Medicinal plants of Tamil Nadu (Southern India) are a rich source of antiviral activities

Vimalanathan, Selvarani; Ignacimuthu, Savarimuthu; Hudson, J. B.

doi:10.1080/13880200902800196

Cited by 70 publications

(53 citation statements)

References 16 publications

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“…Indian preventive and prophylactic medicinal plants recommended by AYUSH for COVID-19 (Table 4). Also, other studies on coronavirus using medicinal plants are rather minimal in India, a study has shown anti-mouse coronaviral activity (a surrogate of SARS-CoV) by the plants Indigofera tinctoria (AO), Vitex trifolia, Gymnema sylvestre, Abutilon indicum, Leucas aspera, Cassia alata, Sphaeranthus indicus, Clitoriaternatea, Clerodendruminerme Gaertn, Pergulariadaemi and Evolvulus alsinoides in Tamil Nadu (Vimalanathan et al, 2009). Among them Vitex trifolia and Sphaeranthus indicus have been found to reduce inflammatory cytokines using the NF-kB pathway, a pathway that has been implicated in respiratory distress in SARS-CoV (Alam et al, 2002;Srivastava et al, 2015).…”

Section: Indian Medicinal Plants and Their Possible Effect On Covid-19mentioning

confidence: 99%

COVID-19: A promising cure for the global panic

Vellingiri

Jayaramayya

Iyer

et al. 2020

Science of The Total Environment

565

538

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Journal Pre-proof J o u r n a l P r e -p r o o f Acknowledgements: AbstractThe novel Coronavirus disease 2019 is caused by SARS-CoV-2, which is the causative agent of a potentially fatal disease that is of great global public health concern. The outbreak of COVID-19 is wreaking havoc worldwide due to inadequate risk assessment regarding the urgency of the situation. The COVID-19 pandemic has entered a dangerous new phase. When compared with SARS and MERS, COVID-19 has spread more rapidly, due to increased globalization and adaptation of the virus in every environment. Slowing the spread of the COVID-19 cases will significantly reduce the strain on the healthcare system of the country by limiting the number of people who are severely sick by COVID-19 and need hospital care. Hence, the recent outburst of COVID-19 highlights an urgent need for therapeutics targeting SARS-CoV-2. Here, we have discussed the structure of virus; varying symptoms among COVID-19, SARS, MERS and common flu; the probable mechanism behind the infection and its immune response. Further, the current treatment options, drugs available, ongoing trials and recent diagnostics for COVID-19 have been discussed.We suggest traditional Indian medicinal plants as possible novel therapeutic approaches, exclusively targeting SARS-CoV-2 and its pathways.

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Section: Indian Medicinal Plants and Their Possible Effect On Covid-19mentioning

confidence: 99%

COVID-19: A promising cure for the global panic

Vellingiri

Jayaramayya

Iyer

et al. 2020

Science of The Total Environment

565

538

View full text Add to dashboard Cite

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“…[57] The plant extract also exhibited antiviral activity against vaccinia and ranikhet viruses. [58]…”

Section: Pharmacological Activitymentioning

confidence: 99%

Sphaeranthus indicus Linn.: A phytopharmacological review

Galani¹,

Patel²,

Rana³

2010

Int J Ayurveda Res

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Sphaeranthus indicus Linn. (Asteraceae) is widely used in Ayurvedic system of medicine to treat vitiated conditions of epilepsy, mental illness, hemicrania, jaundice, hepatopathy, diabetes, leprosy, fever, pectoralgia, cough, gastropathy, hernia, hemorrhoids, helminthiasis, dyspepsia and skin diseases. There are reports providing scientific evidences for hypotensive, anxiolytic, neuroleptic, hypolipidemic, immunomodulatory, antioxidant, anti-inflammatory, bronchodialatory, antihyperglycemic and hepatoprotective activities of this plant. A wide range of phytochemical constituents have been isolated from this plant including sesquiterpene lactones, eudesmenolides, flavanoids and essential oil. A comprehensive account of the morphology, phytochemical constituents, ethnobotanical uses and pharmacological activities reported are included in this review for exploring the immense medicinal potential of this plant.

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“…It is used to treat fever, epilepsy, mental illness, hemicranias, jaundice, hepatopathy, gastropathy, hernia, diabetes, pectoralgia, cough, hemorrhoids, leprosy, helminthiasis, dyspepsia and skin diseases [10]. Several scientific reports are available on S. indicus exhibiting hypotensive, peripheral vasodilatory, cathartic [13], antimicrobial [14], nematocidal [15], larvicidal [16,17], antiinflammatory [18], immunomodulatory [19], anxiolytic [20], neuroleptic [21,22], antioxidant [23,24], antihyperglycemic [25,26], analgesic, antipyretic [27], mast cell stabilizing action [28], renoprotective [29], hepatoprotective [24,30], antiviral [25,31], macrofilaricidal [32], sedative [22], bronchodilatory [33] and antihyperlipidemic activities [34].…”

Section: Introductionmentioning

confidence: 99%

Comparative assessment of antimicrobial and antioxidant activity between whole plant and parts of Sphaeranthus indicus Linn. (Asteraceae)

Tandon

Gupta

2020

Clin Phytosci

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Background: Sphaeranthus indicus is an important medicinal plant, which is used to cure various illnesses. The present study is the first investigation of the antimicrobial, antioxidant and phytochemical analysis of Sphaeranthus indicus from Chhattisgarh, India. Methods:The whole plant and plant parts were extracted with polar and non-polar solvents such as water, methanol, ethyl acetate and hexane to assess various bioactivities. The antimicrobial and antioxidant activities were performed by ager well diffusion method and ferrous reducing capacity, respectively; However free radical scavenging activity was analyzed using DMPD and DPPH scavenging assay. The DMPD and DPPH assay were performed in a time dependent manner. Qualitative and quantitative analysis were performed for the total phytochemicals present in the plant extracts. The total content of phenols, flavonoids and terpenoids was analyzed by colorimetric methods.Results: Ethyl acetate and hexane extract of plant inflorescence and stem exhibited significant antibacterial activity against tested bacterial pathogens. The clinically isolated gram positive pathogenic bacteria responded better as compared to clinically isolated gram negative bacteria as well as pathogenic gram positive and negative bacteria acquired from Microbial Type Culture Collection, India. The leaf and inflorescence exhibited potent antioxidant activity. The polar fraction of leaf methanol extract exhibited the highest reducing power capacity. The aqueous extract of inflorescence exhibited highest inhibition against DMPD and DPPH radicals. The whole plant aqueous extract showed maximum inhibition while aqueous extract of inflorescence exhibited high inhibition among different plant parts. Qualitative phytochemical analysis revealed the presence of terpenoids, phenols, flavonoids, tannins and cardiac glycosides in plant parts. Total terpenoid content was found to be highest in polar fraction of stem methanol extract and ethyl acetate extract of inflorescence. However, total phenol was found to be highest in polar fraction of leaf methanol extract, similarly highest flavonoid content was observed in aqueous extract of leaf. Conclusion:The results suggest that biological activities of plant parts depend on content of active phytochemicals. The inflorescence could be a potential source of antimicrobial and antioxidant compound. Further, investigation pertaining isolation and characterization of active ingredient may provide an insight regarding its phytochemical activity.

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Medicinal plants of Tamil Nadu (Southern India) are a rich source of antiviral activities

Cited by 70 publications

References 16 publications

COVID-19: A promising cure for the global panic

COVID-19: A promising cure for the global panic

Sphaeranthus indicus Linn.: A phytopharmacological review

Comparative assessment of antimicrobial and antioxidant activity between whole plant and parts of Sphaeranthus indicus Linn. (Asteraceae)

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