Medicinal plants used against tuberculosis by traditional medicinal practitioners of Bogra district, Bangladesh

Rahman, Farjana; Hossan, Shahadat; Mollik, AH; Islam, Tahidul; Jahan, R; Taufiq-ur-Rahman, M.; Rahmatullah, Mohammed

doi:10.1055/s-0029-1234543

Cited by 3 publications

(2 citation statements)

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“…Several studies have shown the effectiveness of medicinal plants and their bioactive derivatives as a promising approach to TB treatment since these are naturally sourced compounds with minimal side effects [27][28][29][30]. Medicinal plants and their respective active compounds exhibit their anti-inflammatory mechanisms through inhibition of the NLRP3 inflammasome-associated transcripts [31,32], inflammasome assembly [33,34] and production of inflammasome proteins, including IL1 cytokines [35] in in vitro and in vivo M. tuberculosis infection models.…”

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confidence: 99%

Exploring the Use of Medicinal Plants and Their Bioactive Derivatives as Alveolar NLRP3 Inflammasome Regulators during Mycobacterium tuberculosis Infection

Mvubu

Chiliza

2021

IJMS

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Mycobacterium tuberculosis, the causative agent of tuberculosis (TB), is a successful intracellular pathogen that is responsible for the highest mortality rate among diseases caused by bacterial infections. During early interaction with the host innate cells, M. tuberculosis cell surface antigens interact with Toll like receptor 4 (TLR4) to activate the nucleotide-binding domain, leucine-rich-repeat containing family, pyrin domain-containing 3 (NLRP3) canonical, and non-canonical inflammasome pathways. NLRP3 inflammasome activation in the alveoli has been reported to contribute to the early inflammatory response that is needed for an effective anti-TB response through production of pro-inflammatory cytokines, including those of the Interleukin 1 (IL1) family. However, overstimulation of the alveolar NLRP3 inflammasomes can induce excessive inflammation that is pathological to the host. Several studies have explored the use of medicinal plants and/or their active derivatives to inhibit excessive stimulation of the inflammasomes and its associated factors, thus reducing immunopathological response in the host. This review describes the molecular mechanism of the NLRP3 inflammasome activation in the alveoli during M. tuberculosis infection. Furthermore, the mechanisms of inflammasome inhibition using medicinal plant and their derivatives will also be explored, thus offering a novel perspective on the alternative control strategies of M. tuberculosis-induced immunopathology.

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Section: Introductionmentioning

confidence: 99%

Exploring the Use of Medicinal Plants and Their Bioactive Derivatives as Alveolar NLRP3 Inflammasome Regulators during Mycobacterium tuberculosis Infection

Mvubu

Chiliza

2021

IJMS

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“…and Curcuma domestica are reported could medicate tuberculosis through isocitrate lyase and macrophage activity 46. Bangladesh and Indonesia have similarity in medical plants for tuberculosis, it is reported that Andrographis paniculata, Centella asiatica, Aloe vera, and Hibiscus rosa sinensis are used to treat Mycobacterium tuberculosis infection 47. Analysis of active compounds target networkThrough Dr. Duke's Phytochemical and Ethnobotanical Databases active compounds of the medical plants were obtained from the database.…”

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Network Analysis of Indigenous Indonesia Medical Plants for Treating Tuberculosis

Aristyani¹,

Widyarti²,

Sumitro³

2018

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Background: Indonesia is the biggest archipelago country with the second biggest biodiversity in the world. A lot of medical plants for treating various diseases can be found in Indonesia, including medical plants for tuberculosis, an infectious disease caused by Mycobacterium tuberculosis. Objective: The goal of this research is to document the information of Indonesia indigenous medical plants that used various local societies to treat tuberculosis and also analyze active compounds of medical plants with proteins that related to tuberculosis. Methods and Materials: The annotation of medical plants for treating tuberculosis was collected from a various source comprising local research papers, theses, and other resources. The information of active compound was taken from Dr. Duke's Phytochemical and Ethnobotanical Databases. A network of active compounds-proteins was analyzed by using Cytoscape 3.6.0. Results: The result described that there were twenty-seven species from nineteen families of medical plants used by local societies of Indonesia for tuberculosis therapy, and there were sundry of active compounds from fourteen medical plants had direct interaction with proteins related tuberculosis. Conclusion: Most of the active compounds targeted proteins that had a prominent role in immune system. It indicated that medical plants treating tuberculosis through regulating immunity of human body. ABSTRACT SUMMARY • Tuberculosis is a respiratory infectious disease caused by Mycobacterium tuberculosis. For a long time, Indonesia local societies have been used medical plants for tuberculosis therapy. By using network analysis study, the active compounds of medical plants can modulate human immunity to treat tuberculosis. Sherry Aristyani, a master student of Biology in Faculty of Mathematics and Natural Sciences, University of Brawijaya. Her master research focuses on active compounds of Indonesia medical plants for tuberculosis therapy. Sri Widyarti, Lecturer and researcher in Faculty of Mathematics and Natural Sciences, University of Brawijaya. She has expertise in biology cell. Sutiman Bambang Sumitro, a professor in Department of Biology, Faculty of Mathematics and Natural Sciences, University of Brawijaya. He has expertise in biology cell, bioinorganic, and nano-biology. ABOUT AUTHORS

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Some Plant species of Tarai region of Kumaun, Uttarakhand, used in tuberculosis

Mathur

Joshi

2015

J. Non-Timber Forest Prod.

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Tuberculosis (TB) remains one of the most difficult ailments to control in the world today. The emergence of drug resistant strains has made previously effective and affordable remedies less effective (There are more than twenty drugs that are currently used for the treatment of TB and almost all of them were developed some years ago. The drugs are used in differing combinations in different circumstances, so that for example some TB drugs are only used for the treatment of new patients who are very unlikely to have resistance to any of the TB drugs). This has made the search for new medicines from local traditional medicines. The specific objectives of this study were to identify plant species used in the treatment of TB, parts used, their methods of preparation and administration. The present study was conducted in the central tarai region of Kumaun, Uttarakhand in the year 2008-2011. Total fifteen plant species were found to be used to cure tuberculosis. The different use of Adhatoda vasica was reported first time from the study area. Species Albizia lebbeck, Bauhinia variegata, Baliospermum montanum, Sida rhombifolia, Withania somnifera, Asclepias curassavica, Echinops echinatus, and Saccharum spontaneum were reported first time of the study area.

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Medicinal plants used against tuberculosis by traditional medicinal practitioners of Bogra district, Bangladesh

Cited by 3 publications

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Exploring the Use of Medicinal Plants and Their Bioactive Derivatives as Alveolar NLRP3 Inflammasome Regulators during Mycobacterium tuberculosis Infection

Exploring the Use of Medicinal Plants and Their Bioactive Derivatives as Alveolar NLRP3 Inflammasome Regulators during Mycobacterium tuberculosis Infection

Network Analysis of Indigenous Indonesia Medical Plants for Treating Tuberculosis

Some Plant species of Tarai region of Kumaun, Uttarakhand, used in tuberculosis

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