Medicinal effects of Peruvian maca (<i>Lepidium meyenii</i>): a review

Peres, Natália da Silva Leitão; Bortoluzzi, Leticia Cabrera Parra; Marques, Leila Larisa Medeiros; Formigoni, Maysa; Fuchs, Renata Hernandez Barros; Droval, Adriana Aparecida; Cardoso, Flávia Aparecida Reitz

doi:10.1039/c9fo02732g

Cited by 69 publications

(52 citation statements)

References 49 publications

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“…Antimicrobial agents with repurposing potential against viral diseases, such as teicoplanin, ivermectin, itraconazole, and nitazoxanide, have been described [35]. Considering this, compounds isolated from Smallanthus sonchifolius (commonly called Yacon), a plant of the family Asteraceae, native to the Andean regions, that has been studied against colon cancer, diabetes, and obesity [36], and Lepidium meyenii (commonly called Maca), a root native to the Andean region, that has shown neuroprotective effects, antidepressant, antioxidant, anticancer, and anti-inflammatory activities [37] were searched in the Pub-Chem, Drug-Bank and ChEMBL databanks. In this regard, it was possible to find 14 and 26 compounds described from S. sonchilofolius (Table 1) and L. meyenii (Table 2), respectively.…”

Section: Literature Searchmentioning

confidence: 99%

Antiviral Activity of Metabolites from Peruvian Plants against SARS-CoV-2: An In Silico Approach

et al. 2021

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(1) Background: The COVID-19 pandemic lacks treatments; for this reason, the search for potential compounds against therapeutic targets is still necessary. Bioinformatics tools have allowed the rapid in silico screening of possible new metabolite candidates from natural resources or repurposing known ones. Thus, in this work, we aimed to select phytochemical candidates from Peruvian plants with antiviral potential against three therapeutical targets of SARS-CoV-2. (2) Methods: We applied in silico technics, such as virtual screening, molecular docking, molecular dynamics simulation, and MM/GBSA estimation. (3) Results: Rutin, a compound present in Peruvian native plants, showed affinity against three targets of SARS-CoV-2. The molecular dynamics simulation demonstrated the high stability of receptor–ligand systems during the time of the simulation. Our results showed that the Mpro-Rutin system exhibited higher binding free energy than PLpro-Rutin and N-Rutin systems through MM/GBSA analysis. (4) Conclusions: Our study provides insight on natural metabolites from Peruvian plants with therapeutical potential. We found Rutin as a potential candidate with multiple pharmacological properties against SARS-CoV-2.

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Section: Literature Searchmentioning

confidence: 99%

Antiviral Activity of Metabolites from Peruvian Plants against SARS-CoV-2: An In Silico Approach

et al. 2021

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“…It has been used in traditional folk medicine for generations to cure physical issues including anaemia, fertility, hormone imbalances, and menopausal symptoms like decreased sex desire, mood swings, and vaginal dryness. 83 A small number of studies have found that maca is more effective than a placebo at increasing sex desire and reducing psychological symptoms like anxiety and despair. Although no serious side effects have indeed been reported, there is a scarcity of safety information.…”

Section: Lepidium Meyenii (Maca)mentioning

confidence: 99%

Promising Herbs as Alternatives for Women with Symptoms of Menopause: A Review

Manipriya¹,

Mallika²,

Dixit³

et al. 2021

JDVAT

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Hot flashes, sleep issues, bipolar disorder, decreased libido, weight gain, and impairments in cognitive performance are all common symptoms of menopause. Herbs and alternative therapies are often of great value to people in the management and treatment of the signs and complications of menopause, due to the adverse effects of hormone therapy. The practices and effects of medicinal plants used in the management of menopausal symptoms are thoroughly reviewed in this article. Clinical investigations have recently demonstrated the efficacy of using many plants and herbs to alleviate menopausal symptoms. Some herbs' traditional uses also have been noted. Medicinal herbs have the potential to exhibit an important role in the treatment of menopausal symptoms; however, further research is needed to back up their efficacy in this domain.

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“…This interest has established Maca as one of the flagship products of Peru, being sold as powder, pills, capsules, flour, liquor, and extracts at a variety of retail outlets such as health food stores and smoothie shops. 1 The Maca root, native to the Peruvian Andean region is botanically a member of the Brassicaceae family, growing in high altitude region, characterized by extreme weather conditions as rocky formations, intense sunlight and strong winds. [2][3][4][5][6] There are diverse varieties according to the color of the hypocotyl, and many Maca root-based food supplements of different colors are available on the world market due to the possible effect on the treatment of a wide range of diseases and medical disorders.…”

Section: Introductionmentioning

confidence: 99%

Antidepressant-Like Behavioral and Spatial Memory Effects in Peruvian Red Maca (Lepidium meyenii)-Treated Rats

Ybañez-Julca¹,

Quispe-Díaz²,

Asunción-Alvarez³

et al. 2021

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The hypocotyls of Lepidium meyenii (Red Maca) were collected in September 2018 in the district of Carhuamayo, Province of Junin at 4000 m above sea level, in the Valle Mantaro, Peru. Once collected, the specimen was identified from the "Herbarium Truxillense de la Facultad de Ciencias Biológicas de ABSTRACT Introduction: Lepidium meyenii, known with the vernacular name of "Maca" , is a Brassicaceae family that has been widely used by Peruvian traditional medicine in cases of sexual dysfunction, memory loss, and several other diseases and pathologies. Objetive: The aim of the study was to test the potential effects of aqueous extract of Red Maca (AQ-RM) on antidepressant-like behavioral in male rats and spatial memory in ovariectomized (OVX) rats. Methods: Forced swimming test was used to examine the potential antidepressant AQ-RM activity in male rats. Fluoxetine and amitryptiline were included as reference drugs. Morris Water Maze test was employed to examine the effect of AQ-RM on spatial memory in ovariectomized (OVX) rats. Such effects were compared to exogenous estradiol administration. The potential role of oxidative stress on spatial memory loss was assessed by measuring malondialdehyde (MDA) levels in rats brain homogenates. Results: AQ-RM enhances swimming and climbing activities while reducing the time of immobility in male rats. Meanwhile, it prevents the decrease in the time spent in the target quadrant and displays higher values in the number of crossings in OVX-rats as compared to OVX-control rats. MDA levels in brain homogenates were decreased in OVX-rats receiving AQ-RM. Conclusion: Oral administration of AQ-RM has anti-depressive application in male rats; and increases the ability of learning and memory in OVX rats.

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Medicinal effects of Peruvian maca (Lepidium meyenii): a review

Abstract: Peruvian maca (Lepidium meyenii) is a root native to the Andean region, cultivated for at least 2000 years.

Cited by 69 publications

References 49 publications

Antiviral Activity of Metabolites from Peruvian Plants against SARS-CoV-2: An In Silico Approach

Antiviral Activity of Metabolites from Peruvian Plants against SARS-CoV-2: An In Silico Approach

Promising Herbs as Alternatives for Women with Symptoms of Menopause: A Review

Antidepressant-Like Behavioral and Spatial Memory Effects in Peruvian Red Maca (Lepidium meyenii)-Treated Rats

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