Medication adherence in epilepsy and potential risk factors associated with non adherence in tertiary care teaching hospital in southwest Ethiopia

Getachew, Hiwot; Dekema, Nezif H; Awol, Sofia S; Abdi, Alinur Adem; Mohammed, Mohammed Adem

doi:10.5455/gmj-30-45904

Cited by 18 publications

(23 citation statements)

References 11 publications

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“…A study conducted in Finland indicated the prevalence of AEDs nonadherence as 34% and nonadherence was higher in individuals who smoke cigarette and drink alcohol [11]. In sub-Saharan African countries, prevalence of antiepileptic drug nonadherence is significant which was about 67% in Nigeria, 54% in Kenya, and 37% in Ethiopia and financial factors were the significant predictors of nonadherence [8, 12–14]. …”

Section: Introductionmentioning

confidence: 99%

Antiepileptic Drug Nonadherence and Its Predictors among People with Epilepsy

Getnet¹,

Woldeyohannes

Bekana³

et al. 2016

Behavioural Neurology

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Introduction. Antiepileptic drugs are effective in the treatment of epilepsy to the extent that about 70% of people with epilepsy can be seizure-free, but poor adherence to medication is major problem to sustained remission and functional restoration. The aim of this study was to assess the prevalence and associated factors of antiepileptic drug nonadherence. Methods. Cross-sectional study was conducted on 450 individuals who were selected by systematic random sampling method. Antiepileptic drug nonadherence was measured by Morisky Medication Adherence Scale (MMAS) and logistic regression was used to look for significant associations. Result. The prevalence of AEDs nonadherence was 37.8%. Being on treatment for 6 years and above [AOR = 3.47, 95% CI: 1.88, 6.40], payment for AEDs [AOR = 2.76, 95% CI: 1.73, 4.42], lack of health information [AOR = 2.20, 95% CI: 1.41,3.43], poor social support [AOR = 1.88, 95%, CI: 1.01, 3.50], perceived stigma [AOR = 2.27, 95% CI: 1.45, 3.56], and experience side effect [AOR = 1.70, 95% CI: 1.06, 2.72] were significantly associated with antiepileptic drug nonadherence. Conclusion. More than one-third of people with epilepsy were not compliant with their AEDs. Giving health information about epilepsy and its management and consequent reduction in stigma will help for medication adherence.

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Section: Introductionmentioning

confidence: 99%

Antiepileptic Drug Nonadherence and Its Predictors among People with Epilepsy

Getnet¹,

Woldeyohannes

Bekana³

et al. 2016

Behavioural Neurology

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“…(12). In the study conducted by Getachew et al (2014), it was concluded that the rate of the patients' adherence to medication regimen is low. The most important reason for non-adherence to medication program were forgetfulness, lack of information regarding the importance of the amount and frequency of medication use, and the decision to stop taking medication (13).…”

Section: Total Adherencementioning

confidence: 99%

“…In the study conducted by Getachew et al (2014), it was concluded that the rate of the patients' adherence to medication regimen is low. The most important reason for non-adherence to medication program were forgetfulness, lack of information regarding the importance of the amount and frequency of medication use, and the decision to stop taking medication (13). Considering the reasons for non-adherence, there is a need to increase the patient's knowledge on the importance of medication use and family training in order to accompany the patient (14).…”

Section: Total Adherencementioning

confidence: 99%

The Effect of Family-Centered Empowerment Model on Treatment Plans Adherence of Patients Undergoing Coronary Artery Bypass Graft

Sanaie¹,

Bahramnezhad²,

Zolfaghari³

et al. 2016

Crit Care Nurs J

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Background: Coronary artery diseases are among the most important causes of disability and coronary artery bypass graft (CABG) surgery is considered as one of the most important methods of treatment. The improvement of post-surgery adherence to treatment plan is one of the main healthcare objectives. Objectives: The present study attempted to determine the effect of family-centered empowerment model on the adherence of patients undergoing CABG to the treatment plans. Methods: This research was a clinical trial and a quasi-experimental study, including pre and post tests with a control group performed on 102 patients and active family members of the patients hospitalized at the intensive care unit (ICU) of Imam Khomeini hospital of Tehran, Iran in 2014. For the experimental group, the family-centered empowerment model was implemented with four steps. The control group received only common care. The rate of patients' adherence to the treatment plans was then investigated in three areas of diet, medication, and physical activities before and after the intervention, and the data were analyzed using PASW Statistics V18 software. Results: The two groups were similar in terms of demographic variables. After the intervention, there was a significant difference based on the results of the independent T-test in terms of mean scores of adherence to the treatment plan in the three areas mentioned above (P = 0.000). Also, before and after the intervention, a significant difference was observed in the experimental group in terms of the above mean scores (P = 0.000). Conclusions: Based on the research findings, the family-centered empowerment model seems to be practical and feasible for the patients under CABG, which can bring improvement or correction of adherence to the treatment plan.

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“…AEDs nonadherence will also lead to increase burden of inpatient and emergency department services (17,18). There was a negative relation between medication adherence and frequency of seizures.…”

Section: Introductionmentioning

confidence: 99%

“…The value of ''p''( p= proportion of prevalence) was taken as 36.8% of antiepileptic drug nonadherence from a study conducted in Jimma University specialized hospital, Southwest Ethiopia to estimate the sample size (17), total sample size for this study is 359. Then the total source of population are 725 that means less than 10,000; therefore it was used correction formula and by considering 10% non response rate, so final sample size 265.…”

Section: Sample Size Determination and Techniquementioning

confidence: 99%

Prevalence and Associated Factors of Antiepileptic Drugnonadherence Among Epileptic Patients Attending at Out Patient Departement of Dilla University Referral Hospital, Dilla,gedeo,snnpr, Southern Ethiopia

2017

IJBM

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Background: Antiepileptic drugs are effective in the treatment of epilepsy, but poor adherence to medication is major problem to sustained remission and to functional restoration. Poor adherence to treatment is one of many reasons for pharmacological treatment failure and seizure recurrence. Even though there were studies on the magnitude and associated factors of Antiepileptic drugs non-adherence, there is a shortage of published information regarding the prevalence and associated factors of Antiepileptic drugs none-adherence in Ethiopia. Objective: To assess prevalence and associated factors of antiepileptic drug none-adherence among epileptic patients attending at Dilla University Referral Hospital. Methods: Institutional based cross sectional study design was conducted at Dilla University Referral Hospital from March to May, 2016. A total of 265 individuals was selected by simplerandom sampling method and interviewed by using structured questionnaire. 8 itemMorisky Medication Adherence Scalewas used to assess the prevalence of antiepileptic drug non adherence. Data was coded and exported to SPSS version 20 for analysis. Results: The prevalence of Antiepileptic's drug none-adherence in this study was 38. .48, 95%, CI: 0.722,3.035] were found to be significantly associated (p<0.05). Conclusion: The prevalence of antiepileptic drug none-adherence among patients with epilepsy disorder was found 38.1%. Getting medication by payment, did not receive health information about (the illness, duration of treatment, medication side effect), skip dose, on treatment for 2-5 years, and poor social support were found to be the independent predictor of antiepileptic drug none-adherence.

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Medication adherence in epilepsy and potential risk factors associated with non adherence in tertiary care teaching hospital in southwest Ethiopia

Cited by 18 publications

References 11 publications

Antiepileptic Drug Nonadherence and Its Predictors among People with Epilepsy

Antiepileptic Drug Nonadherence and Its Predictors among People with Epilepsy

The Effect of Family-Centered Empowerment Model on Treatment Plans Adherence of Patients Undergoing Coronary Artery Bypass Graft

Prevalence and Associated Factors of Antiepileptic Drugnonadherence Among Epileptic Patients Attending at Out Patient Departement of Dilla University Referral Hospital, Dilla,gedeo,snnpr, Southern Ethiopia

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