Medicinal Plant Extracts and Their Use As Wound Closure Inducing Agents

Medellín-Luna, Mitzzy Fátima; Castañeda-Delgado, Julio Enrique; Martínez-Balderas, V Yordani; Cervantes-Villagrana, Alberto R.

doi:10.1089/jmf.2018.0145

Cited by 15 publications

(14 citation statements)

References 87 publications

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“…The usage of natural derivatives for wound treatments, as alternatives to chemotherapy, attained great concerns to manage skin infections and promote its regeneration [34]. Pro-based formulations were proposed as effectual treatments to accelerate the natural reorganization of injured tissues, through augmenting keratinocyte proliferation [58].…”

Section: Resultsmentioning

confidence: 99%

“…Wound healing comprises complicated multistep processes affected with varied external and internal factors; skin injury is regularly accompanied by microbial infections and apparent inflammation [34]; these added aspects direct to further required therapies with an extended duration that include antimicrobial and anti-inflammatory agents. The misuse/overuse of antibiotics instigated the emergence of multiple resistant microbial pathogens that require innovative antimicrobial agent/compounds for their fighting [30].…”

Section: Introductionmentioning

confidence: 99%

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Formulation of Insect Chitosan Stabilized Silver Nanoparticles with Propolis Extract as Potent Antimicrobial and Wound Healing Composites

Al-Saggaf

2021

International Journal of Polymer Science

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Skin wounds are frequently influenced with microbial infections and inflammation, which need innovative agents for disputing them. Chitosan (Csn) was extracted from larvae of BSF “black soldier fly, Hermetia illucens” and ethanolic propolis extract (Pro) was employed for synthesizing silver nanoparticles (Ag-NPs), using facile biogenic protocol. The BSF-Csn was acquired with a yield of 1.56%, 91.3% deacetylation degree, and 88.600 Dalton molecular weight. The Ag-NPs were effectually biosynthesized using Pro, with a mean diameter of 8.73 nm and zeta potential of -21.34 mV. The antimicrobial activities assessment of insect Csn, Pro, synthesized Ag-NPs with Pro, and their composite against skin pathogens (Staphylococcus aureus and Candida albicans) revealed the elevated efficiency of the individual agents and the superior action of their composite (Csn/Pro/Ag-NPs), with 26.3 and 23.4 mm inhibition zones and inhibitory concentrations of 35.0 and 45.0 μg/mL from the composite toward S. aureus and C. albicans, respectively, which exceeded the actions of commercial antibiotics. The treatment of rat’s wounds with this composite promisingly led to faster healing of wounds and absence of inflammation and infection signs. The powerful actions of Csn/Pro/Ag-NPs as antimicrobial and wound healing composite strongly advocate their applications for skin protection, disinfection, and regeneration.

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Section: Resultsmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Formulation of Insect Chitosan Stabilized Silver Nanoparticles with Propolis Extract as Potent Antimicrobial and Wound Healing Composites

Al-Saggaf

2021

International Journal of Polymer Science

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“…The mechanism through which M. sylvestris exert its wound healing potential is not clearly established. However, it was suggested that M. sylvestris act on fibrosis‐free granulation tissue formation in skin (Medellin‐Luna, Castaneda‐Delgado, Martinez‐Balderas, & Cervantes‐Villagrana, ).…”

Section: Pharmacological Properties Of Malva Plantsmentioning

confidence: 99%

Malva species: Insights on its chemical composition towards pharmacological applications

Sharifi‐Rad

Melgar‐Lalanne

Hernández-Álvarez

et al. 2019

Phytotherapy Research

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Malvaceae family is typical from the Mediterranean region, contains 240 genera and more than 4,200 species. They are most commonly used as ornamental plants, although they can also be conceived as a food resource and remedy for various diseases, such as digestive, respiratory, genitourinary, throat infections, and skeletal and skin disorders, as also injuries where they are profoundly applied for skin care and as antiseptic and demulcent. They also possess diuretic, lenitive, spasmolytic, and laxative effects, besides to be used as antidiarrheal. Thus, the present review provides in‐depth data on Malva spp. potential applications and phytochemical composition for food and pharmaceutical industries. Habitat and cultivation conditions and the clinical reports related to its biological effects are also emphasized. Malva spp. possess a wide variety of chemical constituents (such as polysaccharides, coumarins, flavonoids, polyphenols, vitamins, terpenes, and tannins) found in different plant organs, especially in leaves and flowers, connected to their biological activity. In general, Malva spp. have rather moderate antimicrobial activity, high antiinflammatory and wound healing activities, strong antioxidant activity, and anticancer properties. Results from in vitro and in vivo experiments encourage more in‐depth studies, namely clinical trials, towards to improve knowledge on the use of Malva spp. for the treatment of various health conditions in humans.

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“…Some research has shown that the components of aloe vera-derived gels include polysaccharides, amino acids, tannins, and enzymes 57 . When these components are combined in vitro with aloe vera gel, they induce the proliferation of various cell lines, which results in faster healing times 57 . Aloe vera also strongly stimulates the proliferation and migration of fibroblasts and keratinocytes isolated from normal human neonatal foreskin in vitro 58 .…”

Section: Discussionmentioning

confidence: 99%

Second-Degree Burns and Aloe Vera: A Meta-analysis and Systematic Review

Sharma

Alfonso

Gordon

et al. 2022

Adv Skin Wound Care

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ObjectiveAloe vera is a cost-effective, accessible wound care adjunct with a minimal risk profile. Despite its centuries-long history being used to treat varying wound types, published reports remain inconclusive on its efficacy. In this article, the authors report the results of a systematic review assessing the efficacy of topical aloe vera products in wound care applications, as well as a meta-analysis of its utility in burn healing where data are most robust.Data SourcesIn accordance with PRISMA (Preferred Reporting Items for Systematic Reviews and Meta-Analyses) guidelines, the authors searched PubMed, EMBASE, and Cochrane CENTRAL for randomized controlled trials assessing the use of aloe vera in healing various wound types.Study SelectionThe database search identified 91 articles. After duplicates were removed, 74 articles were screened, and of those, 47 were assessed for eligibility. Ultimately, 28 articles were included in the qualitative synthesis, and 4 studies assessing second-degree burns were included in the meta-analysis.Data ExtractionThe following data points were collected from each study: number of participants/wounds, treatment type, adjunctive therapy (if any), and primary outcomes.Data SynthesisRisk-of-bias analysis was conducted on included articles, and results were compiled. A meta-analysis was undertaken for studies focusing on the treatment of burns. Cumulatively, these studies had a total of 133 patients with 163 wounds being assessed. Analysis revealed a statistically significant mean difference in time to healing of 4.44 days in favor of aloe vera treatment (P = .004).ConclusionsTopical aloe vera usage for second-degree burn wound healing demonstrated significantly faster time to healing compared with other treatments.

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Medicinal Plant Extracts and Their Use As Wound Closure Inducing Agents

Cited by 15 publications

References 87 publications

Formulation of Insect Chitosan Stabilized Silver Nanoparticles with Propolis Extract as Potent Antimicrobial and Wound Healing Composites

Formulation of Insect Chitosan Stabilized Silver Nanoparticles with Propolis Extract as Potent Antimicrobial and Wound Healing Composites

Malva species: Insights on its chemical composition towards pharmacological applications

Second-Degree Burns and Aloe Vera: A Meta-analysis and Systematic Review

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