It is dopey to stop giving dopamine to hospitalized patients with Parkinson’s disease

Margolesky, Jason; Singer, Carlos

doi:10.1080/14737175.2017.1392857

Cited by 4 publications

(3 citation statements)

References 17 publications

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“…Negative predictors for tumor progression in meningioma include male sex, young age, low Karnofsky performance status, high WHO grade, high mitotic rate, subtotal resection, and involvement of the optic nerve [ 24 ]. A high MIB-1 labeling index is strongly associated with shorter progression-free survival in meningioma and positively correlates with the meningioma grade [ 13 , 25 , 26 ].…”

Section: Discussionmentioning

confidence: 99%

FORGE: A Novel Scoring System to Predict the MIB-1 Labeling Index in Intracranial Meningiomas

Wach

Lampmann

Güresir

et al. 2021

Cancers

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The MIB-1 index is an essential predictor of progression-free-survival (PFS) in meningioma. To date, the MIB-1 index is not available in preoperative treatment planning. A preoperative score estimating the MIB-1 index in patients with intracranial meningiomas has not been investigated so far. Between 2013 and 2019, 208 patients with tumor morphology data, MIB-1 index data, and plasma fibrinogen and serum C-reactive protein (CRP) data underwent surgery for intracranial WHO grade I and II meningioma. An optimal MIB-1 index cut-off value (≥6/<6) in the prediction of recurrence was determined by ROC curve analysis (AUC: 0.71; 95% CI: 0.55–0.87). A high MIB-1 index (≥6%) was present in 50 cases (24.0%) and was significantly associated with male sex, peritumoral edema, low baseline CRP, and low fibrinogen level in the multivariate analysis. A scoring system (“FORGE”) based on sex, peritumoral edema, preoperative CRP value, and plasma fibrinogen level supports prediction of the MIB-1 index (sensitivity 62%, specificity 79%). The MIB-1 labeling index and the FORGE score are significantly associated with an increased risk of poor PFS time. We suggest a novel score (“FORGE”) to preoperatively estimate the risk of an increased MIB-1 index (≥6%), which might help in surgical decision making and follow-up interval determination and inform future trials investigating inflammatory burden and proliferative activity.

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Section: Discussionmentioning

confidence: 99%

FORGE: A Novel Scoring System to Predict the MIB-1 Labeling Index in Intracranial Meningiomas

Wach

Lampmann

Güresir

et al. 2021

Cancers

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“…Negative prognostic factors in meningiomas include young age, male gender, low Karnofsky performance status, high grade, high mitotic rate, subtotal surgical resection, and involvement of the optic nerve. [ 67 ] Among these factors, histological grading is the most important determinant of prognosis. Nevertheless, it has been proved inadequate in evaluating the survival outcomes.…”

Section: Discussionmentioning

confidence: 99%

The prognostic role of Ki-67/MIB-1 in meningioma

et al. 2020

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“…The consequences are particularly pronounced when PD patients are admitted to the hospital where rigid medication schedules, lack of PD knowledge among hospital staff, and limited availability of PD medications on hospital formularies can lead to missed or delayed dosing, medication substitutions, or even administration of contraindicated medications (Derry et al, 2010;Chou et al, 2011;Cohen and Smetzer, 2015;Shin and Habermann, 2016;Lertxundi et al, 2017;Mucksavage and Kim, 2020). These errors increase complication rates and prolong hospital stays (Barber et al, 2001;Derry et al, 2010;Gerlach et al, 2012;Carlson et al, 2014;Cohen and Smetzer, 2015;Martinez-Ramirez et al, 2015;Crispo et al, 2016;Lertxundi et al, 2017;Cox et al, 2018;Margolesky and Singer, 2018;Yu et al, 2023). Delays in medication administration of even 15 min have been shown to result in negative outcomes for PD patients (Parkinson's Foundation, 2022).…”

Section: Introductionmentioning

confidence: 99%

Custom order entry for Parkinson’s medications in the hospital improves timely administration: an analysis of over 31,000 medication doses

Azmi,

Cocoziello,

Ruzicka

et al. 2023

Front. Aging Neurosci.

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BackgroundPatients with Parkinson’s disease (PD) are at increased risk for hospital acquired complications. Deviations from home medication schedules and delays in administration are major contributing factors. We had previously developed a protocol to ensure adherence to home medication schedules using “custom” ordering. In this study we are assessing the impact this order type may have on reducing delays in PD medication administration in the hospital.Material and methodsWe reviewed 31,404 orders placed for PD medications from January 2, 2016 to April 30 2021. We evaluated the orders to determine if they were placed in a Custom format or using a default non-custom order entry. We further evaluated all orders to determine if there was a relationship with the order type and timely administration of medications. We compared medications that were administered within 1 min, 15 min, 30 min and 60 min of due times across custom orders vs. non-custom default orders. We also evaluated the relationship between ordering providers and type of orders placed as well as hospital unit and type of orders placed.Results14,204 (45.23%) orders were placed using a custom schedule and 17,200 (54.77%) orders were placed using non-custom defaults. The custom group showed a significantly lower median delay of 3.06 minutes compared to the non-custom group (p<.001). Custom orders had a significantly more recent median date than non-custom default orders (2019-10-07 vs. 2018-01-06, p<0.001). In additional analyses, medication administration delays were significantly improved for custom orders compared to non-custom orders, with likelihoods 1.64 times higher within 1 minute, 1.40 times higher within 15 minutes, and 1.33 times higher within 30 minutes of the due time (p<0.001 for all comparisons).ConclusionThis is the largest study to date examining the effects of order entry type on timely administration of PD medications in the hospital. Orders placed using a custom schedule may help reduce delays in administration of PD medications.

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It is dopey to stop giving dopamine to hospitalized patients with Parkinson’s disease

Cited by 4 publications

References 17 publications

FORGE: A Novel Scoring System to Predict the MIB-1 Labeling Index in Intracranial Meningiomas

FORGE: A Novel Scoring System to Predict the MIB-1 Labeling Index in Intracranial Meningiomas

The prognostic role of Ki-67/MIB-1 in meningioma

Custom order entry for Parkinson’s medications in the hospital improves timely administration: an analysis of over 31,000 medication doses

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