Pharmacokinetics of salvianolic acid B, rosmarinic acid and Danshensu in rat after pulmonary administration of <i>Salvia miltiorrhiza</i> polyphenolic acid solution

Lü, Peng; Xing, Yue; Xue, Zhifeng; Ma, Zhe; Zhang, Bin; Peng, Hong-Li; Zhou, Qi Tony; Liu, Hongfei; Liu, Zhidong; Li, Jiawei

doi:10.1002/bmc.4561

Cited by 25 publications

(15 citation statements)

References 46 publications

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“…RA could be rapidly eliminated from rat plasma collected at 4 and 8 h after the intravenous and oral administration, with elimination half-lives (t 1/2 ) of 0.67 ± 0.24 and 1.34 ± 0.22 h, respectively. Compared with previous reports (Lu et al, 2019;Yang et al, 2018) which targeted the in vivo process of TCM preparation or herbal extract, some of the pharmacokinetic parameters of RA determined were different to some extent, such as t 1/2 and t max . On the one hand, TCM preparations can affect the release and dissolution rate of small molecule compounds in the gastrointestinal tract, and on the other hand, drug-drug interactions may occur when RA and other components are intravenously or orally administrated together.…”

Section: Pharmacokinetics Studycontrasting

confidence: 76%

Rapid determination of rosmarinic acid and its two bioactive metabolites in the plasma of rats by LC–MS/MS and application to a pharmacokinetics study

Wang

Yue

et al. 2020

Biomedical Chromatography

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Rosmarinic acid (RA), an ester compound of caffeic acid (CA) and 3,4‐dihydroxyphenyllacic acid, is widely distributed in the herbs of the Lamiaceae family and has shown a wide spectrum of pharmacological properties. CA and FA (ferulic acid) are two bioactive metabolites in vivo after oral administration of RA; however, a rapid and robust analytical approach that can enable the quantitative assay of RA and two bioactive metabolites is still lacking. A liquid chromatography/tandem mass spectrometry method was established that was capable of the quantitative determination of RA, CA and FA by negative‐mode multiple reaction monitoring within 7 min using a Zorbax SB‐C18 column and an isocratic elution. This assay method was validated as linear over the investigated ranges with correlation coefficients (r) > 0.9950. The intra‐ and inter‐day precision was <10.65%, and the accuracies (relative error, %) <−6.41%. The validated approach was applied to a pharmacokinetics study of RA and its two metabolites in rats after oral and intravenous administration. RA was rapidly metabolized in both administration modes, whilst the metabolites CA and FA were only detectable by oral administration. The absolute availability of RA was calculated to be 4.13%.

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Section: Pharmacokinetics Studycontrasting

confidence: 76%

Rapid determination of rosmarinic acid and its two bioactive metabolites in the plasma of rats by LC–MS/MS and application to a pharmacokinetics study

Wang

Yue

et al. 2020

Biomedical Chromatography

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“…As above-mentioned, RA often serves as an indicator for the quality evaluation of some folk herbal medicines or compound medicines. In the same way, RA also acts as a representative component in the pharmacokinetic studies of these medicines such as the Salvia miltiorrhiza polyphenolic acid solution [ 286 ], Prunella vulgaris extract [ 287 ], ZibuPiyin Recipe [ 288 ], and Xuebijing Injection [ 289 ]. Table 2 presents the specific parameters of these pharmacokinetic studies including the AUC (0 → ∞) , T max , C max , and CL.…”

Section: Pharmacokineticsmentioning

confidence: 99%

A Comprehensive Review of Rosmarinic Acid: From Phytochemistry to Pharmacology and Its New Insight

et al. 2022

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Polyphenolic acids are the widely occurring natural products in almost each herbal plant, among which rosmarinic acid (RA, C18H16O8) is well-known, and is present in over 160 species belonging to many families, especially the Lamiaceae. Aside from this herbal ingredient, dozens of its natural derivatives have also been isolated and characterized from many natural plants. In recent years, with the increasing focus on the natural products as alternative treatments, a large number of pharmacological studies have been carried out to demonstrate the various biological activities of RA such as anti-inflammation, anti-oxidation, anti-diabetes, anti-virus, anti-tumor, neuroprotection, hepatoprotection, etc. In addition, investigations concerning its biosynthesis, extraction, analysis, clinical applications, and pharmacokinetics have also been performed. Although many achievements have been made in various research aspects, there still exist some problems or issues to be answered, especially its toxicity and bioavailability. Thus, we hope that in the case of natural products, the present review can not only provide a comprehensive understanding on RA covering its miscellaneous research fields, but also highlight some of the present issues and future perspectives worth investigating later, in order to help us utilize this polyphenolic acid more efficiently, widely, and safely.

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“…Macrophages profoundly altered the balance between destructive tissue remodeling and reparative tissue healing through their role in both promotion and resolution of the inflammatory response (Dale et al, 2016). NF‐κB signaling pathway is mainly composed of a series of NF‐κB/Rel proteins, including NF‐κB1, NF‐κB2, p50, p52, c‐Rel, Rel A (p65) and Rel B (P. Lu et al, 2019). Some studies reported that NF‐κB inhibitor markedly suppressed the activity of MMP‐2, MMP‐99, MMP‐3 and MMP‐12, and inhibited AAA formation (Shiraya et al, 2006).…”

Section: Discussionmentioning

confidence: 99%

Eugenol restrains abdominal aortic aneurysm progression with down‐regulations on NF‐κB and COX‐2

Zhai

Zhang

Ding

et al. 2022

Phytotherapy Research

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Abdominal aortic aneurysm (AAA) is a lethal disease without available medicine for treatment. This study aimed to evaluate the efficiency of eugenol (4-allyl-2-methoxyphenol) against AAA and the underlying mechanism. Eugenol is the major bioactive component of clove. A mouse AAA model was established through porcine pancreatic elastase (PPE) incubation peri-adventitially and 1% 3-aminopropanonitrile (BAPN) diet. Continuous AAA progression from day 0 to day 15 was observed after PPE plus BAPN treatment, according to the AAA diameter and histopathological evaluation. Accompanying with AAA progression, sustained increased expressions of CD68, COX-2 and NF-κB were observed through immunofluorescence assay. After elucidation the efficiency of eugenol against AAA progression by AAA diameter, hematoxylin-eosin staining and orcein staining, the down-regulations of eugenol on COX-2 and NF-κB were further detected by immunohistochemistry and western blot. Eugenol not only blocked AAA expansion and protected the integrity of aortic structure in a dose-dependent manner, but also held high oral bioavailability. Excellent efficiency, high oral bioavailability and down-regulation on COX-2/NF-κB endowed eugenol great potential for future AAA therapy.

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Pharmacokinetics of salvianolic acid B, rosmarinic acid and Danshensu in rat after pulmonary administration of Salvia miltiorrhiza polyphenolic acid solution

Cited by 25 publications

References 46 publications

Rapid determination of rosmarinic acid and its two bioactive metabolites in the plasma of rats by LC–MS/MS and application to a pharmacokinetics study

Rapid determination of rosmarinic acid and its two bioactive metabolites in the plasma of rats by LC–MS/MS and application to a pharmacokinetics study

A Comprehensive Review of Rosmarinic Acid: From Phytochemistry to Pharmacology and Its New Insight

Eugenol restrains abdominal aortic aneurysm progression with down‐regulations on NF‐κB and COX‐2

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