Medicinal plants used in the management of diabetes by traditional healers of Narok County, Kenya

Kamau, Loice Njeri; Mbaabu, Peter Mathiu; Karuri, Peter Gathumbi; Mbaria, James Mucunu; Kiama, Stephen G.

doi:10.5667/tang.2017.0008

Cited by 6 publications

(9 citation statements)

References 41 publications

(55 reference statements)

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“…Continued. Herb Infusion, decoction[11,17,34,43,44,46,58,78,88,89] Language is also known as Kikamba.Local names with language(s) not indicated are sometimes a blend of Kiswahili and other local languages or were not specified by the authors. Decoction involves boiling a plant part in water.…”

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confidence: 99%

Antimalarial Plants Used across Kenyan Communities

Omara

2020

Evidence-Based Complementary and Alternative Medicine

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Malaria is one of the serious health problems in Africa, Asia, and Latin America. Its treatment has been met with chronic failure due to pathogenic resistance to the currently available drugs. This review attempts to compile phytotherapeutical information on antimalarial plants in Kenya based on electronic data. A comprehensive web search was conducted in multidisciplinary databases, and a total of 286 plant species from 75 families, distributed among 192 genera, were retrieved. Globally, about 139 (48.6%) of the species have been investigated for antiplasmodial (18%) or antimalarial activities (97.1%) with promising results. However, there is no record on the antimalarial activity of about 51.4% of the species used although they could be potential sources of antimalarial remedies. Analysis of ethnomedicinal recipes indicated that mainly leaves (27.7%) and roots (19.4%) of shrubs (33.2%), trees (30.1%), and herbs (29.7%) are used for preparation of antimalarial decoctions (70.5%) and infusions (5.4%) in Kenya. The study highlighted a rich diversity of indigenous antimalarial plants with equally divergent herbal remedy preparation and use pattern. Further research is required to validate the therapeutic potential of antimalarial compounds from the unstudied claimed species. Although some species were investigated for their antimalarial efficacies, their toxicity and safety aspects need to be further investigated.

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confidence: 99%

Antimalarial Plants Used across Kenyan Communities

Omara

2020

Evidence-Based Complementary and Alternative Medicine

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“…An infusion from the leaves is used to treat bacterial diseases, ectoparasites, diabetes, fowl typhoid, nose bleeding, malaria, and wounds [40,41].…”

Section: Aloe Secundiflora Engl (Asphodelaceae)mentioning

confidence: 99%

Phytochemical Content and Antidiabetic Properties of Most Commonly Used Antidiabetic Medicinal Plants of Kenya

Muema,

Nanjala,

Oulo

et al. 2023

Molecules

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Traditional medicinal plants have been used for decades in folk medicines in the treatment and management of several ailments and diseases including diabetes, pain, ulcers, cancers, and wounds, among others. This study focused on the phytochemical and antidiabetic activity of the commonly used antidiabetic medicinal species in Kenya. Phytochemical profiling of these species revealed flavonoids and terpenoids as the major chemical classes reported which have been linked with strong biological activities against the aforementioned diseases, among others. However, out of the selected twenty-two species, many of the natural product isolation studies have focused on only a few species, as highlighted in the study. All of the examined crude extracts from thirteen antidiabetic species demonstrated strong antidiabetic activities by inhibiting α-glucosidase and α-amylase among other mechanisms, while nine are yet to be evaluated for their antidiabetic activities. Isolated compounds S-Methylcysteine sulfoxide, quercetin, alliuocide G, 2-(3,4-Dihydroxybenzoyl)-2,4,6-trihydroxy-3 (2H)-benzofuranone, Luteolin-7-O-D-glucopyranoside, quercetin, 1,3,11α-Trihydroxy-9-(3,5,7-trihydroxy-4H-1-benzopyran-7-on-2-yl)-5α-(3,4-dihydroxy-phenyl)-5,6,11-hexahydro-5,6,11-trioxanaphthacene-12-one and [1,3,11α-Trihydroxy-9-(3,5,7-trihydroxy-4H-1-benzopyran-7-on-2-yl)-5α-(3,4-dihydroxy-phenyl)-5,6,11-hexahydro-5,6,11-trioxanaphthacene-12-one]-4′-O-D-gluco-pyranoside from Allium cepa have been found to exhibit significant antidiabetic activities. With the huge number of adults living with diabetes in Kenya and the available treatment methods being expensive yet not so effective, this study highlights alternative remedies by documenting the commonly used antidiabetic medicinal plants. Further, the study supports the antidiabetic use of these plants with the existing pharmacological profiles and highlights research study gaps. Therefore, it is urgent to conduct natural products isolation work on the selected antidiabetic species commonly used in Kenya and evaluate their antidiabetic activities, both in vitro and in vivo, to validate their antidiabetic use and come up with new antidiabetic drugs.

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“…Traditional medicine practitioners of Kenya use various plants such as Pentas zanzibarica (Klotzsch) Vatke and Olea europaea subspecies africana (Mill.) to treat DM [24][25][26][27][28].…”

Section: Introductionmentioning

confidence: 99%

In Vivo Antidiabetic Efficacy, Mineral Element Composition, and Qualitative Phytochemistry of the Aqueous Leaf Extracts of Pentas zanzibarica (Klotzsch.) Vatke and Olea europaea subspecies africana (Mill.)

Moriasi

Kibiti

Ngugi

2021

Preprint

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Persistent hyperglycaemia is the hallmark of diabetes and is accountable for the devastating complications, which cause high morbidity and mortality. Conventional anti-diabetic agents are only palliative and characterised with limited efficacy, adverse effects, high costs, inaccessibility, prompting the need for better alternatives. Therefore, we investigated the in vivo hypoglycaemic activities, elemental composition, and qualitative phytochemistry of the aqueous leaf extracts of P. zanzibarica and O. europaea subspecies africana as potential sources of affordable, safer, accessible, and potent anti-diabetic therapies. In vivo hypoglycaemic activities of the studied plant extracts were evaluated at three dose levels of 50, 100, and 150 mg/Kg body weight (bw) in Alloxan-induced hyperglycaemic Swiss albino mice. The elemental composition of the plant extracts was analysed using the energy dispersive x-ray fluorescence spectroscopy (EDXRF System) and the atomic absorption spectrometry (AAS). Qualitative phytochemical screening was done following standard procedures. In this study, the aqueous leaf extract of P. zanzibarica, significantly (p<0.05) reduced alloxan-induced hyperglycaemia in mice from 163.26±2.24 mg/dL (at 0h) to 52.12±1.16 mg/dL (at the 4th h) at a dose of 50 mg/Kg body weight, 166.98±1.56 mg/dL (at 0h) to 48.90±1.40 mg/dL (at 4th h) at a dose of 100 mg/Kg body weight, and 168.64±2.96 mg/dL (at 0h) to 42.46±1.80 mg/dL (at 4th h) at a dose of 150 mg/Kg body weight, respectively. Similarly, the aqueous leaf extract of O. europaea subspecies africana significantly (p<0.05) reduced hyperglycaemia from 165.74±3.66 mg/dL (at 0h) to 65.26±1.46 mg/dL (at the 4th h) at a dose of 50 mg/Kg body weight, 158.14±3.49 mg/dL (at 0h) to 53.68±1.48 mg/dL (at the 4th h) at a dose of 100 mg/Kg body weight, and from 161.66±2.19 mg/dL (at 0h) to 44.48±1.35 mg/dL (at the 4th h) at a dose of 150 mg/Kg body weight, respectively Furthermore, the extracts contained chromium (Cr), zinc (Zn), magnesium (Mg), among other elements, and phytochemicals like phenols, flavonoids, and alkaloids, among others. Generally, the studied plant extracts exhibited significant hypoglycaemic efficacy in alloxan-induced hyperglycaemic mice, indicating their antidiabetic potential, and possess pharmacologically active phytochemicals and valuable minerals.

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Medicinal plants used in the management of diabetes by traditional healers of Narok County, Kenya

Cited by 6 publications

References 41 publications

Antimalarial Plants Used across Kenyan Communities

Antimalarial Plants Used across Kenyan Communities

Phytochemical Content and Antidiabetic Properties of Most Commonly Used Antidiabetic Medicinal Plants of Kenya

In Vivo Antidiabetic Efficacy, Mineral Element Composition, and Qualitative Phytochemistry of the Aqueous Leaf Extracts of Pentas zanzibarica (Klotzsch.) Vatke and Olea europaea subspecies africana (Mill.)

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