Medication regularity of pulmonary fibrosis treatment by contemporary traditional Chinese medicine experts based on data mining

Zhang, Suxian; Wu, Hao; Liu, Jie; Gu, Hui-Hui; Li, Xiujuan; Zhang, Tiansong

doi:10.21037/jtd.2018.03.11

Cited by 20 publications

(19 citation statements)

References 9 publications

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“…The data on the use of traditional Chinese medicine in treating pulmonary diseases show that Activating Blood Circulation Chinese Medicine such as Salvia miltiorrhiza , Angelicae sinensis , Nourishing Qi such as Astragalus membranaceus and their combination have the highest frequency of clinical use (Du & Wang, ; Yan, Yan, Zeng, Li, & Huang, ; Zhang, Wu, Liu, Li, & Zhang, ). From 1999 to 2011, the results of investigation of the utilization of blood‐activating and stasis‐removing drugs for treating lung diseases showed that Salvia miltiorrhiza and peach kernels were most frequently used in the clinic, with the frequency reaching 16.36 and 16.14% (Chen, ), respectively.…”

Section: Introductionmentioning

confidence: 99%

Pharmacokinetics of salvianolic acid B, rosmarinic acid and Danshensu in rat after pulmonary administration of Salvia miltiorrhiza polyphenolic acid solution

Lü

Xing

Xue

et al. 2019

Biomedical Chromatography

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A sensitive and accurate LC-MS/MS method was established for quantifying salvianolic acid B (Sal B), rosmarinic acid (Ros A) and Danshensu (DA) in rat plasma. Salvia miltiorrhiza polyphenolic acid (SMPA), active water-soluble ingredients isolated and purified from Salvia miltiorrhiza Bge included Sal B, Ros A and DA. The pharmacokinetic analysis of Sal B, Ros A and DA after pulmonary administration of SMPA solution to rat was performed by LC-MS/MS. Results from the pharmacokinetic studies showed that the peak concentration of DA was 21.85 ± 6.43 and 65.39 ± 3.83 ng/ mL after pulmonary and intravenous administration, respectively. DA was not detected at 2 h after administration. The absolute bioavailabilities of Sal B and Ros A were respectively 50.37 ± 27.04 and 89.63 ± 12.16% after pulmonary administration of 10 mg/kg SMPA solution in rats. The absolute bioavailability of Sal B increased at least 10-fold after pulmonary administration, compared with oral administration. It was concluded that the newly established LC-MS/MS method was suitable for describing the pharmacokinetic characteristics of Sal B, Ros A and DA in rat after pulmonary administration of SMPA solution. The data from this study will provide a preclinical insight into the feasibility of pulmonary administration of SMPA. KEYWORDS LC-MS/MS, pharmacokinetics, pulmonary administration, Salvia miltiorrhiza polyphenolic acid

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Section: Introductionmentioning

confidence: 99%

Pharmacokinetics of salvianolic acid B, rosmarinic acid and Danshensu in rat after pulmonary administration of Salvia miltiorrhiza polyphenolic acid solution

Lü

Xing

Xue

et al. 2019

Biomedical Chromatography

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“…In the past decades, many efforts have been done to study this process, whereas most researches have only focused on one part of this process. Zhang et al [ 9 ] applied the data mining technology to explore the drug rules of pulmonary fibrosis based on TCM medical records. Yu et al [ 10 ] analyzed the dose data of TCM prescriptions by optimizing the traditional Cheng-Church double clustering algorithm (CC).…”

Section: Introductionmentioning

confidence: 99%

Research of insomnia on traditional Chinese medicine diagnosis and treatment based on machine learning

Tang

Yang

et al. 2021

Chin Med

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Background Insomnia as one of the dominant diseases of traditional Chinese medicine (TCM) has been extensively studied in recent years. To explore the novel approaches of research on TCM diagnosis and treatment, this paper presents a strategy for the research of insomnia based on machine learning. Methods First of all, 654 insomnia cases have been collected from an experienced doctor of TCM as sample data. Secondly, in the light of the characteristics of TCM diagnosis and treatment, the contents of research samples have been divided into four parts: the basic information, the four diagnostic methods, the treatment based on syndrome differentiation and the main prescription. And then, these four parts have been analyzed by three analysis methods, including frequency analysis, association rules and hierarchical cluster analysis. Finally, a comprehensive study of the whole four parts has been conducted by random forest. Results Researches of the above four parts revealed some essential connections. Simultaneously, based on the algorithm model established by the random forest, the accuracy of predicting the main prescription by the combinations of the four diagnostic methods and the treatment based on syndrome differentiation was 0.85. Furthermore, having been extracted features through applying the random forest, the syndrome differentiation of five zang-organs was proven to be the most significant parameter of the TCM diagnosis and treatment. Conclusions The results indicate that the machine learning methods are worthy of being adopted to study the dominant diseases of TCM for exploring the crucial rules of the diagnosis and treatment.

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“…[ 25 ] Due to the diversity of active ingredients in CHF compositions and the potential synergistic effect among them, which enable them to have a wide-ranging targets and multiple therapeutic mechanisms. [ 26 ] Moreover, acupuncture, moxibustion, and acupoint application also have the functions of regulating and improving inflammation and immunity. [ 27 – 29 ]…”

Section: Introductionmentioning

confidence: 99%

“…Many trials have shown that these TCM interventions seem to have positive significance for IPF treatment, especially for the improvement of symptoms and QoL. [ 26 ] Subsequently, the number of SRs and meta-analyses pooling these results increased significantly. [ 30 – 32 ] Currently, there is still no overview of systematic review (OoSR) to synthesize the evidences of effectiveness of multiple TCM interventions, either alone or combined with routine western medicine measures, on the main symptoms and QoL of IPF patients in these SRs.…”

Section: Introductionmentioning

confidence: 99%

Multiple Traditional Chinese Medicine interventions for idiopathic pulmonary fibrosis

et al. 2020

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Background: The therapeutic strategies of idiopathic pulmonary fibrosis (IPF) tend to be comprehensive. Improving the major symptoms and quality of life (QoL) is as important as postponing the process of fibrosis. However, only pirfenidone and nintedanib conditionally recommended by guidelines and no definite proof indicate that they can significantly ameliorate the main symptoms and QoL of IPF sufferers. At present, multiple types of Traditional Chinese Medicine (TCM) interventions alone or in combination with conventional western medicine managements are widespreadly applied in IPF treatment, which seemingly have a promising clinical effect, especially in ameliorating the main symptoms and improving QoL. Subsequently, the number of relevant studies in systematic reviews(SRs) and meta-analyses of randomized controlled trials(RCTs) increased significantly. Hence, we plan to implement an overview to collect, evaluate, and summarize the results of these SRs. Methods: An all-round literature retrieval will be conducted in 9 electronic databases, including PubMed, EMBASE, CINAHL, Cochrane Library, Epistemonikos, CNKI, CBM, Wanfang, and VIP. We will focus on the systematic review and meta-analysis of RCTs for multiple TCM interventions alone or in combination with routine western medicine measures in IPF treatment. The main outcomes we follow with interest include the improvement of major symptoms (cough, dyspnea) and QoL. Secondary outcomes will consist of minor symptoms improvement, clinical total effective rate, lung function, blood gas analysis, 6-minute walk text, adverse events, acute exacerbation, all-cause mortality, and IPF-related mortality. Two reviewers will independently select the SRs satisfactory with the enrolling criteria, extract key characteristics, and datas on predefined form, evaluate methodological quality by AMSTAR-2, ROBIS and PRISMA tools, and the quality of evidences adopting GRADE method. In case of any divergence will be reached an agreement by discussion or adjudicated by a third senior reviewer. We will perform a narrative synthesis of the proofs from SRs included. Results: The findings of this overvew will be presented at relevant conferences and submitted for peer-review publication. Conclusions: We expect to obtain comprehensive and reliable evidence of IPF treated by diversified TCM interventions from the potential standard SRs, which may provide suggestions for future RCTs and SRs. Registration number: INPLASY 202080110

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Medication regularity of pulmonary fibrosis treatment by contemporary traditional Chinese medicine experts based on data mining

Cited by 20 publications

References 9 publications

Pharmacokinetics of salvianolic acid B, rosmarinic acid and Danshensu in rat after pulmonary administration of Salvia miltiorrhiza polyphenolic acid solution

Pharmacokinetics of salvianolic acid B, rosmarinic acid and Danshensu in rat after pulmonary administration of Salvia miltiorrhiza polyphenolic acid solution

Research of insomnia on traditional Chinese medicine diagnosis and treatment based on machine learning

Multiple Traditional Chinese Medicine interventions for idiopathic pulmonary fibrosis

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