Medicinal Plants for Anti-neurodegenerative diseases in West Africa

Ayeni, Emmanuel Ayodeji; Gong, Yuzhou; Yuan, Hao; Hu, Yi‐Kao; Bai, Xiao-Bo; Liao, Xun

doi:10.1016/j.jep.2021.114468

Cited by 27 publications

(18 citation statements)

References 221 publications

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“…Neurodegenerative diseases are a leading cause of death and affect a huge number of people worldwide [ 37 ]. Moreover, it is known that some toxicants may cause or/and hasten neuronal senescence [ 38 ].…”

Section: Discussionmentioning

confidence: 99%

Cytotoxicity and Effects on the Synapsis Induced by Pure Cylindrospermopsin in an E17 Embryonic Murine Primary Neuronal Culture in a Concentration- and Time-Dependent Manner

Hinojosa

Prieto

Muñoz-Castro

et al. 2022

Toxins

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Cylindrospermopsin (CYN) is a cyanotoxin whose incidence has been increasing in the last decades. Due to its capacity to exert damage at different levels of the organism, it is considered a cytotoxin. Although the main target organ is the liver, recent studies indicate that CYN has potential toxic effects on the nervous system, both in vitro and in vivo. Thus, the aim of the present work was to study the effects of this cyanotoxin on neuronal viability and synaptic integrity in murine primary cultures of neurons exposed to environmentally relevant concentrations (0–1 µg/mL CYN) for 12, 24, and 48 h. The results demonstrate a concentration- and time-dependent decrease in cell viability; no cytotoxicity was detected after exposure to the cyanotoxin for 12 h, while all of the concentrations assayed decreased this parameter after 48 h. Furthermore, CYN was also demonstrated to exert damage at the synaptic level in a murine primary neuronal culture in a concentration- and time-dependent manner. These data highlight the importance of studying the neurotoxic properties of this cyanotoxin in different experimental models.

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Section: Discussionmentioning

confidence: 99%

Cytotoxicity and Effects on the Synapsis Induced by Pure Cylindrospermopsin in an E17 Embryonic Murine Primary Neuronal Culture in a Concentration- and Time-Dependent Manner

Hinojosa

Prieto

Muñoz-Castro

et al. 2022

Toxins

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“… Used to treat Flu, malaria, headaches, skin diseases, bronchitis, asthma, herpes simplex arthritis, liver problem, fevers, typhoid fever and inflammation. Used to treat meningitis in Ayurveda [ 27 , 224 , 225 ] Inhibited Epstein Barr Virus, foot and mouth disease virus, Newcastle disease virus, hepatitis B virus, herpes simplex virus, influenza virus A and HIV [ 226 , 227 ] Aqueous leaf extract did not cause mortality at 6400 mg/kg [225] Hepatitis, meningitis, smallpox, monkey pox, COVID-19, yellow fever, poliomyelitis Musa sapientum L. Used as a memory enhancer and to treat mental illness in west Africa, diarrhea, inflammation, eczema, burns, diabetes, cholera, dysentery and pain [ 228 , 229 ] Induced anti-yellow fever virus activity [40] The LD 50 for aqueous extract of unripe fruit is > 5000 mg/kg [230] Hepatitis, meningitis, lassa fever, poliomyelitis Nauclea diderrichii (De Wild.) Merr.…”

Section: Discussionmentioning

confidence: 99%

Traditional medicinal plants used for treating emerging and re-emerging viral diseases in northern Nigeria

Abubakar

Kankara

Malami

et al. 2022

European Journal of Integrative Medicine

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“…The pathophysiology of amyloidogenesis is strongly implicated in oxidative stress through a variety of mechanisms, including induction of protein oxidation, as well as nucleic acids and lipids, glycation end products formation, mitochondrial dysfunction, β-amyloid deposition, and plaque formation. Therefore, it is logical to assume that natural products with pronounced antioxidant effects might possess anti-amyloid and generally anti-neurodegenerative (neuroprotective) activity [ 66 , 67 , 68 ]. However, despite rather high antioxidant activity of both the fractions and isolated compounds, the aqueous and ethyl acetate fractions did not show any neuroprotective properties in the cell models of the Parkinson and Alzheimer diseases.…”

Section: Discussionmentioning

confidence: 99%

Phytochemical Characterization of Water Avens (Geum rivale L.) Extracts: Structure Assignment and Biological Activity of the Major Phenolic Constituents

Orlova

Kysil

Цветкова

et al. 2022

Plants

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Water avens (Geum rivale L.) is a common Rosaceae plant widely spread in Europe and North America. It is rich in biologically active natural products, some of which are promising as prospective pharmaceuticals. The extracts of water avens are well known for their triterpenoid metabolites and associated anti-inflammatory, antimicrobial and antioxidant activities. However, the polyphenolic profiles of G. rivale L. are still awaiting complete characterization. Accordingly, the contribution of its individual components to the antioxidant, antibacterial and neuroprotective activity of the extracts is still unknown. As this plant can be available on an industrial scale, a better knowledge of its properly-relevant constituents might give access to new highly-efficient pharmaceutical substances and functional products. Therefore, herein we comprehensively characterize the secondary metabolome of G. rivale by ESI-HR-MS, ESI-HR-MSn and NMR spectroscopy with a special emphasis on the polyphenolic composition of its aerial parts. Furthermore, a multilateral evaluation of the antioxidant, neuroprotective and antibacterial properties of the aqueous and ethyl acetate fractions of the total aqueous alcoholic extract as well as individual isolated polyphenols was accomplished. Altogether four phenolic acid derivatives (trigalloyl hexose, caffeoyl-hexoside malate, ellagic acid and ellagic acid pentoside), six flavonoids (three quercetin derivatives, kaempferol and three its derivatives and two isorhamnetin derivatives) and four tannins (HHDP-hexoside, proantocyanidin dimer, pedunculagin I and galloyl-bis-HHDP-hexose) were identified in this plant for the first time. The obtained aqueous and ethyl acetate fractions of the total extract as well as the isolated individual compounds showed pronounced antioxidant activity. In addition, a pronounced antibacterial activity against several strains was proved for the studied fractions (for ethyl acetate fraction the highest activity against E. coli АТСС 25922 and S. aureus strains ATCC 27853 and SG-511 (MIC 15.6 μg/mL) was observed; for aqueous fraction—against Staphylococcus aureus SG-511 (MIC 31.2 μg/mL)). However, the anti-neurodegenerative (neuroprotective) properties could not be found with the employed methods. However, the antibacterial activity of the fractions could not be associated with any of the isolated individual major phenolics (excepting 3-O-methylellagic acid). Thus, the aerial parts of water avens represent a promising source of polyphenolic compounds with antioxidant activity and therefrom derived human health benefits, although the single constituents isolated so far lack a dominant selectively bioactive constituent in the bioassays performed.

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Medicinal Plants for Anti-neurodegenerative diseases in West Africa

Cited by 27 publications

References 221 publications

Cytotoxicity and Effects on the Synapsis Induced by Pure Cylindrospermopsin in an E17 Embryonic Murine Primary Neuronal Culture in a Concentration- and Time-Dependent Manner

Cytotoxicity and Effects on the Synapsis Induced by Pure Cylindrospermopsin in an E17 Embryonic Murine Primary Neuronal Culture in a Concentration- and Time-Dependent Manner

Traditional medicinal plants used for treating emerging and re-emerging viral diseases in northern Nigeria

Phytochemical Characterization of Water Avens (Geum rivale L.) Extracts: Structure Assignment and Biological Activity of the Major Phenolic Constituents

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