Medicinal Chemistry as a Conduit for the Modulation of Quorum Sensing

Lowery, Colin A.; Salzameda, Nicholas T.; Sawada, Daisuke; Kaufmann, Gunnar F.; Janda, Kim D.

doi:10.1021/jm901742e

Cited by 57 publications

(41 citation statements)

References 153 publications

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“…In a series of enzymatic reactions catalyzed by LuxS enzyme, boron and cyclic form of 4, 5-dihydroxy 2,3 pentanedione (DPD) react to form AI-2 (50). The role of boron in AI-2 signal and its involvement in quorum sensing system has been reported by further studies (52,53). Additionally, the increased production and activity of AI-2 via addition of boric acid were also reported (54).…”

Section: Effect Of Boric Acidmentioning

confidence: 95%

Effective stimulating factors for microbial levan production by Halomonas smyrnensis AAD6T

Sarılmışer

Ateş

Ozdemir

et al. 2015

Journal of Bioscience and Bioengineering

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Section: Effect Of Boric Acidmentioning

confidence: 95%

Effective stimulating factors for microbial levan production by Halomonas smyrnensis AAD6T

Sarılmışer

Ateş

Ozdemir

et al. 2015

Journal of Bioscience and Bioengineering

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“…AI-2 refers to a class of furanosyl borate diesters ( 17 ) derived from cyclization of 4,5-dihydroxy-2,3-pentanedione (DPD, 18 ). 63 The DPD precursor ( 18 ) can result in different structures or stereoisomers of 17 depending on the species producing it, giving the AI-2 class some level of specificity despite being widely produced and recognized by many different bacterial phyla. Overall, however, 17 is considered to mediate interspecies microbial chemical communication because of the ubiquity of the 18 synthase.…”

Section: Dysbiosis and Homeostasismentioning

confidence: 99%

Calling All Hosts: Bacterial Communication In Situ

Cleary

Condren

Zink

et al. 2017

Chem

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Bacteria are cosmopolitan organisms that in recent years have demonstrated many roles in maintaining host equilibrium. In this review, we discuss three roles bacteria can occupy in a host: pathogenic, symbiotic, and transient, with a specific focus on how bacterial small molecules contribute to homeostasis or dysbiosis. First, we will dissect how small molecules produced by pathogenic bacteria can be used as a source for communication during colonization and as protection against host immune responses. The ability to achieve a higher level of organization through small molecule communication gives pathogenic bacteria an opportunity for increased virulence and fitness. Conversely, in symbiotic relationships with hosts, small molecules are used in the initial acquisition, colonization, and maintenance of this beneficial population. Chemical signals can come from both the host and symbiont, and it is often observed that these interKingdom symbioses result in coevolution of both species involved. Furthermore, the transition from transient to commensal or opportunistic likely relies on molecular mechanisms. The small molecules utilized and produced by transient bacteria are desirable for both the immune and nutritional benefits they provide to the host. Finally, the advantages and disadvantages of modern analytical techniques that are available to researchers in order to study small molecules in situ is an important aspect of this review. It is our opinion that small molecules produced by bacteria are central to many biological processes and a larger focus on uncovering the function and identity of these small molecules is required to gain a deeper understanding of host-microbe associations.

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“…Several quorum sensing blocking strategies are directed to looking for inhibition of the synthase enzyme responsible for the production of the signaling molecule or receptor protein; inhibition of the chemical signal mediated by OHHL; or inhibition of the receptor protein that modulates quorum sensing [75,76]. In this way enzyme and receptorcoupled high-throughput cell-free screen have been developed for find inhibitors of intercellular quorum-sensing signals as quorum sensing inhibitors approach [77].…”

Section: Quorum Sensingmentioning

confidence: 99%

Anti-Biofilm Drug Susceptibility Testing Methods: Looking for New Strategies against Resistance Mechanism

Bueno¹

2011

JMBT

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Biofilm is a reservoir of drug resistant microorganisms that can increase the failure rate of anti-infective therapy and is a public health concern. Antibiofilm drug discovery is necessary for developing new drugs, biocides and wound management protocols. This makes the standardization and implementation of in vitro antibiofilm screening platforms a challenge in the search for new antibiotics, because current antimicrobials are active against planktonic bacteria and have poor diffusion across biofilm matrix. Usually, based in the research topic, the antibiofilm methods have been classified in static and flow depending of continuous supply of nutrients that affect the microbial growth, the final aim of these assays is obtain Minimal Biofilm Inhibitory Concentration (MBIC) and Minimal Biofilm Eradication Concentration (MBEC) values as efficacy parameter of the compound or procedure evaluated, but is very important correlates data from different models in order to give real results of activity. This review aims at describing the initial tools for to establishing an antibiofilm drug discovery-prospecting program.

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Medicinal Chemistry as a Conduit for the Modulation of Quorum Sensing

Cited by 57 publications

References 153 publications

Effective stimulating factors for microbial levan production by Halomonas smyrnensis AAD6T

Effective stimulating factors for microbial levan production by Halomonas smyrnensis AAD6T

Calling All Hosts: Bacterial Communication In Situ

Anti-Biofilm Drug Susceptibility Testing Methods: Looking for New Strategies against Resistance Mechanism

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