Medicinal plants used in treatment and management of cancer in Kakamega County, Kenya

Ochwang’i, Dominic O.; Kimwele, Charles; Oduma, Jemimah A.; Gathumbi, P. K.; Mbaria, James Mucunu; Kiama, Stephen G.

doi:10.1016/j.jep.2013.11.051

Cited by 220 publications

(143 citation statements)

References 80 publications

Supporting

Mentioning

131

Contrasting

Unclassified

Order By: Relevance

“…In Kenya, it grows in the wild in the highland regions of the country, but has also been domesticated by several communities (Gachie et al, 2012). P. africana is used traditionally for the treatment of colorectal, breast and skin cancer (Ochwang'i et al, 2014). The bark and leaf extracts are also used to treat fevers, gonorrhoea and stomach pains (Stewart, 2003a).…”

Section: Introductionmentioning

confidence: 99%

Phytochemistry, Cytotoxicity and Apoptosis Studies of Β-Sitosterol-3-O-Glucoside and Β -Amyrin From Prunus Africana

Maiyo¹,

Moodley²,

Singh³

2016

Afr J Tradit Complement Altern Med

View full text Add to dashboard Cite

Background: Prunus africana is used traditionally in many countries for the treatment of cancer and benign prostate hyperplasia. Materials and methods: In this study, compounds from the leaves and bark of this plant were isolated and tested for their cytotoxicity and apoptosis induction in two human cancer cell lines (hepatocellular carcinoma (HepG2) and colorectal carcinoma (Caco-2)) and a non-cancer cell line (embryonic kidney (HEK293)). GC-MS profiling of the extract was also conducted. Results: Three compounds (β-sitosterol, β-amyrin and β-sitosterol-3-O-glucoside) were isolated and the cytotoxic activity of β-amyrin and β-sitosterol-3-O-glucoside on the HepG2, Caco-2 and HEK293 was determined using the MTT cell viability assay. Both compounds had significant cytotoxic activity towards the Caco-2 cell line with IC50 values of 81 μg mL -1 and 54 μg mL -1 for β-amyrin and β-sitosterol-3-O-glucoside, respectively while low cytotoxicity was observed on HepG2 cell lines with IC50 values of 206 μg mL -1 and 251 μg mL -1 for β-amyrin and β-sitosterol-3-O-glucoside, respectively. Apoptosis induction in cells was studied using acridine orange/ethidium bromide dual staining. In both cases, the compounds tested demonstrated selective cytotoxicity towards cancer cells with high apoptosis indices in cells exposed to β-amyrin. Low IC50 values of 156 μg mL -1 and 937 μg mL -1 for β-amyrin and β-sitosterol-3-O-glucoside, respectively, were observed in the HEK293 cell line. Conclusion: This study reveals that the plant is rich biologically active compounds thereby validating its ethno-medicinal use.

show abstract

Section: Introductionmentioning

confidence: 99%

Phytochemistry, Cytotoxicity and Apoptosis Studies of Β-Sitosterol-3-O-Glucoside and Β -Amyrin From Prunus Africana

Maiyo¹,

Moodley²,

Singh³

2016

Afr J Tradit Complement Altern Med

View full text Add to dashboard Cite

show abstract

“…Infusion of stem bark and roots orally taken in the treatment of cancer (Ochwang'I et al, 2014), prostate and urinary tract infections (Wambugu et al, 2011) bark decoction management of back pain in women and treatment of HIV/AIDs (Njoroge and Bussman, 2009). …”

Section: Dovyalis Abyssinica (Flacourtiaceae)mentioning

confidence: 99%

“…Safe, with slight renal toxicity up to high dose of 5000 mg/kg (Oloro et al, 2015) Used to treat malaria (Njoroge and Bussmann, 2006) , dried powder applied topically to treat skin cancer (Ochwang'I et al, 2014) leaf decoction taken orally to manage diabetes (Keter and Mutiso, 2012). Roots decoction is used as an aphrodisiac (Njoroge and Bussmann, 2009).…”

Section: Rothecamentioning

confidence: 99%

Medicinal plants used in the management of diabetes by traditional healers of Narok County, Kenya

Kamau¹,

Mbaabu²,

Karuri³

et al. 2017

TANG [HUMANITAS MEDICINE]

View full text Add to dashboard Cite

The Maasai community from Kenya is highly esteemed for their strong adherence to traditional cultures and ethno medicine. This is attributed to their age-old traditional mechanisms of passing down knowledge to the younger generation. Adoption to new socio-economic lifestyle and urbanization has been associated with development of diabetes, which has been reported among some indigenous pastoral communities in Kenya. Documentation of traditional methods of treatment and management of diabetes by the Maasai has not yet been reported, yet it is noteworthy. Thirty traditional healers from Narok County were purposively selected and interviewed about traditional knowledge of antidiabetic medicinal plants, parts used, preparation dosage and administration. A total of 14 antidiabetic plant species distributed within 13 genera and 12 families were identified and documented as herbal medicine used in the management of diabetes. The most highly cited plant species was Dovyalis abyssinica (20%), the plant family Flacourtiaceae and Rhamnaceae (2 plant species each) recorded the highest number of plant species while the most frequently used plant part was the roots (46%). Literature review revealed that some of the cited plants have known phytochemicals with antidiabetic activity; the study recommends further scientific investigation to validate their efficacy and safety.

show abstract

“…Despite the wide use of chemotherapy in breast cancer (BC) treatment but current methods such as chemotherapy have their limitations due to their toxic effects on non-targeted tissues causing human health problems (Ochwang'I et al, 2014). Therefore, the chemoprevention with natural phytochemical compounds is highly demanded for alternative treatments emerging strategies to enhance BC treatment.…”

Section: …………………………………………………………………………………………………… Introduction:-mentioning

confidence: 99%

Combination Effect of Zizyphus Spina Christi and Hyperthermia on Liver and Kidney Affected by Eac in Mice.

Okasha¹,

Takadom²,

Hassan³

2017

IJAR

View full text Add to dashboard Cite

Medicinal plants used in treatment and management of cancer in Kakamega County, Kenya

Cited by 220 publications

References 80 publications

Phytochemistry, Cytotoxicity and Apoptosis Studies of Β-Sitosterol-3-O-Glucoside and Β -Amyrin From Prunus Africana

Phytochemistry, Cytotoxicity and Apoptosis Studies of Β-Sitosterol-3-O-Glucoside and Β -Amyrin From Prunus Africana

Medicinal plants used in the management of diabetes by traditional healers of Narok County, Kenya

Combination Effect of Zizyphus Spina Christi and Hyperthermia on Liver and Kidney Affected by Eac in Mice.

Contact Info

Product

Resources

About