Medicinal Plants of the Genus Sapindus (Sapindaceae) - A Review of Their Botany, Phytochemistry, Biological Activity and Traditional Uses

Goyal, Sachin

doi:10.22270/jddt.v4i5.949

Cited by 8 publications

(4 citation statements)

References 45 publications

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“…Sapindus mukorossi of Sapindaceae family, commonly famous for soapnut, washnut, reetha, or ritha, is a well-known, handsome, deciduous, and valuable tree species. It is indigenous to the hilly areas of China and Japan below an altitude of 1000 m and is widely cultivated in North India [1,2]. As it is rich in valuable saponins (possessing the property of outstanding surface activity), S. mukorossi is an ecofriendly and promising alternative material of biosurfactant for producing shampoos, cosmetic cleansers, and detergents in sanitary and cosmetic products [3].…”

Section: Introductionmentioning

confidence: 99%

Optimization of Microwave-Assisted Extraction Saponins from Sapindus mukorossi Pericarps and an Evaluation of Their Inhibitory Activity on Xanthine Oxidase

Deng

Liu

Zou

2019

Journal of Chemistry

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A microwave-assisted extraction (MAE) method was applied to separate saponins from Sapindus mukorossi pericarps. The most important factors of the six extraction parameters were selected using Plackett–Burman designs; therefore, the further extraction procedure was optimized using the Box–Behnken designs; meanwhile, the optimum processing parameters and well-pleasing saponins extraction rate were inferred. The final operation conditions were the ethanol concentration of 40%, soaking time of 3 h, particle size of 80–100 meshes, extraction time of 13 min, solvent-solid ratio of 19 mL/g, and microwave power of 425 W. Based on the optimal extraction parameters, the extraction rate of the saponins by means of MAE technique reached 280.55 ± 6.81 mg/g, which exceeds yields acquired using conventional manners. Saponins from S. mukorossi have obvious xanthine oxidase inhibitory properties in vitro compared with allopurinol. The saponins displayed a type of competitive inhibition of xanthine oxidase. In conclusion, a MAE technique in association with a response surface design provides an efficient extraction tactics, which could sufficiently isolate saponins from S. mukorossi pericarps; further, this technique could be applied to the dissociation of other bioactive substances from plant sources. In addition, the saponins may be a promising alternative to conventional medicine to treat gout and other inflammation-associated disorders to mitigate the side effects of traditional drugs.

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Section: Introductionmentioning

confidence: 99%

Optimization of Microwave-Assisted Extraction Saponins from Sapindus mukorossi Pericarps and an Evaluation of Their Inhibitory Activity on Xanthine Oxidase

Deng

Liu

Zou

2019

Journal of Chemistry

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“…2 Recent investigational studies on S. saponaria L. has revealed a number of properties of this plant which includes anti-oxidant, hepatoprotective, anti-inflammatory, anti-cancer, anxiolytic, fungicidal, spermicidal etc. 3,4 The ethyl acetate and hexane extract of S. saponaria L. also showed inhibitory effect against human skin cancer cell lines (A375.S2, MeWo), lung(A549, NCI-H460), liver cancer cell line (HepG2,PLC/PRF/5) prostate cancer cell lines (PC-3, Du-145, LNCaP)), cervical cancer cell lines (HeLa), bone cancer cell line(MG-63), bladder cell line (T24) , and breast cancer cell lines(MDA-MB-231, Hepa 59T/VGH, NCL, Med).It has been found that ethyl acetate and hexane extract of S. saponaria L. shows effective inhibitory activity against all the mentioned cell lines and especially against lung cancer and melanoma cell line. 5 But no detailed work has been done on hepatocellular carcinoma (HepG2 and Huh-7) cell lines so far.…”

Section: Introductionmentioning

confidence: 99%

Phytochemical Analysis and Growth Suppressing Activity of Sapindus saponaria L. Pericarp Extract on Hepatocellular Carcinoma Cells

Roy¹,

Kumar²,

Besra³

2020

IJPSRR

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Sapindus saponaria L. has revealed a number of properties of this plant which includes antioxidant, hepatoprotective, antiinflammatory, anti-cancer, anxiolytic, fungicidal, spermicidal activity. The present study investigated the anti-cancer activity of Sapindus saponaria L. pericarp extract (SSFE) on hepato carcinoma cell lines. The extract and fractions significantly inhibited cell the viability in a time and concentration dependent manner in both the carcinoma cells. Morphological study showed several signs of apoptosis like chromatin condensation, nuclear fragmentation and formation of apoptotic bodies and degraded DNA bands in both the treated hepatoma cells than control. Treated cells exerted significant MMP shift in the mitochondrial transmembrane potential activity involving the release of cytochrome c into the cytosol. The cell cycle phase arrest was observed in the G0/G1 phase change in the EFESS treated cells. These findings suggest that extracts possess cytotoxic and apoptosis activity against both the hepatocellular carcinoma cells. Further mechanistic studies are under process to determine the different pathways attributing to apoptosis.

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“…It may be possible that the bioactive compounds within the plant may not be the solitary product of the plant, but products of the microbes that exist in association with the host plant [10]. The selected medicinal plants are Sapindus trifoliatus, Millettia pachycarpa, Oroxylum indicum, and an unidentified vine plant which is used in traditional fermentation [11,12]. S. trifoliatus has been used for the treatment of ulcers, external wounds, inflammation, epilepsy, dental caries, arthritis, joint pain, gout and rheumatism.…”

Section: Introductionmentioning

confidence: 99%

“…S. trifoliatus has been used for the treatment of ulcers, external wounds, inflammation, epilepsy, dental caries, arthritis, joint pain, gout and rheumatism. The crude extracts possess antimicrobial, anticancer, spermicidal, hepatoprotective, antioxidant, antiinflammatory, anti-platelet aggregation, anti-hyperlipidemic, anti-migraine, anti-diabetic, anti-ulcerogenic and analgesic properties [11]. O. indicum has been used for the prevention and treatment of jaundice, arthritic and rheumatic problems, gastric ulcers, tumors, respiratory diseases, diabetes, and diarrhea and dysentery [12].…”

Section: Introductionmentioning

confidence: 99%

Screening of Endophytes from Traditionally Used Medicinal Plants of Manipur for Their Antimicrobial Activity An Impact towards Future Drug Discovery

Ngashangva¹,

S²,

Kalita³

2019

IJSRBS

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Antimicrobial resistance has been developing fast and continuing to challenge the world medical sector. New strategies are needed to address this challenge that is incurring huge loss on human life. Medicinal plants from the untapped rainforest of the North-East India has a huge potential to find microbes that produce novel biomolecules. Bioactive endophytes were isolated from traditionally used medicinal plants. Paenibacillus spp. from Millettia spp. in a fermentation broth has shown strong and broad-spectrum of activity at the range of 1600 AU/ml. Unexplored region has huge prospect to find novel biomolecules which can be harvested in scientific, economical and environmentally friendly. Moreover, it has shown that the traditional medicinal plant harboured bioactive. Moreover, it will provide insights into its metabolic potential and ecological role of this species.

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Medicinal Plants of the Genus Sapindus (Sapindaceae) - A Review of Their Botany, Phytochemistry, Biological Activity and Traditional Uses

Cited by 8 publications

References 45 publications

Optimization of Microwave-Assisted Extraction Saponins from Sapindus mukorossi Pericarps and an Evaluation of Their Inhibitory Activity on Xanthine Oxidase

Optimization of Microwave-Assisted Extraction Saponins from Sapindus mukorossi Pericarps and an Evaluation of Their Inhibitory Activity on Xanthine Oxidase

Phytochemical Analysis and Growth Suppressing Activity of Sapindus saponaria L. Pericarp Extract on Hepatocellular Carcinoma Cells

Screening of Endophytes from Traditionally Used Medicinal Plants of Manipur for Their Antimicrobial Activity An Impact towards Future Drug Discovery

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