Medication errors with antituberculosis therapy in an inpatient, academic setting: forgotten but not gone

Jen, Shin-Pung; Zucker, Jason; Buczynski, Patrick; Odenigbo, CU; Cennimo, David; Patrawalla, Amee

doi:10.1111/jcpt.12347

Cited by 3 publications

(5 citation statements)

References 7 publications

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“…Frequently, these patients need hospitalization and to be referred to other health professionals. Previous studies have described DTP or medication errors identified by pharmacists and their intervention for patients with TB ( 10 – 12 ) or HIV/AIDS. ( 13 – 15 ) As far as we aware of, this is one of the first studies to assess DTP in patients coinfected with TB and HIV/AIDS.…”

Section: Discussionmentioning

confidence: 99%

“…Pharmacists, as members of the multiprofessional care team of coinfected patients, contribute to the assessment of aspects related to medication dose, drug interactions, omission and inadequate continuity of therapy, optimizing clinical outcomes. ( 10 – 11 )…”

Section: Discussionmentioning

confidence: 99%

“…Frequentemente, esses pacientes necessitam de internação e encaminhamento a outros profissionais de saúde. Estudos prévios descreveram PRM ou erros de medicação identificados por farmacêuticos e suas intervenções em pacientes com TB ( 10 – 12 ) ou HIV/AIDS. ( 13 – 15 ) Do nosso conhecimento, este é um dos primeiros estudos a avaliar PRM em pacientes coinfectados com TB e HIV/AIDS.…”

Section: Discussionunclassified

“…Os farmacêuticos, como membros da equipe multiprofissional de cuidado aos pacientes coinfectados, contribuem para a avaliação dos aspectos relacionados à dose dos medicamentos, interações medicamentosas, omissão e continuidade inadequada da terapia, otimizando os resultados clínicos. ( 10 – 11 )…”

Section: Discussionunclassified

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Drug therapy problems for patients with tuberculosis and HIV/AIDS at a reference hospital

Resende¹,

Miranda²,

Ceccato³

et al. 2019

Einstein (São Paulo)

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Objective: To determine the frequency of drug therapy problem in the treatment of patients with tuberculosis and HIV/AIDS. Methods: Data were obtained through a cross-sectional study conducted between September 2015 and December 2016 at a reference hospital in infectious diseases in Belo Horizonte (MG), Brazil. Sociodemographic, clinical, behavioral and pharmacotherapeutic variables were evaluated through a semi-structured questionnaire. Drug-related problems of pharmaceutical care were classified using the Pharmacotherapy Workup method. Factors associated with indication, effectiveness, safety and compliance drug therapy problem were assessed through multiple logistic regression. Results: We evaluated 81 patients, and 80% presented at least one drug therapy problem, with indication and adherence drug therapy problem being the most frequent. The factors associated with drug therapy problem were age, marital status, new case, ethnicity, time of HIV diagnosis and time to treat tuberculosis. Conclusion: The frequency of drug therapy problem in coinfected patients was high and the identification of the main drug therapy problem and associated factors may lead the multiprofessional health team to ensure the use of the most indicated, effective, safe and convenient medicines for the patients clinical condition. Tuberculosis and HIV/AIDS coinfected individuals aged over 40 years are more likely to have drug therapy problems during treatment; in that, the most frequente are those that signal toward need of medication for an untreated health condition and non-compliance to treatment. Thus, older patients, unmarried or married, who have treated tuberculosis before, with a shorter time to tuberculosis treatment and longer time to diagnose HIV/AIDS, should receive special attention and be better followed by a multiprofessional health team because they indicate a higher chance of presenting Problems related to the use of non-adherent drugs.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Section: Discussionunclassified

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Drug therapy problems for patients with tuberculosis and HIV/AIDS at a reference hospital

Resende¹,

Miranda²,

Ceccato³

et al. 2019

Einstein (São Paulo)

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“…Wrong medication and incomplete course for TB lead to MDR-TB, in India and it is very common. In the year Dec 2014 Buczynski et al 2 , and Feb 2016 Jen et al 3 , had reported that 58% and (44/72, 61%) of patients respectively were having at least one type of error. The most common type of error was associated with doses of first-line drugs.…”

Section: Introductionmentioning

confidence: 99%

Challenges & Solutions for Recent Advancements in Multi-Drugs Resistance Tuberculosis: A Review

Yadav

2023

Microbiol�Insights

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In MDR-TB, mycobacterium is resistant to battlefront drugs like rifampicin and isoniazid. Now it’s an urgent global challenge for treatment & diagnosis because more than 50% of drugs are resistant. Till today's information, 5 reasons are liable for MDR: (1) Errors of physicians/patients in therapy management, (2) Complexity and poor vascularization of granulomatous lesions, which obstruct drug distribution to some sites, leading to resistance development, (3) Intrinsic drug resistance of tubercle bacilli, (4) Formation of non-replicating, drug-tolerant bacilli inside the granulomas, (5) Development of mutations in Mtb genes, which are the foremost important molecular mechanisms of resistance. the most contribution of this work is a brief & clear explanation of things chargeable for resistant development, and recent diagnostic & treatment methods for MDR-TB. This study shall help researchers & scientists to develop replacement rapid diagnostic tools, drugs, and treatment protocols.

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Failures in Medication Safety in the Intensive Care Unit and Ward

Merry

Wahr

2021

Medication Safety During Anesthesia and the Perioperative Period

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Medication errors with antituberculosis therapy in an inpatient, academic setting: forgotten but not gone

Abstract: Medication errors associated with antituberculosis therapy remain a common occurrence in the current clinical practice setting. Greater vigilance when prescribing medications for tuberculosis disease is needed.

Cited by 3 publications

References 7 publications

Drug therapy problems for patients with tuberculosis and HIV/AIDS at a reference hospital

Drug therapy problems for patients with tuberculosis and HIV/AIDS at a reference hospital

Challenges & Solutions for Recent Advancements in Multi-Drugs Resistance Tuberculosis: A Review

Failures in Medication Safety in the Intensive Care Unit and Ward

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