Medicinal plants possessed antioxidant and free radical scavenging effects (part 3)- A review

Al-Snafi, Ali Esmail

doi:10.9790/3013-0704014862

Cited by 18 publications

(14 citation statements)

References 57 publications

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“…In the estimation of DPPH free radicals scavenging activities, a positive correlation was observed between the flavonoid and phenolic content of the D. metel extracts [8,42]. Maximum DPPH scavenging activity of methanolic seed extracts of D. stramonium was found to be 59.50% at a concentration of 60 µg/mL with IC 50 value of 94.87 µg/mL; similarly, the maximum superoxide radical scavenging activity was 53.17% at a concentration of 60 µg/mL, while maximum scavenging activity of hydroxyl radical was 57.88% at concentration of 30 µg/mL with IC 50 value of 39.59 µg/mL [41].…”

Section: Antioxidation Activitiesmentioning

confidence: 94%

“…Analysis of Datura plant extracts for antioxidant characteristics revealed its ability to cure various health disorders, including cancers, since antioxidants are known to inhibit cell damage, the general pathway for cancers, aging, and several other diseases [41]. The antioxidant capacity of leaf extracts in different solvents, estimated by various in vitro methods, including hydroxyl radical scavenging activity, DPPH (2,2-diphenyl-1-picrylhydrazyl) scavenging activity, superoxide radical scavenging activity, β-carotene bleaching activity, and reducing power assay, revealed that chloroform extract of leaves possessed maximum concentration-dependent antioxidant activity [42,43]. The IC 50 value of methanolic and hydroalcoholic seed extracts of D. metel recorded using the DPPH model showed that hydroalcoholic extract possesses slightly higher antioxidant activities (IC 50 of 25.78 µg/mL) than methanolic seed extract (IC 50 of 28.34 µg/mL) [7,42].…”

Section: Antioxidation Activitiesmentioning

confidence: 99%

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Phytochemistry, Pharmacology, and Toxicology of Datura Species—A Review

et al. 2021

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Datura, a genus of medicinal herb from the Solanaceae family, is credited with toxic as well as medicinal properties. The different plant parts of Datura sp., mainly D. stramonium L., commonly known as Datura or Jimson Weed, exhibit potent analgesic, antiviral, anti-diarrheal, and anti-inflammatory activities, owing to the wide range of bioactive constituents. With these pharmacological activities, D. stramonium is potentially used to treat numerous human diseases, including ulcers, inflammation, wounds, rheumatism, gout, bruises and swellings, sciatica, fever, toothache, asthma, and bronchitis. The primary phytochemicals investigation on plant extract of Datura showed alkaloids, carbohydrates, cardiac glycosides, tannins, flavonoids, amino acids, and phenolic compounds. It also contains toxic tropane alkaloids, including atropine, scopolamine, and hyoscamine. Although some studies on D. stramonium have reported potential pharmacological effects, information about the toxicity remains almost uncertain. Moreover, the frequent abuse of D. stramonium for recreational purposes has led to toxic syndromes. Therefore, it becomes necessary to be aware of the toxic aspects and the potential risks accompanying its use. The present review aims to summarize the phytochemical composition and pharmacological and toxicological aspects of the plant Datura.

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Section: Antioxidation Activitiesmentioning

confidence: 94%

Section: Antioxidation Activitiesmentioning

confidence: 99%

Phytochemistry, Pharmacology, and Toxicology of Datura Species—A Review

et al. 2021

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“…Various antioxidant systems are produced by the body for ROS detoxi ication. This disparity between the free radicals and antioxidants are supposed to cause many in lammatory pathologies (Al-Sna i, 2017). Valuation of the levels of antioxidant enzyme activities such as those of CAT, SOD, and glutathione help to measure the antioxidant status of the extract (Cimen et al, 2003;Babaee et al, 2016).…”

Section: Resultsmentioning

confidence: 99%

Effect of Tagetes erecta flower and leaf extract gel on oxidative stress and antioxidant levels in oral ulcer condition

Lakshana¹,

Vijayalakshmi²,

Jayakumar³

et al. 2020

ijrps

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An oral ulcer is described by repeated or painful oral aphthae, in which oxidative stress apparently leads to its pathogenesis. The present study has been undertaken to evaluate the effects of fresh leaves and flowers of Tagetes erecta gel on oxidative stress and antioxidant levels on oral ulcer models in albino Wistar rats. The oral ulcer was induced by incision wound model and then treated with the Tagetes erecta flower and leaf extract gel for 7 days. The antioxidant activities of catalase (CAT), superoxide dismutase (SOD), the levels of glutathione (GSH) and malondialdehyde (MDA) were measured in rat buccal mucosal tissues. The antiulcer effects of Tagetes erecta leaf and flower extracts (2.5% and 5%) gel were intercompared with the standard drug, Triamcinolone. Ulcer induced rats exhibited elevated levels of MDA and reduced activity of SOD, GSH and CAT when compared to the control rats. The nonequilibrium levels of antioxidant were observed in rat mucosal tissues indicate that body’s antioxidant status was depleted with an oral ulcer. Tagetes erecta leaf and flower gel (5%) has been found to have higher significant antioxidant activity compared with ulcer induced rats by reducing the levels of MDA and by increasing the activities of SOD, GSH and CAT in response to oxidative stress due to induction of oral ulcers in a rat model. The findings thus justify the traditional use of Tagetes erecta to heal oral ulcer by increasing the antioxidant status and decreasing the free radical production.

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“…Dermatology: It has been deeply studied that plants provide beneficial effects to humans due to their antimicrobial 3,13,44 , antioxidants [45][46][47] , among others properties, which are attributed to their secondary metabolites 48 . However, phytochemical effectiveness on skin can be conditioned by environment characteristics, compound degradation rate or other physicochemical drawbacks 49 .…”

Section: Anti-inflammatory and Antioxidant Activitymentioning

confidence: 99%

Untitled

2022

IJPSR

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An extensive range of studies have shown plant extracts and their phyto-constituents efficacy, proposing them as a promising alternative for treatment or as adjuvants in human diseases such in skin, gastrointestinal, systemic and dental conditions, due to various active components presence, ease of access and reduced side effects. Indeed, depending on solvent used to obtain the extract, its active molecules may vary, including flavonoids, tannins, alkaloids, terpenes, sesquiterpenes, sterols, among others. Extract content (crude/partition/fraction) has pharmacological advantages over isolated compounds, due to pleiotropic activity and synergistic effect between components. Due to factors such as low bioavailability, solubility, and stability, it is difficult to translate its in-vitro and in-vivo effects into clinical picture, besides that pharmacological effects full potential cannot be exploited. However, in recent decades, extraordinary advances have been made in new drug delivery systems for the encapsulation of active plant metabolites, thus helping to improve different medicinal plant-based therapies and product efficacy. The current review highlights the importance of nanocarriers loaded with plant extracts as an alternative for dental, dermatological, gastrointestinal, and systemic diseases.

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Medicinal plants possessed antioxidant and free radical scavenging effects (part 3)- A review

Cited by 18 publications

References 57 publications

Phytochemistry, Pharmacology, and Toxicology of Datura Species—A Review

Phytochemistry, Pharmacology, and Toxicology of Datura Species—A Review

Effect of Tagetes erecta flower and leaf extract gel on oxidative stress and antioxidant levels in oral ulcer condition

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