Medicinal plants used by Tanzanian traditional healers in the management of Candida infections

Runyoro, D.; Ngassapa, Olipa; Matee, Mecky; Joseph, Cosam C.; Moshi, Mainen J.

doi:10.1016/j.jep.2005.12.010

Cited by 68 publications

(44 citation statements)

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“…An ethnomedical survey of Coast, Dar es Salaam, Morogoro and Tanga regions of Tanzania resulted in the identification of 36 plant species belonging to 21 plant families that are used traditionally for the treatment of Candida infections that are an important sign of HIV/AIDS (Runyoro et al 2006). Some of the plants were reported to be active against other fungi including Cryptococcus neoformans (San Felice) Vuill., a major pathogenic fungus in HIV/AIDS.…”

Section: Research Statusmentioning

confidence: 99%

Traditional Knowledge, Use Practices and Conservation of Medicinal Plants for HIV/AIDS Care in Rural Tanzania

Kisangau

Herrmann²,

Lyaru

et al. 2011

Ethnobot. Res. App.

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Section: Research Statusmentioning

confidence: 99%

Traditional Knowledge, Use Practices and Conservation of Medicinal Plants for HIV/AIDS Care in Rural Tanzania

Kisangau

Herrmann²,

Lyaru

et al. 2011

Ethnobot. Res. App.

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“…In Africa and in other developing countries many people depend on medicinal plants because they have no access to modern medicines (Runyoro et al, 2006). The dependence on medicinal plants and traditional healers may be attributed to the low proportion of medical doctors to patients in Africa (South Africa 1:1 639; Ethiopia 1:33 000; Kenya 1:7 142; Tanzania 1:33 000; Uganda 1:25 000, Malawi 1:50 000; Mozambique 1:50 000; Swaziland 1:10 000) (Bekalo et al, 2009).…”

Section: Introductionmentioning

confidence: 99%

The traditional use of plants to manage candidiasis and related infections in Venda, South Africa

Masevhe

McGaw

Eloff

2015

Journal of Ethnopharmacology

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Ethnopharmacological relevance: This paper presents results of an ethnobotanical survey of medicinal plants used for the management of candidiasis and related fungal infections in the Venda area, South Africa. Materials and Methods:Ethnobotanical data about the uses of plants were gathered from eleven rural traditional healers using semi-structured interviews.Results: A total of 45 species belonging to 24 different families were identified, of which the dominant family was the Fabaceae with 13 species (28.9%) followed by the Asteraceae and Solanaceae with 3 species each (6.7 %). A total of 28 of these plant species (62.2%) have been shown to have anticandidal activity and 14 species (31%) have been recorded for antifungal uses in the literature. Amongst the 45 species recorded, 51% were trees, 33% were shrubs, and 16% were herbs. The most widely used plant species were Acacia caffra, Clerodendrum glabrum, Croton gratissimus, Elaeodendron transvaalense, Faurea saligna, Hippocratea longipetiolata, Osyris lanceolata, Richardia brasiliensis, Schkuhria pinnata, Schotia brachypetala, Spilanthes acmella, Strychnos potatorum, Vangueria infaustasubsp. infausta and Withania somnifera. The plant parts mostly used in the therapeutic preparations were roots (27.7%), bark (23.2%), and a combination of roots, bark (18.7%) and leaves (14.3%). Decoctions (44.4%), infusions (20%), macerations (17.7%), burning (11.4%) and paste (6.5%) were used. Most of the herbal remedies were administered orally. The main factors threatening the conservation status of these plants are unsustainable methods of harvesting, logging for firewood, building materials and crafts. Conclusion:The Venda area is rich in plant diversity and local indigenous knowledge of medicinal plants can play an important role as a model for low cost primary health care. Further studies are in progress to validate the indigenous plants recorded as traditional remedies in this area.

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“…This work had interesting results against Candida species. Candida albicans is the yeast species more often isolated from biological samples being an usual skin and mucosa colonizing agent with many hosts in the oral cavity, and higher incidence rates among young children and patients infected with HIV, but is necessary to pay attention to the emergence of other Candida species as infecting agents (McCullough et al, 1996;Runyoro et al, 2006;Zhang et al, 2006). Resistance to commonly used agents, toxicity and costs impelled the search for new agents and it can be noted that in recent years the research for new active compounds from natural sources has been increasing (Duarte et al, 2005;Runyoro et al, 2006).…”

Section: Resultsmentioning

confidence: 99%

Histochemical, phytochemical and biological screening of Plinia cauliflora (DC.) Kausel, Myrtaceae, leaves

Souza-Moreira¹,

Moreira²,

Sacramento³

et al. 2010

Rev. bras. farmacogn.

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RESUMO: "Rastreamento histoquímico, fitoquímico e biológico de folhas de Plinia cauliflora (DC.) Kausel (Myrtaceae)". No presente trabalho, foram investigadas a composição química e atividades biológicas de extratos brutos obtidos com etanol 50%, etanol 70%, acetona:água (7:3; v/v) e clorofórmio das folhas de Plinia cauliflora (DC.) Kausel, Myrtaceae, uma árvore nativa de várias regiões do Brasil. Os rastreamentos histoquímico e fitoquímico foram feitos de acordo com reações de caracterização e cromatografia em camada delgada. Para auxiliar na padronização dos extratos foram realizadas determinações do teor de fenóis totais e de flavonoides totais, espectrofotometricamente. A atividade antioxidante foi analisada pela porcentagem de sequestro de radicais livres usando solução de DPPH. A atividade antimicrobiana foi avaliada frente a bactérias patogênicas Gram-positivas, Gram-negativas e espécies de Candida utilizando os métodos de difusão em ágar e determinação da concentração inibitória mínima (MIC) de acordo com métodos padronizados. As folhas apresentaram lipídeos nas cavidades secretoras e fenóis, principalmente taninos, nas nervuras e parênquima paliçádico. Os extratos polares apresentaram flavonoides, taninos, alto teor de fenóis totais e de flavonoides totais. Os extratos mostraram elevada atividade antioxidante e a atividade antimicrobiana foi melhor contra as espécies de Candida do que contra as bactérias.Unitermos: Plinia cauliflora, Myrtaceae, rastreamento químico, atividade antioxidante, atividade antimicrobiana. ABSTRACT:In this work, chemical and biological activities of crude extracts obtained with 50% ethanol, 70% ethanol, acetone:water (7:3; v/v) and chloroform of Plinia cauliflora (DC.) Kausel, Myrtaceae, leaves, a native tree from several regions of Brazil, was investigated. Histochemical and phytochemical screenings were done according to characterization reactions and thin layer chromatography. To assist in extracts standardization, total phenol and flavonoids content spectrophotometric was performed. Antioxidant activity was analyzed by percentage of radical scavenging using DPPH solution. Antimicrobial activity was evaluated against Gram-positive, Gram-negative pathogenic bacteria and species of Candida using agar diffusion and minimal inhibitory concentration (MIC) determination methods according to standard methods. The leaves presented lipids at secretory cavity and phenols, mainly tannins, in nervures and palisade parenchyma. Polar extracts showed flavonoids, tannins and high content of phenols and flavonoids. The extracts showed great antioxidant activity and antimicrobial activity was better against Candida species than against bacteria.

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Medicinal plants used by Tanzanian traditional healers in the management of Candida infections

Cited by 68 publications

References 50 publications

Traditional Knowledge, Use Practices and Conservation of Medicinal Plants for HIV/AIDS Care in Rural Tanzania

Traditional Knowledge, Use Practices and Conservation of Medicinal Plants for HIV/AIDS Care in Rural Tanzania

The traditional use of plants to manage candidiasis and related infections in Venda, South Africa

Histochemical, phytochemical and biological screening of Plinia cauliflora (DC.) Kausel, Myrtaceae, leaves

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