Medicated prevention of scarring after glaucoma surgery

Germanova, V N; Карлова, Е. В.; Золотарев, А. В.

doi:10.17116/oftalma2020136041130

Cited by 6 publications

(4 citation statements)

References 34 publications

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“…The success rate of glaucoma drainage device implantation is influenced by several key risk factors. In the case of distal outflow, bleb-forming devices, these include the obstruction of aqueous humor egress due to inflammation-driven excessive fibrosis often leading to encapsulation of the drainage device or blockage of the devices outflow channels [ 12 – 14 ]. Glaucoma drainage tube or devices, which have one end located in the anterior chamber for an extended period, carry the risk of continuous friction with the corneal endothelium.…”

Section: Discussionmentioning

confidence: 99%

Intraocular pressure control efficacy and safety of HA-Mg glaucoma drainage plate implantation in the anterior chamber of rabbit eyes

Cai,

Luo,

Feng

et al. 2024

J Mater Sci: Mater Med

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The current clinical application of glaucoma drainage devices is made of non-degradable materials. These non-degradable drainage devices often trigger inflammatory responses and scar proliferation, possibly leading to surgical failure. We developed a biodegradable material hydroxyapatite-coated magnesium (HA-Mg) as a glaucoma drainage device. Twelve New Zealand white rabbits were randomly assigned to three groups: HA-Mg drainage plate group (6 right eyes), trabeculectomy group (6 right eyes), and control group (12 left eyes). Results showed that all HA-Mg drainage plates were completely degraded ~4 months postoperatively. At the 5th month postoperatively, there was no statistical difference in the corneal endothelium density between the HA-Mg drainage plate group and the control group (p = 0.857). The intraocular pressure (IOP) level in the HA-Mg drainage plate implantation group was lower than in the other two groups. The trypan blue dye still drained from the anterior chamber to the subconjunctiva 5 months after HA-Mg drainage plate implantation. HE staining revealed the scleral linear aqueous humor drainage channel and anterior synechia were observed after drainage plate completely degraded, with no obvious infiltration with the inflammatory cells. This study showed the safety and efficacy of HA-Mg glaucoma drainage plate in controlling IOP after implantation into the anterior chamber of rabbit eyes. Graphical abstract

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Section: Discussionmentioning

confidence: 99%

Intraocular pressure control efficacy and safety of HA-Mg glaucoma drainage plate implantation in the anterior chamber of rabbit eyes

Cai,

Luo,

Feng

et al. 2024

J Mater Sci: Mater Med

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“…The increase in the expression of collagen I, fibronectin and other extracellular matrix proteins is an important pathological process in wound fibrosis and scar formation. 15,20 Shukla et al 21 found that transforming growth factor (TGF)-β1-induced extracellular matrix synthesis could be reduced by inhibiting the expression of the chloride channel CLIC4. Moreover, chloride channels CLIC1, CLIC4 and CLIC5 play a regulatory role in the pathogenesis of atrial fibrillation by participating in the synthesis of collagen IV.…”

Section: Discussionmentioning

confidence: 99%

“…Scar formation is primarily related to the increased synthesis of collagen fibres and the proliferation of fibroblasts and muscle fibroblasts. The increase in the expression of collagen I, fibronectin and other extracellular matrix proteins is an important pathological process in wound fibrosis and scar formation 15,20 . Shukla et al 21 found that transforming growth factor (TGF)‐β1‐induced extracellular matrix synthesis could be reduced by inhibiting the expression of the chloride channel CLIC4.…”

Section: Discussionmentioning

confidence: 99%

Role of the chloride channel blocker in the formation of filtering tract scars after glaucoma surgery in rats

Jin

Sun

et al. 2023

Clin Exp Pharma Physio

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Filtration surgery is commonly performed for glaucoma treatment to reduce intraocular pressure (IOP); however, scarring of the filtering bleb is the main cause of failure. In this study, we evaluated the effects of the chloride channel blocker 5‐nitro‐2‐(3‐phenylpropylamino)benzoic acid (NPPB) on scar formation in filtering blebs. A glaucoma filtering surgery model was generated using Sprague–Dawley rats, divided into the control and NPPB groups receiving injections of different NPPB concentrations. The IOP of all rats decreased 1‐day post‐surgery and gradually increased afterward. However, IOP in rats from the NPPB groups recovered more slowly than that of the control group rats. In addition, the area and survival times of filtering blebs in rats from the NPPB groups were substantially larger and longer than those in the control group. Twenty‐eight days after surgery, the protein and mRNA expression of collagen I, fibronectin and α‐smooth muscle actin in the filtering area of rats from the NPPB groups were significantly lower than that in the control group rats. Collectively, our study demonstrates that NPPB inhibits filtering bleb scar formation, maintains filtering bleb morphology and prolongs filtering bleb survival time by inhibiting the differentiation of conjunctival fibroblasts and extracellular matrix synthesis.

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“…Die größte Problematik der chirurgischen Glaukomtherapie, insbesondere bei der Trabekulek- tomie (TE), stellen nach wie vor postoperative Vernarbungsprozesse dar [8]. Durch Proliferation von Bindegewebe im Bereich des Filterkissens wird der Kammerwasserabfluss behindert, wodurch ein erneuter Druckanstieg resultiert [7]. Die Erfolgsrate der TE ist demnach erheblich von der Wundheilung abhängig.…”

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Trabekulektomie mit Mitomycin C und Ologen®-Implantat im Vergleich zur klassischen Trabekulektomie

et al. 2022

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Zusammenfassung Hintergrund Die Trabekulektomie (TE) mit Mitomycin C (MMC) gilt als Goldstandard der Glaukomchirurgie. Eine neuere Modifikation ist die Verwendung von Ologen®-Implantaten (AEON Astron Europe B.V., Leiden, Niederlande) bei der TE, die in dieser Studie bewertet und mit der klassischen TE verglichen werden soll. Patienten und Methoden In die Studie wurden 98 Augen nach TE mit MMC (Gruppe 1) sowie 70 Augen nach TE mit Ologen® und MMC (Gruppe 2) aufgenommen. Beide Gruppen wurden hinsichtlich des intraokulären Drucks (IOD), der medikamentösen Glaukomtherapie sowie Komplikationen und Nachbehandlungen verglichen. Die Daten wurden präoperativ und bis 2 Jahre postoperativ erhoben. Ergebnisse In Gruppe 1 verringerte sich der IOD von 28,0 mmHg (95 %-Konfidenzintervall: 26,6–29,4 mmHg) präoperativ auf 16,0 mmHg (14,0–18,1) nach 2 Jahren. In Gruppe 2 wurde der IOD von 28,5 mmHg (26,8–30,1) auf 14,3 mmHg (11,7–17) gesenkt. Zu allen Zeitpunkten war die Drucksenkung in beiden Gruppen signifikant (p < 0,001), zwischen den Gruppen bestand kein Unterschied (p > 0,05). Alle glaukomspezifischen Nachbehandlungen waren in Gruppe 1 häufiger, jedoch nicht signifikant. Schlussfolgerung Beide Verfahren zeigten sich gleichwertig effektiv bezüglich der IOD-Reduktion. In unserer Studienpopulation waren nach TE mit Ologen® weniger Nachbehandlungen und folglich seltener Klinikaufenthalte nötig.

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Medicated prevention of scarring after glaucoma surgery

Cited by 6 publications

References 34 publications

Intraocular pressure control efficacy and safety of HA-Mg glaucoma drainage plate implantation in the anterior chamber of rabbit eyes

Intraocular pressure control efficacy and safety of HA-Mg glaucoma drainage plate implantation in the anterior chamber of rabbit eyes

Role of the chloride channel blocker in the formation of filtering tract scars after glaucoma surgery in rats

Trabekulektomie mit Mitomycin C und Ologen®-Implantat im Vergleich zur klassischen Trabekulektomie

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