Medicinal plants and their traditional uses in different locations

Miranda, Juan José Maldonado

doi:10.1016/b978-0-12-824109-7.00014-5

Cited by 25 publications

(15 citation statements)

References 26 publications

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“…Since creation, medicinal plants have occurred in nature, to serve medicinal and other purposes [19,20]. Most, if not all the drugs employed in the treatment of diseases have their origin directly or indirectly in natural products including plants [21,22].…”

Section: Resultsmentioning

confidence: 99%

“…More than two plants may be combined in ethnomedicine for malaria [10,19], but not all the combinations may be effective. Of all the combination ratios of EGA tested, three ratios, 1:2:2, 2:1:2 and 3:3:2 gave % chemo suppressions that were significantly (P =.00) higher than the negative control.…”

Section: In Vivo Antimalarial Activity Of the Combination Eugenia Gon...mentioning

confidence: 99%

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In vivo Chemosuppressive effects of Combinations of Three Nigerian Ethnomedicinal Antimalarial Plants

Odediran

Ehigie

Akadiri

et al. 2022

EJMP

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Aims: Appropriate ratios for combining some African ethnomedicinal plants with proven anti-plasmodial activity were determined with the aim of obtaining herbal remedies with higher efficacies. Place and Duration of the Study: Study was conducted in the Department of Pharmacognosy, Obafemi Awolowo University, Ile-Ife Nigeria. Study Design: Infusions of dried powders of three Nigerian ethnomedicinal plants, Eugenia uniflora leaf, Gongronema latifolium root and stem and Artocarpus altilis stem bark, were separately evaluated and in varied combination ratios for their anti-plasmodial activities Methodology: The infusions were separately prepared, concentrated in vacuo, freeze-dried and evaluated at 400mg/kg against Plasmodium berghei berghei parasites, using the Peter’s four-day chemosuppressive mice model. Normal saline and chloroquine (10mg/kg) were negative and positive controls, respectively. 2- and 3-combinations of the infusions were similarly tested. Results: Of the 2-plant combination ratios, 1:1, 1:3, 2:3 of EG and GA elicited percentage chemo suppressions which were comparable (P=.28; P=.07) to those of the single drugs. Only the EG ratios gave activities that were comparable (P=.28) to the positive control in addition to double survival times and high survivor values by EG 2:3 and GA 1:3. However, those of the EA group, gave relatively low values, barely above 20% with only the ratios 2:3 and 3:2 giving values which were significantly (P=.00) higher than negative control with double survival times. The 3-plant combination ratios, EGA 2:1:2 and 3:3:2 gave suppressions that were significantly (P=.00) higher than the negative control with others but comparable (P=.33) activities to those of the individual drugs. The other ratios with low suppression values were relatively inactive. But three ratios, EGA 3:1:2, 2:1:1, 1:1:1 elicited survival times doubled (204, 242 and 202 %) that of the negative control without commensurate high antiplasmodial activities. Conclusion: Ethnomedicinal antimalarial plants should not be combined without a data of previous scientific evaluations.

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Section: Resultsmentioning

confidence: 99%

Section: In Vivo Antimalarial Activity Of the Combination Eugenia Gon...mentioning

confidence: 99%

In vivo Chemosuppressive effects of Combinations of Three Nigerian Ethnomedicinal Antimalarial Plants

Odediran

Ehigie

Akadiri

et al. 2022

EJMP

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“…The treatment cost of diabetes is high due to the associated complications and medications used for its treatment have several side effects. Globally, medicinal plants are increasingly being utilized as an alternative treatment option [ 44 ], yet the primary challenge lies in the requirement for greater scientific backing. IP6 is present in almost all plant and mammalian cells as an organic phosphorus compound and is a reservoir of phosphorus in grains and oilseeds [ 45 ].…”

Section: Anti-diabetic Activity Of Ip6mentioning

confidence: 99%

Cellular and Molecular Activities of IP6 in Disease Prevention and Therapy

2023

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IP6 (phytic acid) is a naturally occurring compound in plant seeds and grains. It is a poly-phosphorylated inositol derivative that has been shown to exhibit many biological activities that accrue benefits in health and diseases (cancer, diabetes, renal lithiasis, cardiovascular diseases, etc.). IP6 has been shown to have several cellular and molecular activities associated with its potential role in disease prevention. These activities include anti-oxidant properties, chelation of metal ions, inhibition of inflammation, modulation of cell signaling pathways, and modulation of the activities of enzymes and hormones that are involved in carbohydrate and lipid metabolism. Studies have shown that IP6 has anti-oxidant properties and can scavenge free radicals known to cause cellular damage and contribute to the development of chronic diseases such as cancers and cardiovascular diseases, as well as diabetes mellitus. It has also been shown to possess anti-inflammatory properties that may modulate immune responses geared towards the prevention of inflammatory conditions. Moreover, IP6 exhibits anti-cancer properties through the induction of cell cycle arrest, promoting apoptosis and inhibiting cancer cell growth. Additionally, it has been shown to have anti-mutagenic properties, which reduce the risk of malignancies by preventing DNA damage and mutations. IP6 has also been reported to have a potential role in bone health. It inhibits bone resorption and promotes bone formation, which may help in the prevention of bone diseases such as osteoporosis. Overall, IP6’s cellular and molecular activities make it a promising candidate for disease prevention. As reported in many studies, its anti-inflammatory, anti-oxidant, and anti-cancer properties support its inclusion as a dietary supplement that may protect against the development of chronic diseases. However, further studies are needed to understand the mechanisms of action of this dynamic molecule and its derivatives and determine the optimal doses and appropriate delivery methods for effective therapeutic use.

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“…It serves multiple purposes, including the preservation of health, the prevention of ailments, the diagnosis of conditions, and the treatment of physical and mental illnesses [ 2 ]. Traditional medicine often employs natural resources, such as plants, animals, fungi, and even geological elements like rocks and minerals, regardless of whether their mechanisms are scientifically understood [ 3 ]. This approach is deeply entwined with indigenous beliefs, practical expertise, and ancestral wisdom passed down through generations [ 4 ].…”

Section: Introductionmentioning

confidence: 99%

A scoping review on the use of traditional medicine and oral health in Africa

Foláyan,

Olagunju,

Abodunrin

et al. 2024

PLoS ONE

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Background This review aimed to chart the landscape of literature concerning the precise applications of traditional medicine in managing specific oral diseases and, in doing so, to pinpoint knowledge gaps surrounding the use of traditional medicine for oral disease management in the African context. Methods A systematic search of the literature was conducted on PubMed, Web of Science, Scopus, and CINAHL. The search was conducted from the inception of the database till September 2023. A search of related citations and references was also carried out. Only English language publications were included. A summary of studies that met the inclusion criteria was conducted. Results Of the 584 records identified, 11 were duplicates and 12 studies, published between 2006 and 2021, met the inclusion criteria. The studies were published from eight countries located in the five sub-regions on the continent. All the studies were either experimental designs or ethnobotanical surveys and they all utilized plant-based remedies. The five experimental studies aimed to assess the impact of whole plants or plant extracts on the three microorganisms responsible for dental caries and seven responsible for periodontal diseases. The number of plant species identified by the seven ethnobotanical surveys ranged from 29 to 62 while the number of plan families ranged from 15 to 29. The remedies were either topical applied, use as mouth rinses, gargled, or chewed. The systemic routes of administration identified were inhalation and drinking. The remedies were used for the treatment of hard such as dental caries and tooth sensitivity, to soft tissue lesions such as mouth ulcers, gingival bleeding, and mouth thrush. Other oral disorders managed include halitosis, jaw fracture, and oral cancer. Conclusions Given the increasing prevalence of oral diseases within the region, the shortage of oral healthcare professionals and limited access to financial resources, it becomes imperative to support the generation of empirical evidence to enhance the provision of traditional medicine for oral healthcare in Africa.

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Medicinal plants and their traditional uses in different locations

Cited by 25 publications

References 26 publications

In vivo Chemosuppressive effects of Combinations of Three Nigerian Ethnomedicinal Antimalarial Plants

In vivo Chemosuppressive effects of Combinations of Three Nigerian Ethnomedicinal Antimalarial Plants

Cellular and Molecular Activities of IP6 in Disease Prevention and Therapy

A scoping review on the use of traditional medicine and oral health in Africa

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