Medicinal plants and secondary metabolites for diabetes mellitus control

Bahmani, Mahmoud; Golshahi, Hannaneh; Saki, Kourosh; Rafieian-Kopaei, Mahmoud; Delfan, Bahram; Mohammadi, Tahereh

doi:10.1016/s2222-1808(14)60708-8

Cited by 51 publications

(25 citation statements)

References 41 publications

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“…The result implied that the phenolics might contribute to antioxidant activity, however, less support on alpha-glucosidase inhibitory activities. It is considered that other secondary metabolites such as alkaloids and terpenes might play a role on alpha-glucosidase inhibitory activities as reported by previous study (Bahmani et al 2014). In addition, antagonistic or synergetic interactions between secondary metabolites may have contributed to the activity (Prihantini et al 2014;Bahmani et al 2014).…”

Section: Total Phenolic Contentmentioning

confidence: 88%

Antioxidant and alpha-glucosidase inhibitory activities of Euchresta horsfieldii

2019

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Abstract. Prihantini AI, Krisnawati, Setyayudi A. 2019. Antioxidant and alpha-glucosidase inhibitory activities of Euchresta horsfieldii. Biofarmasi J Nat Prod Biochem 17: 61-64. Euchresta horsfieldii, known as pranajiwa, is a medicinal plant that is widely grown in Bali and West Nusa Tenggara, Indonesia. Its seeds or fruits are commonly used for body freshness and stamina. The present study aimed to investigate the biological activities of leaves, root, stem, fruits, seeds of the E. horsfieldii. Antioxidant, alpha-glucosidase inhibitory activities and total phenolic compound were evaluated from methanolic extracts of all parts of E. horsfieldii. The result showed that leaf extract of E. horsfieldii exhibited the highest antioxidant activity with IC50 215.11±08.06 µg/mL. Meanwhile, the root extract had the highest alpha-glucosidase inhibitory activity and total phenolic compound with IC50 29.76±13.17 µg/mL and 763±0.01 mg GAE/100mg dry extract, respectively. In conclusion, the study suggested that E. horsfieldii is potential as natural source of antioxidant and alpha-glucosidase inhibitor agents.

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Section: Total Phenolic Contentmentioning

confidence: 88%

Antioxidant and alpha-glucosidase inhibitory activities of Euchresta horsfieldii

2019

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“…Phytochemical screening revealed the presence of alkaloids, cumarins, saponins, flavonoids and reducing sugars. The relationship between some of these compounds on glucose and lipid catabolism has been studied previously (Bahmani et al, 2014;Marrelli et al, 2016). The hypoglycemic ability has been described for alkaloids, e.g.…”

Section: Discussionmentioning

confidence: 99%

Hypoglycemic potential of Trixis angustifolia aqueous extract in alloxan-induced diabetic mice

Salazar-Gómez

Vargas-Dı́az

Garduño‐Siciliano

2019

Bangladesh J Pharmacol

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The aim of the present study was to evaluate the hypoglycemic potential of Trixis angustifolia in alloxan-induced diabetic mice. An intragastric administration of the aqueous extract (50, 100 and 200 mg/kg) prepared from the aerial parts of T. angustifolia was evaluated. The treatment with the extract at 100 mg/kg produced a significant lowered (30.5%) of the blood glucose levels in diabetic mice after 15 days of daily oral administration. In addition, the extract induced a significant decrease in serum total cholesterol, low density lipoprotein whereas increased the high-density lipoprotein level. Additionally, the presence of alkaloids, cumarins, saponins, flavonoids and reducing sugars were identified in the extract. These findings provide a basis explaining the traditional folk medicine use of this plant as a hypoglycemic agent by the Mexican people. Article Info

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“…α-glucosidase constitutes a family of enzymes hydrolase, located in the brush-border surface membrane of small intestinal cells, and it is the key enzyme by which the final step of digestion is catalyzed [24]. Hence, glucosidase inhibitors can stop the liberation of D-glucose from complex dietary carbohydrates and can delay the glucose absorption which in turn reduce blood glucose level and decrease hyperglycemia [25,26]. In this present study, in vitro α-amylase and α-glucosidase inhibitor activity of extracts and fractions of A. procera stem bark were evaluated.…”

Section: Discussionmentioning

confidence: 99%

In VITRO Α-Amylase AND Α-Glucosidase INHIBITOR ACTIVITIES OF ALBIZIA PROCERA STEM BARK

Anand

Sathish

2018

Asian J Pharm Clin Res

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Objective: This current study was carried out to determine the in vitro α-amylase and α-glucosidase inhibitory activity of extract and fractions of Albizia procera. Methods: The α-amylase and α-glucosidase inhibition assay was carried out at concentrations 50–2000 μg/ml and acarbose used as standard. The absorbance was measured at 540 nm and recorded by spectrophotometer. Percentage inhibition was calculated for both the assays. Preliminary phytochemical screening was also evaluated using standard procedures.Results: There was a dose-dependent percentage inhibition of extracts (petroleum ether and ethanol) and fractions (chloroform, ethyl acetate, and n-butanol). The ethanol extract and n-butanol fraction show good inhibitory activity against both α-amylase and α-glucosidase with the percentage inhibition of 86.20% and 88.20% and 83.13% and 87.10%, respectively. The preliminary phytochemical screening shows that ethanol extract consists of active constituents such as flavonoids and phenolic compounds and tannins.Conclusion: This finding suggests that the ethanol extract and n-butanol fraction show good inhibitory activity against both α-amylase and α-glucosidase and show good antidiabetic activity.

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Medicinal plants and secondary metabolites for diabetes mellitus control

Cited by 51 publications

References 41 publications

Antioxidant and alpha-glucosidase inhibitory activities of Euchresta horsfieldii

Antioxidant and alpha-glucosidase inhibitory activities of Euchresta horsfieldii

Hypoglycemic potential of Trixis angustifolia aqueous extract in alloxan-induced diabetic mice

In VITRO Α-Amylase AND Α-Glucosidase INHIBITOR ACTIVITIES OF ALBIZIA PROCERA STEM BARK

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