Medicated chewing gum: An unconventional drug delivery system

Abstract

Medicated chewing gum has a history for about a century. Now-a-days it is considered to be a potential and conve-nient modified release drug delivery system which can be used in pain relief medication, smoking cessation, travel illness, freshening of breath, prevention of dental caries, alleviation of xerostomia, vitamin or mineral supplementa-tion etc. Medicated chewing gums are prepared by using a water insoluble gum base with water soluble bulk portion. This formulation offers both local and systemic effects and has a range of advantages over conventional oral solid dosage forms. USP currently has no in vitro release testing apparatus for the evaluation and determination of drug release from the prepared chewing gums. But European Pharmacopoeia adopted a compendial apparatus to do so. Medicated chewing has drawn attention to the researchers as potential drug delivery system and it could be a com-mercial success in near future.Key Words: pharmaceutical chewing gum, gum base, oral mucosal drug delivery, buccal membrane, apparatus.DOI: http://dx.doi.org/10.3329/icpj.v1i4.10064International Current Pharmaceutical Journal 2012, 1(4): 86-91

Formulation and Evaluation of Medicated Chewing Gum Containing Antibacterial Agent.

“…The advantage of buccal route is administration has direct access to systemic circulation. This avoids first pass hepatic metabolism and local loss of the drug at site 1,2 . In the present work non toxic synthetic gum base has been used in the formulation of medicated chewing gum (MCG) containing an antimicrobial agent Chlorhexidine gluconate 3 .…”

Oral Dosages Form: Medicine Containing Chewimg Gum: A Review

“…Chewing gums are taken orally and oral route of drug delivery is the most preferred route amongst the patient and clinicians due to various advantages it offers, in recent years chewing gums are considered to be friendly oral mucosal drug delivery systems 1 . Chewing gum has been used to deliver therapeutic agents such as nicotine for smoking cessation therapy.…”

Potential Use of Cinnamomum burmanii Essential Oil-based Chewing Gum as Oral Antibiofilm Agent

“…Elastomer dan pelarutnya memberikan tekstur permen karet yang kenyal, elastisitas, dan lunak. 27 Biasa digunakan elastomer alami seperti jelutong, Lechi Caspi, Perillo,dan Chicle, atau elastomer sintetik seperti polyisobutylene dan butyl rubber. 26 Plastisizer digunakan untuk mengatur kekompakan atau konsistensi produk, contohnya sorbital monostearate dan propylene glycol monostearate.…”

“…28 Komponen dasar permen karet yang larut dalam air terdiri dari emulsifier, pewarna, perasa, antioksidan, bulking agent, dan compression adjuvant. 27 Emulsifier berfungsi untuk memberikan tekstur yang lembut pada gusi dan jaringan lunak rongga mulut, contohnya gliserin dan lesitin. Pewarna atau pemutih berfungsi untuk memberikan warna yang menarik pada produk, yang dapat diterimaoleh konsumen, contohnya titanium oksida, pewarna makanan dari bahan alami atau buatan yang cocok untuk makanan dan obat.…”

“…Pewarna atau pemutih berfungsi untuk memberikan warna yang menarik pada produk, yang dapat diterimaoleh konsumen, contohnya titanium oksida, pewarna makanan dari bahan alami atau buatan yang cocok untuk makanan dan obat. 27 …”