Medicinal Flowers. XXXIII. Anti-hyperlipidemic and Anti-hyperglycemic Effects of Chakasaponins I–III and Structure of Chakasaponin IV from Flower Buds of Chinese Tea Plant (<i>Camellia sinensis</i>)

Abstract

Effects of principal saponins, chakasaponins I-III, from the flower buds of Camellia sinensis cultivated in Fujian province, China on plasma triglyceride (TG) and glucose levels in olive oil or sucrose-loaded mice were examined. Chakasaponins I-III at 50 and 100 mg/kg significantly inhibited increases in plasma TG and glucose levels. Furthermore, they prevented gastric emptying, suggesting that the former inhibitory effect is partly dependent on the inhibition of gastric emptying. In addition, the chemical structure of a new acylated oleanane-type triterpene oligoglycoside, chakasaponin IV, was elucidated on the basis of chemical and physicochemical evidence.

Medicinal Flowers. XXXX.¹⁾ Structures of Dihydroisocoumarin Glycosides and Inhibitory Effects on Aldose Reducatase from the Flowers of <i>Hydrangea macrophylla</i> var. <i>thunbergii</i>

“…[2][3][4][5][6] However, a full chemical analysis of the flowers from this plant has not yet been performed. In the course of our chemical and pharmacological studies on Hydrangea plants [2][3][4][5][6][7][8] and medicinal flowers, [9][10][11][12][13][14] we recently reported the isolation and structure elucidation of secoiridoid glycosides named hydrangeamines A and B with a pyridine ring from the flowers of H. macrophylla var. thunbergii cultivated in Nagano prefecture, Japan.…”

New biofunctional effects of the flower buds of Camellia sinensis and its bioactive acylated oleanane-type triterpene oligoglycosides

“…of Fuijian Chaka also inhibited plasma TG elevation in olive oil-loaded mice and plasma glucose elevation in sucrose-loaded mice [12]. Chakasaponins I ( 11 )–IV ( 14 ) isolated from Fujian Chaka, and their chemical structures were determined [12, 16].…”

“…of Fuijian Chaka also inhibited plasma TG elevation in olive oil-loaded mice and plasma glucose elevation in sucrose-loaded mice [12]. Chakasaponins I ( 11 )–IV ( 14 ) isolated from Fujian Chaka, and their chemical structures were determined [12, 16]. In addition, chakasaponins V ( 15 ) and VI ( 16 ) together with floratheasaponins A ( 1 )–I ( 9 ), chakasaponins I ( 11 )–III ( 13 ), and assamsaponin E ( 25 ) were isolated from the dried flower buds of C. sinensis cultivated in Sichuan province of China (Sichuan Chaka) [22].…”

“…Foliatheasaponins from the leaves of Japanese C. sinensis (Tencha) have also been reported to display such effects [10]. With regard to the biofunctions of the tea flower (‘Chaka’ in Japanese), we have reported the beneficial biofunctions of the extract for health promotion—antihyperlipidemic [11, 12], antihyperglycemic [12, 13], gastroprotective [13], and antiobesity effects [14] in vivo, with antiallergic [15], pancreatic lipase inhibitory [16], and amyroid β (Aβ) aggregation inhibitory effects [17]. …”

Medicinal Flowers. XXXVIII. Structures of Acylated Sucroses and Inhibitory Effects of Constituents on Aldose Reducatase from the Flower Buds of Prunus mume

“…In the course of our studies on bioactive constituents from medicinal flower, [2][3][4][5][6] we previously reported the isolation and structure elucidation of acylated sucroses named prunoses I (11), II (12), and III (13) with inhibitory effects on platelet aggregation and aldose reductase and radical scavenging effect from the flower buds of Prunus (P.) mume Sieb. et Zucc.…”