Medicinal Property of Gotu kola (Centella asiatica) from the Selection of Traditional Applications to the Novel Phytotherapy

Hamidpour, Rafie

doi:10.21767/2254-6081.100042

Cited by 6 publications

(5 citation statements)

References 15 publications

(45 reference statements)

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“…Animal studies have revealed that C. asiatica improves memory, increases response time, and aids in wound healing. C. asiatica aqueous extract in dose-dependent amounts decreased the appearance of aging skin, collagen, and topical scars[ 81 ]. In vivo and in vitro studies of the methanolic fraction of C. asiatica exhibited great polyvalent activity, indicating that it has the potential to be an efficient wound healer[ 82 ].…”

Section: Discussionmentioning

confidence: 99%

Acknowledging the use of botanicals to treat diabetic foot ulcer during the 21^st century: A systematic review

Narzary¹,

Swarnakar²,

Kalita³

et al. 2023

World J Clin Cases

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BACKGROUND Diabetic foot ulcer (DFU) is a serious health issue of diabetes mellitus that affects innumerable people worldwide. Management and treatment of this complication are challenging, especially for those whose immune system is weak. AIM To discuss the plants and their parts used to heal DFU, along with the mode of their administration in diabetic patients. METHODS The original articles on “the plants for the treatment of DFU” studied in clinical cases only were obtained from various bibliographic databases using different keywords. RESULTS The search resulted in 22 clinical cases records with 20 medicinal plants belonging to 17 families on 1553 subjects. The fruits and leaves were the most preferentially used parts for DFU treatment, regardless of whether they were being administered orally or applied topically. Of the 20 medicinal plants, 19 reported their effectiveness in increasing angiogenesis, epithelialization, and granulation, thus hastening the wound-healing process. The efficacy of these botanicals might be attributed to their major bioactive compounds, such as actinidin and ascorbic acid (in Actinidia deliciosa ), 7-O-(β-D-glucopyranosyl)-galactin (in Ageratina pichinchensis ), omega-3-fatty acid (in Linum usitatissimum ), isoquercetin (in Melilotus officinalis ), anthocyanins (in Myrtus communis ), and plantamajoside (in Plantago major ). CONCLUSION The validation of mechanisms of action underlying these phytocompounds contributing to the management of DFU can aid in our better understanding of creating efficient treatment options for DFU and its associated problems.

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Section: Discussionmentioning

confidence: 99%

Acknowledging the use of botanicals to treat diabetic foot ulcer during the 21^st century: A systematic review

Narzary¹,

Swarnakar²,

Kalita³

et al. 2023

World J Clin Cases

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“…It has also reversed aging induced amnesia due to natural aging of mice suggesting that the compound in this plant may prove to be useful in restoring memory in older individuals as well as in patients with age-associated dementia 11. Centella asiatica: [40][41][42][43][44][45][46][47][48] It Water extract of this plant has shown mitigation of Aβinduced cell death and also it has attenuated Aβ-induced alternations in Tau expression and phosphorylation in cell lines (according to Gray nora. et.al,).…”

Section: Nardostachys Jatamanasi (Jatamansi): 10mentioning

confidence: 99%

An updated review on Anti-Alzheimer’s herbal drugs

Sanka¹,

Santhipriya²,

Nadendla³

2018

J. Drug Delivery Ther.

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Alzheimer’s disease (AD) is related to cognitive impairment, dementia observed generally in aged population due to neurodegeneration in an ongoing manner. It gradually worsens memory power of the patient. The hallmark diagnosis features includes formation of senile plaques and Neurofibrillary tangles (NFT’S) [1, 2]. Too little availability of Acetyl choline (ACh) a neurotransmitter in the cerebral region due to metabolism by an enzyme Acetyl choline esterase before showing its action and neural death are the primary reasons for AD. There are many categories of Anti-Alzheimer’s drugs available for management of AD in the market but due to lack of patient compliance successful outcomes were not observed [3]. Apart from this including Nutraceuticals in diet daily routine, Aromatherapy, modifications in the regular schedule, practicing yoga regularly relaxes mind and body from tensions, insomnia, blood circulation, detoxification of organs due to rhythmic breathings and reduce frequency of incidence of headache are proven to show best results by relieving stress according to survey[4-9]. At present herbal medicine has turn out to be best choice for the management of AD because of its availability, very economic, good patient compliance, ease of formulation and lower deleterious side effects [10, 11]. Novel techniques can be used for the development of herbal medicine. This review totally discuses about the occurrence of AD, its Pathophysiology, different stages in the disorder, various selective therapeutic targets for AD, available Anti-AD herbal drugs such as Curcumin, Withania somnifera, Bhrami, Ginkgo biloba, guggul, ginseng, herbs with essential oils, volatile oils, source and cultivation of the herbs, mechanism of action of the Phytochemicals in the herb responsible for treating AD. Keywords: Alzheimer’s disease (AD), cognitive impairment, Dementia, Senile plaques, Nutraceuticals, Herbal medicine, Phytoconstituents.

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“…While, Orhan [7] reported that Asiatic pennywort could be suggested to be a desired phytopharmaceutical with neuroprotective effect. According with, Hamidpour et al [8] were found that Asiatic pennywort enhanced memory and cognitive effect.…”

Section: Introductionmentioning

confidence: 99%

Variability of Morphological and Agronomical Characteristics of Centella asiatica in Thailand

et al. 2021

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The phenotypic variability of 30 accessions of Asiatic pennywort (Centella asiatica (L.) Urb.) were collected in different regions in Thailand were evaluated. The growth habit among accessions were identified into 2 types including with 20 accessions of erect from and 10 accessions of flatten from. The leaf arrangement divided into 2 types, including with rosette (20 accessions) and spreading leaf (10 accessions). The variability of morphological and agronomical characteristics experiment was derived by Complete Randomized Design (CRD) with 5 replications. The 11 morphological and agronomical character data were collected at 2 mounts after transplant. The phylogenetic tree manifesting the diversity among 30 accessions based on Euclidean distance coefficient identified by 11 morphological and agronomical characteristics. Analysis of variance revealed high and highly significant difference among accessions for all characteristics, shown a wide range of morphological and agronomical characteristics variability of the Asiatic pennywort germplasm. The phylogenetic tree was classified Asiatic pennywort accessions into 2 different clusters with the distance coefficient ranged from 1.00 - 25.00. The 1st cluster consisted of 8 accessions and the 2nd cluster consisted of 22 accessions. The 2nd cluster was divided into 2 sub- clusters, including with sub-cluster 2.1 consisted of 21 accessions and sub-cluster 2.2 consisted of 1 accession. Mean value of the 2nd cluster was higher than the 1st group all characters except SPAD Index. The result suggested that could be used accession members in the 2nd cluster can be used for future breeding program of Asiatic pennywort in Thailand. HIGHLIGHTS The morphology and actives ingredient components of Asiatic pennywort were depended on the genetic variability and geographical conditions The variability based on morphological and agronomic characteristics of Asiatic pennywort was useful for breeding perspective The Asiatic pennywort accessions in cluster 2 could be used for breeding program in the future GRAPHICAL ABSTRACT

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Medicinal Property of Gotu kola (Centella asiatica) from the Selection of Traditional Applications to the Novel Phytotherapy

Cited by 6 publications

References 15 publications

Acknowledging the use of botanicals to treat diabetic foot ulcer during the 21^st century: A systematic review

Acknowledging the use of botanicals to treat diabetic foot ulcer during the 21^st century: A systematic review

An updated review on Anti-Alzheimer’s herbal drugs

Variability of Morphological and Agronomical Characteristics of Centella asiatica in Thailand

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Medicinal Property of Gotu kola (Centella asiatica) from the Selection of Traditional Applications to the Novel Phytotherapy

Cited by 6 publications

References 15 publications

Acknowledging the use of botanicals to treat diabetic foot ulcer during the 21st century: A systematic review

Acknowledging the use of botanicals to treat diabetic foot ulcer during the 21st century: A systematic review

An updated review on Anti-Alzheimer’s herbal drugs

Variability of Morphological and Agronomical Characteristics of Centella asiatica in Thailand

Contact Info

Product

Resources

About

Acknowledging the use of botanicals to treat diabetic foot ulcer during the 21^st century: A systematic review

Acknowledging the use of botanicals to treat diabetic foot ulcer during the 21^st century: A systematic review