Medication errors in Parkinson's disease inpatients in the Basque Country

Lertxundi, Unax; Isla, Arantxazu; Solinís, Maria Ángelés; Domingo-Echaburu, Saioa; Hernández, Rafael; Peral-Aguirregoitia, Javier; Medrano, Juan; García-Moncó, Juan Carlos

doi:10.1016/j.parkreldis.2016.12.028

Cited by 31 publications

(32 citation statements)

References 20 publications

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“…Hospitalization of people with PD can precipitate motor deterioration [ 43 ] in part due to drug errors, which are common amongst PD inpatients and increase length of stay [ 44 ]. Development of delirium, commonly encountered during hospital admissions, may modify the disease trajectory [ 45 ].…”

Section: Implications For Clinical Practice: Prescribing and Hospitalmentioning

confidence: 99%

Multimorbidity and Frailty: Tackling Complexity in Parkinson’s Disease

Tenison

Henderson

2020

JPD

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Parkinson’s disease (PD) is a condition that predominantly affects older people. It is imperative that clinical management considers the other significant illnesses that people with PD accumulate as they age in conjunction with their resilience to cope with physiological change. Multimorbidity and frailty act synergistically to heighten the risk of adverse outcomes for older people with PD. These states are associated with increased likelihood of hospitalization, polypharmacy, adverse drug effects including the anticholinergic burden of medications, drug-disease and drug-drug interactions. Management should be integrated, holistic and individualised to meticulously balance the risks of interventions considering the vulnerability of the individual to recover from disturbance to their environmental, physical and cognitive equilibrium.

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Section: Implications For Clinical Practice: Prescribing and Hospitalmentioning

confidence: 99%

Multimorbidity and Frailty: Tackling Complexity in Parkinson’s Disease

Tenison

Henderson

2020

JPD

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“…An internet based literature search, was conducted using terms: "levodopa", "hospital", "Parkinson's Disease", "Missed doses", "Guidelines" and found evidence of: poor prescribing practices and frequent drug administration errors in hospitalised PD patients. [3][4][5][6][7][8][9][10][11] Details of the medication administration components were extracted from the PD Guidelines (Table 1). Common themes were identified and these included: missed and delayed levodopa doses, inappropriate withholding of medications in PD patients during hospital admissions, changing drug regimens to fit hospital drug administration schedules and prescribing of contraindicated antidopaminergic drugs to PD patients in hospital.…”

Section: Issues Identified With Pd Medications In Hospitalmentioning

confidence: 99%

“On time ‐ every time” A new strategy for dosing levodopa in hospital

Ortiz

2020

Pharmacy Practice and Res

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Most Parkinson’s Disease (PD) patients are hospitalised for reasons other than their PD. Their PD symptoms are usually under control before admission, however, too many seem to experience medication‐related problems in hospital. Hospitalised PD patients should receive their levodopa within 30 min of the scheduled time (“on time”) and not miss doses (“every time”). Hospital staff should avoid prescribing and administering contraindicated dopamine antagonists to PD patients in their care. Multiple studies have shown the failure to deliver levodopa “on time” to PD patients, with less than 50% of doses being “on time” and an average 0.7 of doses missed each day. The evidence points to hospital medication administration systems (HMAS) as the likely cause of late and missed levodopa doses. PD medication administration guidelines were reviewed to find strategies that reduced late and missed doses. An integrated “on time – every time” medication administration approach is proposed. PD patients should be encouraged to self‐administer their medication in hospital. More PD nurse navigators will be needed to facilitate PD patient care in Australian hospitals.

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“…metaclopramide, administration), on inpatients with PD [7,8]. Such errors were associated with increased length of hospitalization [7,8] and a higher mortality rate [7]. In one of these studies, neurologists were consulted in less than one quarter of the inpatient encounters [8].…”

Section: Vignettementioning

confidence: 99%