Medication Assisted Treatment in the Treatment of Drug Abuse and Dependence in HIV/AIDS Infected Drug Users

Kresina, Thomas F.; Bruce, Robert D.; McCance‐Katz, Elinore F.

doi:10.2174/157016209788680598

Cited by 11 publications

(6 citation statements)

References 92 publications

(97 reference statements)

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“…Previous studies have indicated that HIV-positive IDUs experience comparatively low rates of access and adherence to HIV treatment, and consequently this population has not benefited from modern HIV treatments to the same extent that other HIV-affected populations have (Kresina, Bruce, & McCance-Katz, 2009; Wood et al, 2003). Given that the SIF in Vancouver is attracting high-risk IDUs with a lower likelihood of receiving HIV treatment, the SIF could provide a venue for enhanced HIV care, including viral load and CD4 count testing, vaccinations and other preventive measures, and distribution of antiretroviral therapies.…”

Section: Discussionmentioning

confidence: 99%

Use of North America's First Medically Supervised Safer Injecting Facility Among HIV-Positive Injection Drug Users

Reddon

Wood²,

Tyndall³

et al. 2011

AIDS Education and Prevention

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The objective of this study was to examine supervised injecting facility (SIF) use among a cohort of 395 HIV-positive injection drug users (IDUs) in Vancouver, Canada. The correlates of SIF use were identified using generalized estimating equation analyses. In multivariate analyses, frequent SIF use was associated with homelessness (adjusted odds ratio [AOR] = 1.90), daily heroin injection (AOR = 1.56), and daily cocaine injection (AOR = 1.59). The reasons given for not using the SIF included a preference for injecting at home and already having a safe place to inject. The SIF services most commonly used were needle exchange and nursing services. The SIF appears to have attracted a high-risk subpopulation of HIV-positive IDUs; this coverage perhaps could be extended with the addition of HIV- specific services such as disease monitoring and the provision of antiretroviral therapy.

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Section: Discussionmentioning

confidence: 99%

Use of North America's First Medically Supervised Safer Injecting Facility Among HIV-Positive Injection Drug Users

Reddon

Wood²,

Tyndall³

et al. 2011

AIDS Education and Prevention

View full text Add to dashboard Cite

show abstract

“…Opioid substitution therapy (OST), in particular methadone maintenance therapy (MMT) and buprenorphine-naloxone (BUP), has been shown to be effective in reducing opioid use, preventing relapse, and enhancing ART and HIV treatment adherence among people with HIV/AIDS [66][67][68]. Recent work suggests that the context and delivery of OST may affect HIV treatment attendance and drug use cessation rates.…”

Section: Heroinmentioning

confidence: 99%

Substance Use: Impact on Adherence and HIV Medical Treatment

2011

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Substance use is highly prevalent among people living with HIV/AIDS, is often comorbid with other mental health problems, related to poor HIV medical outcomes, and, is associated with poor medication and treatment adherence. The current review reports on the recent state of the literature in terms of substance use and its relation to HIV medication and treatment adherence, and offers recommendations for advancing treatment and secondary HIV prevention efforts. Identifying substance users within HIV primary care and developing, evaluating, and refining integrative substance use-mental health-adherence interventions may be clinically important targets for effective disease management and may contribute to secondary HIV prevention efforts.

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“…Substance use in HIV-infected patients has been linked to poor ART adherence, low access to care, low health-related quality of life, and impairment of physical and mental health (Korthuis et al, 2008;Kresina, Bruce, & McCance-Katz, 2009;Lima et al, 2014;).…”

Section: Introductionmentioning

confidence: 99%

Alcohol dependence and CD4 cell count: is there a relationship?

2014

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Alcohol and other drugs use seem to be common among people infected with HIV on antiretroviral treatment (ART). Their effects on HIV progression is still in debate. This study aimed to assess the association between alcohol and drug use and an HIV disease progression biomarker (CD4 cell count) among patients on ART. A cross-sectional study was carried out at an HIV treatment center affiliated with Medical School of the University of São Paulo, Brazil. Four hundred and thirty-eight HIV-positive patients on ART were interviewed by trained psychiatrists and psychologists using the following instruments: Structured Clinical Interview for DSM-IV Axis I Disorders (SCID-I), Alcohol Use Disorders Identification Test (AUDIT), 17-item Hamilton Rating Scale for Depression, and the Simplified Medication Adherence Questionnaire (SMAQ). In the previous month, 219 (50%) and 41 (9.3%) patients reported use of alcohol and illicit drugs, respectively. Fifty patients (12.6%) were classified as having harmful alcohol use by AUDIT. According to SCID-I, 80 patients (18.3%) were alcohol abusers, 24 (5.5%) alcohol dependents, and 21 (4.2%) had a current depressive disorder. Almost 73% (n = 319-72.8%) of the patients were adherent to ART. Alcohol dependents were nine times (p < 0.01) more likely to have CD4 cell count ≤200/mm(3), and this association was independent of ART adherence. In conclusion, alcohol dependence seems to be associated with low CD4 cell count in HIV-positive patients. Based on these data, HIV health care workers should always assess alcohol consumption in the treatment setting, and patients should be advised that alcohol dependence may be linked to low CD4.

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Medication Assisted Treatment in the Treatment of Drug Abuse and Dependence in HIV/AIDS Infected Drug Users

Cited by 11 publications

References 92 publications

Use of North America's First Medically Supervised Safer Injecting Facility Among HIV-Positive Injection Drug Users

Use of North America's First Medically Supervised Safer Injecting Facility Among HIV-Positive Injection Drug Users

Substance Use: Impact on Adherence and HIV Medical Treatment

Alcohol dependence and CD4 cell count: is there a relationship?

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