Abstract:ObjectiveDiabetes is a global problem with devastating human, social and economic impact. Anti-diabetic medications play a major role in the glycemic control of patients with diabetes. However, inadequate adherence compromises safety and treatment effectiveness, leading to increased mortality and morbidity. The aim of this study was to assess adherence to anti-diabetic medications and associated factors among patient with diabetes mellitus receiving care at Zewditu Memorial Hospital.ResultsAmong the total of 1… Show more
“…In terms of educational status, having primary or secondary level of education decreased the odds of participants being non-adherent to their antidiabetic medication by 58%. This might be explained by the participants ability to read and understand the importance of their adherence to their medication and is consistent with studies conducted in different settings of Ethiopia by Kassahun et al [17], Jemal et al [15], and Ali et al [36] and one study conducted in India by Sajith et al…”
Background: Poor adherence to the medical regimen is a major clinical problem in the management of patients with diabetes. This study sought to investigate the level of medication adherence to antidiabetic therapy and to identify possible predictors of poor adherence. Methods: A hospital based cross-sectional study was conducted from July 2018 to June 2019 among randomly selected follow-up T2D patients at a hospital diabetes clinic. Data were collected through patient interviews, followed by medical chart review. Adherence to antidiabetic therapy that we assessed patients' responses using validated Brief Medication Questionnaire (BMQ). To identify predictors of poor medication adherence, binary logistic regression analyses were performed using SPSS version 25. Statistical significance was set at p value ≤ 0.05. Results: Of the total 357 study participants, 25% were non-adherent to their antidiabetic therapy. Predictors statistically associated with poor adherence were; being female gender (AOR = 1.71, 95% CI 1.01-2.76), and presence of at least one diabetic complication (AOR = 2.02, 95% CI 1.02-3.22). Participants with having at least primary level of education were more likely to adhere to anti-diabetes medication (AOR = 0.42, 95% CI 0.18-0.96). The most common self-reported reasons for non-adherence were forgetfulness, unavailability of medication plus the unaffordability of anti-diabetes medications. Conclusions: The proportion of participants' adherent to anti-diabetes therapies was suboptimal. Being female, the presence of chronic diabetic complications and having no formal education were the main predictors of poor adherence. Strategies that aimed at improving adherence to antidiabetic medications deemed to be compulsory.
“…In terms of educational status, having primary or secondary level of education decreased the odds of participants being non-adherent to their antidiabetic medication by 58%. This might be explained by the participants ability to read and understand the importance of their adherence to their medication and is consistent with studies conducted in different settings of Ethiopia by Kassahun et al [17], Jemal et al [15], and Ali et al [36] and one study conducted in India by Sajith et al…”
Background: Poor adherence to the medical regimen is a major clinical problem in the management of patients with diabetes. This study sought to investigate the level of medication adherence to antidiabetic therapy and to identify possible predictors of poor adherence. Methods: A hospital based cross-sectional study was conducted from July 2018 to June 2019 among randomly selected follow-up T2D patients at a hospital diabetes clinic. Data were collected through patient interviews, followed by medical chart review. Adherence to antidiabetic therapy that we assessed patients' responses using validated Brief Medication Questionnaire (BMQ). To identify predictors of poor medication adherence, binary logistic regression analyses were performed using SPSS version 25. Statistical significance was set at p value ≤ 0.05. Results: Of the total 357 study participants, 25% were non-adherent to their antidiabetic therapy. Predictors statistically associated with poor adherence were; being female gender (AOR = 1.71, 95% CI 1.01-2.76), and presence of at least one diabetic complication (AOR = 2.02, 95% CI 1.02-3.22). Participants with having at least primary level of education were more likely to adhere to anti-diabetes medication (AOR = 0.42, 95% CI 0.18-0.96). The most common self-reported reasons for non-adherence were forgetfulness, unavailability of medication plus the unaffordability of anti-diabetes medications. Conclusions: The proportion of participants' adherent to anti-diabetes therapies was suboptimal. Being female, the presence of chronic diabetic complications and having no formal education were the main predictors of poor adherence. Strategies that aimed at improving adherence to antidiabetic medications deemed to be compulsory.
“…This percentage was closer to a study conducted in India [48] and some studies in Ethiopia [49–51]. It was, however, lower compared to other studies conducted in Ethiopia [52–56] and higher than a study conducted in Uganda [57]. Factors including presence of diabetes complication, female gender, primary and secondary levels of education were demonstrated to be independently associated with level of adherence.…”
BackgroundPatients with diabetes are at high risk of drug therapy problems (DTPs), as they are receiving multiple medications. To date, studies regarding DTPs in patients with diabetes in Ethiopia are limited. The aim of this study was to assess prevalence of DTPs, medication adherence and treatment satisfaction of patients with diabetes at Tikur Anbessa Specialized Hospital (TASH).MethodA cross-sectional study was conducted on randomly selected 418 participants who fulfilled the inclusion criteria. Data were collected using structured questionnaire and patients’ chart review. Cipolle’s classification system was used to determine DTPs. Modified Morisky’s Adherence Scale (MMAS-8) was used to measure patients’ adherence to their medication. Treatment Satisfaction with Medicines Questionnaire (SATMED-Q) patient satisfaction assessment questionnaire was used to assess patients’ treatment satisfaction.ResultsA total of 207 DTPs in 177 (42.3%) of participants were identified. Commonly identified DTPs were dosage too low (58, 28.0%), ineffective drug therapy (54, 26.1%), and need additional drug therapy (52, 25.1%). Factors associated with DTPs were female gender (Adjusted Odds Ratio [AOR] = 2.31,95% CI:1.30–4.12); ≥3comorbidities (AOR = 3.61, 95% CI:1.19–10.96); ever married (AOR = 2.58,95% CI:1.23–5.48); type 2 diabetes (AOR = 5.62, 95% CI:1.21–26.04); non-adherence (AOR = 5.26,95% CI:2.51–11.04) and residence out of Addis Ababa (AOR = 0.30, 95% CI:0.12–0.73). Twenty four percent of participants were non-adherent to their drug therapies. Factors associated with non-adherence were diabetes complications (AOR = 2.00, 95% CI: 1.2–3.32), the female gender (AOR = 1.67, 95%CI: 1.01–2.8) and level of education (AOR = 0.42, 95%CI: 0.18–0.96). Eighty one percent of participants were satisfied with the current treatment.ConclusionA significant proportion of patients were satisfied with their treatment and a quarter of the study participants were non-adherent to their medications at TASH diabetic clinic. However, DTPs were considerably higher among the study participants. Hence, future interventions targeting prevention and resolution of DTPs deemed to be necessary.
“…Ten articles were excluded based on their lack of clarity in terms of the outcome variable. The remaining 26 studies 37 , 38 , 39 , 40 , 41 , 42 , 43 , 44 , 45 , 46 , 47 , 48 , 49 , 50 , 51 , 52 , 53 , 54 , 55 , 56 , 57 , 58 , 59 , 60 met the inclusion criteria and were included in the final analysis ( Figure 1 ). Figure 1 Flow diagram showing the procedure of selecting studies for meta-analysis in Ethiopia 2013–2019.…”
Section: Resultsmentioning
confidence: 99%
“…Twenty-six studies representing 7756 patients with diabetes were included in the final analysis. From the included studies, eight observational studies (27%) were conducted in Oromia region, 38 , 47 , 48 , 52 , 53 , 55 8 articles (30.8%) were from Addis Ababa, 39 , 41 , 43 , 45 , 46 , 49 , 50 5 articles (19.2%) were from Amhara region, 40 , 44 , 54 , 56 , 60 and 2 articles were from the Southern Nations, Nationalities, and People's Region 51 , 59 and Tigray regions. 37 , 57 The remaining 1 article was from Harari region.…”
Highlights
Seven thousand seven hundred fifty-six participants were included for the final analysis.
Reported good medication adherence among adult diabetic patients in Ethiopia was 68.59%.
Reported good medication adherence among adult diabetic patients in regions was 67.81%.
Reported good medication adherence among adult diabetic patients in Addis Ababa was 70.37%.
Presence of glucometer at home has positive association with reported good medication adherence among adult diabetic patients.
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