Medicinal plants with hepatoprotective activity in Iranian folk medicine

Asadi-Samani, Majid; Kafash-Farkhad, Najme; Azimi, N.; Fasihi, Ali; Alinia-Ahandani, Ebrahim; Rafieian-Kopaei, Mahmoud

doi:10.1016/s2221-1691(15)30159-3

Cited by 97 publications

(60 citation statements)

References 63 publications

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“…This active substance had been implicated as hepatic cells restorer and/or healer [42,43] . In addition, garlic has long been used medicinally, most recently for its cardiovascular, anti-neoplastic, and clinical antimicrobial activities [44,45] . Studies had also shown its significant lipid-lowering effects in the liver and anti-platelet activity [46,47] .…”

Section: Discussionmentioning

confidence: 99%

Research on garlic capsule and selenium-vitamin A, vitamin B, vitamin C applied in therapy of acute hepatocellular damage in a rat model

Akintunde

Bolarin

2015

Journal of Acute Disease

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A B S T R A C TObjectives: To evaluate the toxicity of lisinopril in liver of male rats and its reversal effect of garlic capsule (GAR) and selenium-vitamin A, vitamin B, vitamin C (SACE). Methods: Thirty five adult male wistar rats were randomly assigned into 5 groups of 7 animals per group. Group I serves as the control, animals in Groups II, III, IV and V received 28 mg/kg body weight of lisinopril via oral route. Group III was co-treated with GAR at therapeutic dose of 250 mg/kg body weight per day. Group IV was co-treated with SACE at dose of 500 mg/kg body weight. Lastly, group V was co-treated with GAR and SACE at doses of 250 and 500 mg/kg body weight respectively, and the experiment last for 8 days.Results: Administration of lisinopril caused systemic toxicity in liver as well as adverse histopathologic changes in the tested tissue. While GAR and SACE significantly (P < 0.05) reversed the toxic effects induced by lisinopril. Conclusions: Collectively, the results suggest that therapeutic dose of lisinopril elicits toxicity in male rats through induction of oxidative damage and depletion of cellular adenosine triphosphate. The reversal effects of GAR and SACE during lisinopril treatment suggest that these antioxidants may find clinical application in cellular damage involving ROS and adenosine triphosphate.

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Section: Discussionmentioning

confidence: 99%

Research on garlic capsule and selenium-vitamin A, vitamin B, vitamin C applied in therapy of acute hepatocellular damage in a rat model

Akintunde

Bolarin

2015

Journal of Acute Disease

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“…Therefore, hepatoprotective potentiality of PPE is generally evaluated against CCl 4 - induced liver damages in murine model [16, 17]. Several lead chemicals like silymarin, β-sitosterol, betalain, neoandrographolide, phyllanthin, andrographolide, curcumin, picroside, hypophyllanthin, kutkoside, and glycyrrhizin that have demonstrable hepatoprotective properties, were characterized from several PPEs [18]. High antioxidant activity in flower extracts of different plants such as Tecoma stans , Hibiscus sabdariffa , Calendula officinalis , and Crocus sativus , were screened for hepatoprotective activity by the previous research and proved viable.…”

Section: Introductionmentioning

confidence: 99%

Radical Scavenging Activities of Lagerstroemia speciosa (L.) Pers. Petal Extracts and its hepato-protection in CCl4-intoxicated mice

Tiwary

Dutta

Dey

et al. 2017

BMC Complement Altern Med

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Background Lagerstroemia speciosa (L.) Pers. has medicinal importance. Bioactive phytochemicals isolated from different parts of L. speciosa, have revealed hypoglycemic, antibacterial, anti-inflammatory, antioxidant and hepato protective properties. Despite one report from Philippines detailing the use of L. speciosa as curative for fever and as well as diuretic, there is no experimental evidence about the hepatoprotective activity of the flower extracts.MethodsSeveral spectroscopic methods, including GC–MS, were used to characterize phytochemicals present in the petal extract of L. speciosa. Ethanol extract of petals was evaluated for anti-oxidant and free radical scavenging properties by using methods related to hydrogen atom transfer, single electron transfer, reducing power, and metal chelation. This study has also revealed the in vitro antioxidant and in vivo hepatoprotective properties of petal extract against carbon tetra chloride (CCl4)-induced liver toxicity in Swiss albino mice. Hepatoprotection in CCl4 -intoxicated mice was studied with the aid of histology and different enzymatic and non-enzymatic markers of liver damage. Cytotoxicity tests were done using murein spleenocytes and cancareous cell lines, MCF7 and HepG2.ResultGCMS of the extract has revealed the presence of several potential antioxidant compounds, of them γ-Sitosterol and 1,2,3-Benzenetriol (Pyrogallol) were the predominant ones. The antioxidants activities of the flower-extract were significantly higher than curcumin (in terms of Nitric oxide scavenging activity; p = 0.0028) or ascorbic acid (in terms of 2,2-Diphenyl-1-Picrylhydrazyl (DPPH) assay; p = 0.0022). The damage control by the flower extract can be attributed to the reduction in lipid peroxidation and restoration of catalase activity. In vitro cytotoxicity tests have shown that the flower extract did not affect growth and survivability of the cell lines. It left beyond doubt that a flower of L. speciosa is a reservoir of antioxidant and hepatoprotective agents capable of reversing the damage inflicted by CCl4-intoxication.ConclusionResults from the present study may be used in developing a potential hepato-protective health drink enriched with antioxidants from Lagerstroemia speciosa (L.) Pers.Electronic supplementary materialThe online version of this article (doi:10.1186/s12906-016-1495-0) contains supplementary material, which is available to authorized users.

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“…Mojarrab et al 2014 [11] studied antioxidant activity and TPC of hydroethanolic extract of Tragopogon buphthalmoides from Iran. Asadi-Samani et al 2015 studied medicinal plants with hepatoprotective activity in Iranian folk medicine and including Tragopogon porrifolius [12]. …”

Section: Introductionmentioning

confidence: 99%

Anticancer Activity, Antioxidant Activity, and Phenolic and Flavonoids Content of WildTragopogon porrifoliusPlant Extracts

Al‐Rimawi

Rishmawi

Ariqat

et al. 2016

Evidence-Based Complementary and Alternative Medicine

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Tragopogon porrifolius, commonly referred to as white salsify, is an edible herb used in folk medicine to treat cancer. Samples of Tragopogon porrifolius plant grown wild in Palestine were extracted with different solvents: water, 80% ethanol, and 100% ethanol. The extracts were analyzed for their total phenolic content (TPC), total flavonoid content (TFC), and antioxidant activity (AA). Four different antioxidant assays were used to evaluate AA of the extracts: two measures the reducing power of the extracts (ferric reducing antioxidant power (FRAP) and cupric reducing antioxidant power (CUPRAC)), while two other assays measure the scavenging ability of the extracts (2,2-azino-di-(3-ethylbenzothialozine-sulphonic acid (ABTS)) and 2,2-diphenyl-1-picrylhydrazyl (DPPH)). Anticancer activity of the plant extracts were also tested on HOS and KHOS osteosarcoma cell lines. The results revealed that the polarity of the extraction solvent affects the TPC, TFC, and AA. It was found that both TPC and AA are highest for plant extracted with 80% ethanol, followed by water, and finally with 100% ethanol. TFC however was the highest in the following order: 80% ethanol > 100% ethanol > water. The plant extracts showed anticancer activities against KHOS cancer cell lines; they reduced total cell count and induced cell death in a drastic manner.

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Medicinal plants with hepatoprotective activity in Iranian folk medicine

Cited by 97 publications

References 63 publications

Research on garlic capsule and selenium-vitamin A, vitamin B, vitamin C applied in therapy of acute hepatocellular damage in a rat model

Research on garlic capsule and selenium-vitamin A, vitamin B, vitamin C applied in therapy of acute hepatocellular damage in a rat model

Radical Scavenging Activities of Lagerstroemia speciosa (L.) Pers. Petal Extracts and its hepato-protection in CCl4-intoxicated mice

Anticancer Activity, Antioxidant Activity, and Phenolic and Flavonoids Content of WildTragopogon porrifoliusPlant Extracts

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