 96% while posing no toxicity to the host cell.

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“…Several species have had use in the past to treat colds, tuberculoses, bladder problems, skin cuts, and other ailments (2,3). Whole plant extracts of eight species were screened for lP toxicity in mice, with one species (E. brevicaule Nutt.)…”

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Cytotoxic Phenolic Glucosides from Flowers ofEriogonum brevicaule

Abdel‐Kader¹,

Stermitz²

1996

Planta Med

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The genus Eriogonum, wild buckwheat (Polygonaceae), comprises 150 species, mostly native to the West U. S. (1). Several species have had use in the past to treat colds, tuberculoses, bladder problems, skin cuts, and other ailments (2, 3). Whole plant extracts of eight species were screened for lP toxicity in mice, with one species (E. brevicaule Nutt.) exhibiting some lethality at 12.5mg/kg (4). The extract was also cytotoxic in the National Cancer Institute KB cell test at 18 pg/mI and showed marginal activity (TIC 118 and 132 in two tests) against P388 murine leukemia in mice (4). Antimicrobial activity of an extract of the native American medicinal plant F. umbellatum was traced to methyl gallate (5). Two alkaloids, hordenine and N-methyl-4-methoxyphenethylamine, were found in four Enogonum species, including F. brevicaule (6), while four gossypetin 7-methyl ether glycosides were found in E. nuduni (7).were collected on August 10, 1993 20km N. of Fort Collins, Colorado (Larimer Co.) and a voucher (FRS 479) deposited in the Colorado State University Herbarium.Extracts of leaves and flowers were quantitatively tested for cytotoxicity using the brine shrimp lethality (BSL) bioassay (8). For the assay, extracts and residues of chromatographic fractions were tested using two concentrations, 5 mg and 0.5 mg per vial, and each repeated twice. Colchicine was used as positive standard showing 100% mortality at 100ug/ml (ED50 = 15 ppm). Percent mortality was recorded after 24 h.Dried flowers (63.5g) and leaves (48.7g) were extracted separately with hexane/EtOAc (3 :2) and then MeOH. The MeOH extract of the flowers (8.5 g of residue) showed the strongest activity (100, 0.0% mortality at 5 and 0.5 mg/vial, respectively). The MeOH extract residue was fractionated (VLC, silica gel, 150g, CHCI3-MeOH mixtures). The fraction eluting with pure methanol (4.4 g) had the strongest activity (100, 10 % mortality). This material was fractionated (VLC, C18silica gel, 150g. H20-MeOH mixtures) with the most active fraction (1.7g; 100, 80% mortality) eluting with 40% MeOH. This residue was subjected to preparative TLC (silica gel, EtOAc/MeOH/H20 30:5:4) to yield 28mg of 1-/3-o-glucopyranosyloxy-3,5-dihydroxybenzene (R =0.48) (9) and 52mg of 1 -13-D-glucopyranosyloxy-3-methoxy-5-hydroxybenzene (R = 0.61) (10). These were identified by comparison of their 1H-and 13C-NMR spectra with those in the literature (9, 10). Copies of the original spectra are obtainable from the author of correspondence. Final lethalities were at 150 ppm for the isolated 3-methoxy-5-hydroxybenzene derivative and 1103 ppm for the 3,5-dihydroxybenzene derivative.This and previous studies (5, 6) suggest that further work on the possible medicinal potential of Eriogonum species is warranted.

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Medicinal uses of plants by Indian tribes of Nevada. Part III, (pages 130-199)

Cited by 7 publications

References 0 publications

Pikuni-Blackfeet traditional medicine: Neuroprotective activities of medicinal plants used to treat Parkinson’s disease-related symptoms

Pikuni-Blackfeet traditional medicine: Neuroprotective activities of medicinal plants used to treat Parkinson’s disease-related symptoms

Antiprotozoal Compounds from Psorothamnus polydenius

Cytotoxic Phenolic Glucosides from Flowers ofEriogonum brevicaule

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