Medicinal plants: Traditions of yesterday and drugs of tomorrow

Gurib-Fakim, Ameenah

doi:10.1016/j.mam.2005.07.008

Cited by 1,694 publications

(1,177 citation statements)

References 62 publications

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“…Medicinal plants play an important role in the discovery and isolation of new drugs, as has been the case for morphine, digitoxin, quinine, reserpine and pilocarpine (Balunas and Kinghorn, 2005;Gurib-Fakim, 2006). Consequently, there is a clear indication that this is a viable path of clinical innovation, as 6 evidenced by some plant species from the Helichrysum Miller genus (family Asteraceae).…”

Section: Introductionmentioning

confidence: 99%

Helichrysum italicum: From traditional use to scientific data

Viegas¹,

Palmeira‐de‐Oliveira²,

Salgueiro³

et al. 2014

Journal of Ethnopharmacology

132

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Ethnopharmacological relevanceHelichrysum italicum (Roth) G. Don fil. (family Asteraceae) has been used for its medicinal properties for a long time and, even nowadays, continues to play an important role in the traditional medicine of Mediterranean countries. Based on this traditional knowledge, its different pharmacological activities have been the focus of active research. Aim of the reviewTo provide an overview of the current state of knowledge of the pharmacological activities of H. italicum, as well as its traditional uses, toxicity, drug interactions and safety. Materials and methodsThe selection of relevant data was made through a search using the keywords "Helichrysum italicum" and "H. italicum" in "Directory of Open Access Journals", "Google Scholar", "ISI Web of Knowledge", "PubMed", "ScienceDirect" and "Wiley Online Library". Information obtained in local and foreign books and other sources was also included. ResultsThere are reports on the traditional use of H. italicum in European countries, particularly Italy, Spain, Portugal and Bosnia and Herzegovina. In these countries, its flowers and leaves are the most used parts in the treatment of health disorders such as allergies, colds, cough, skin, liver and gallbladder disorders, inflammation, infections and sleeplessness. In order to validate some of the traditional uses of H. italicum italicum in vivo activity, the highlight goes to the anti-erythematous and photoprotective activities of its flavonoids, demonstrated both in animals and humans, and to the anti-inflammatory properties exhibited by its flavonoids, acetophenones and phloroglucinols, as seen in animal models. Concerning its safety and adverse effects, while H. italicum does not display significant levels of cytotoxicity or genotoxicity, it should be noticed that one of its flavonoids inhibited some CYP isoforms and a case has been reported of an allergic reaction to its extracts. Aim of the reviewTo provide an overview of the current state of knowledge of the pharmacological activities of H. italicum, as well as its traditional uses, toxicity, drug interactions and safety. Materials and methodsThe selection of relevant data was made through a search using the keywords "Helichrysum italicum" and "H. italicum" in "Directory of Open Access Journals", "Google Scholar", "ISI Web of Knowledge", "PubMed", "ScienceDirect" and "Wiley Online Library". Information obtained in local and foreign books and other sources was also included. ResultsThere are reports on the traditional use of H. italicum in European countries, particularly Italy, Spain, Portugal and Bosnia and Herzegovina. In these countries, its flowers and leaves are the most used parts in the treatment of health disorders such as allergies, colds, cough, skin, liver and gallbladder disorders, italicum in vivo activity, the highlight goes to the anti-erythematous and photoprotective activities of its flavonoids, demonstrated both in animals and humans, and to the anti-inflammatory properties exhibited by its flavonoids, acet...

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Section: Introductionmentioning

confidence: 99%

Helichrysum italicum: From traditional use to scientific data

Viegas¹,

Palmeira‐de‐Oliveira²,

Salgueiro³

et al. 2014

Journal of Ethnopharmacology

132

View full text Add to dashboard Cite

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“…Therefore, the search for a new class of therapeutic agents is critical and pressing (Calugi et al 2011). Natural products, medicinal plants, and their derivatives have been used as new sources of alternative therapies to treat or relieve diseases (Gurib-Fakin 2006). T. vulgaris is an essential oil with various potent biological activities, including antimicrobial, antioxidant, and anti-inflammatory activities (Tsai et al 2011).…”

Section: Discussionmentioning

confidence: 99%

Viable quantitative PCR for assessing the response of Candida albicans to antifungal treatment

Agustí

Fittipaldi

Morató

et al. 2012

Appl Microbiol Biotechnol

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“…Once the cell looses control over apoptotic mechanism, cell evades death and divides continuously leading to neoplastic transformation (Igney and Krammer 2002;Hu and Kavanagh 2003;Reed 2003;Qi et al 2010). Since ages, natural products are utilized in the traditional health care medicinal practices from centuries (Akerele 1988;Gurib-Fakim 2006). Plants are only sources which account for providing medicine or medicinal formulations for treating 80 % world population (Owoabi et al 2007).…”

Section: Introductionmentioning

confidence: 99%

Antiproliferative and Apoptosis Inducing Effects of Non-Polar Fractions from Lawsonia inermis L. in Cervical (HeLa) Cancer Cells

Kumar

Kaur

Kumar

et al. 2015

Physiol Mol Biol Plants

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Two non-polar fractions viz. hexane (Hex-LI) and chloroform fraction (CHCl 3 -LI) of Lawsonia inermis were studied for their antiproliferative potential in various cancer cell lines viz. HeLa, MCF-7, A549 and C6 glioma cells. Both the fractions showed more than 60 % of growth inhibition in all the tested cell lines at highest tested concentration. In clonogenic assay, different concentrations of Hex-LI and CHCl 3 -LI decreased the number and size of colonies as compared to control in HeLa cells. The apoptotic effects as nuclear condensation, fragmentation were visualized with Hoechst-33342 staining of HeLa cells using confocal microscope. Both fractions induced apoptotic cell death in human cervical carcinoma (HeLa) cells as evident from flow cytometric analysis carried out using Annexin V-FITC and propidium iodide dyes. CHCl 3 -LI treated cells significantly induced apoptosis (25.43 %) in comparison to control. Results from Neutral Comet assay demonstrated that both fractions induced double stranded breaks (DSB's) in HeLa cells. Our data indicated that Hex-LI and CHCl 3 -LI treated cells showed significant increase of 32.2 and 18.56 % reactive oxygen species (ROS) levels in DCFH-DA assay respectively. Further, experimental studies to decipher exact pathway via which these fractions induce cell death are in progress.

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Medicinal plants: Traditions of yesterday and drugs of tomorrow

Cited by 1,694 publications

References 62 publications

Helichrysum italicum: From traditional use to scientific data

Helichrysum italicum: From traditional use to scientific data

Viable quantitative PCR for assessing the response of Candida albicans to antifungal treatment

Antiproliferative and Apoptosis Inducing Effects of Non-Polar Fractions from Lawsonia inermis L. in Cervical (HeLa) Cancer Cells

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