Medically recorded allergies and the risk of childhood acute lymphoblastic leukaemia

Spector, Logan G.; Groves, Frank D.; DeStefano, Frank; Liff, Jonathan M.; Klein, Mitch; Mullooly, John P.; Black, Steve; Shinefield, Henry R.; Ward, Joel I.; Marcy, Michael

doi:10.1016/j.ejca.2003.08.024

Cited by 47 publications

(61 citation statements)

References 13 publications

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“…However, two studies did find increased odds of childhood ALL associated with atopic diseases. A 2004 US case-control study found a significantly increased odds of childhood ALL associated with atopy (abstracted from medical records of 180 cases) (OR 2.2, 95 % CI 1.2-4.2)[79]. A population-based case-control study in Taiwan used medical claims data and found both asthma (OR…”

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confidence: 99%

Atopy and Specific Cancer Sites: a Review of Epidemiological Studies

Cui

Hill

2016

Clinic Rev Allerg Immunol

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Mounting evidence appears to link asthma and atopy to cancer susceptibility. This review presents and discusses published epidemiological studies on the association between site-specific cancers and atopy. PubMed was searched electronically for publications between 1995 and 2015, and cited references were researched manually. Quantitative studies relating to atopy, allergy, or asthma and cancer were identified and tabulated. Despite many exposure-related limitations, patterns in the studies were observed. Asthma, specifically, has been observed to be a risk factor for lung cancer. A protective effect of atopic diseases against pancreatic cancer has been shown consistently in case-control studies but not in cohort studies. Allergy of any type appears to be protective against glioma and adult acute lymphoblastic leukemia. Most studies on atopic diseases and non-Hodgkin lymphoma or colorectal cancer reported an inverse association. The other sites identified had varying and non-significant outcomes. Further research should be dedicated to carefully defined exposure assessments of "atopy" as well as the biological plausibility in the association between atopic diseases and cancer.

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confidence: 99%

Atopy and Specific Cancer Sites: a Review of Epidemiological Studies

Cui

Hill

2016

Clinic Rev Allerg Immunol

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“…1 Atopy, as a subset of the allergic disorders, has been implicated in the risk of lymphoma, 2-4 leukemia, [5][6][7] brain tumor [8][9][10][11] and pancreatic cancer, 12 and possibly of other solid tumors as well. 13 Results from epidemiological studies have been conflicting, and 2 distinct and contradictory hypotheses have been raised.…”

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confidence: 99%

Atopic diseases, immunoglobulin E and risk of cancer of the prostate, breast, lung and colorectum

Wang

Rothenbacher

Löw

et al. 2006

Intl Journal of Cancer

136

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There is increasing epidemiological evidence for a role of allergic/ atopic disorders in cancer development. However, findings have been inconsistent, which may be partly due to differences in defining allergy and the associated atopic disorders. The use of a biological marker for atopy may enhance the exploration of the association with cancer risks. To examine the association of atopy with common malignancies, we compared the prevalence of atopy in 318 patients with prostate cancer, 381 patients with breast cancer, 196 patients with lung cancer, 477 patients with colorectal cancer and 4,271 controls in a case-control analysis of participants of 2 prospective studies conducted in Saarland, Germany. Data on physician-diagnosed atopy-related diseases (asthma, hay fever and atopic dermatitis) were obtained by self-administered questionnaire. Allergen-specific immunoglobulin E (IgE) was assessed among cases and controls to define atopy. We observed a significantly increased risk of prostate cancer (odds ratio (OR) 1.35, 95% confidence interval (CI) 1.00-1.83) and a tentatively, statistically not significant increased risk of breast cancer (OR 1.20, 95% CI 0.87-1.66) and lung cancer (OR 1.29, 95% CI 0.87-1.92) with specific IgE positivity. No consistent associations were found with atopyrelated diseases. Our findings are consistent with other epidemiological evidence suggesting an increased risk of prostate cancer with atopy and indicate a complex association between atopy/atopyrelated diseases and cancer risk that varies by type of atopy-related disorders and the particular type of cancer under consideration. The effect on cancer risk by atopy, defined by IgE reactivity, may differ from the effect by atopy-related clinically defined diseases such as asthma, hay fever and atopic dermatitis. ' 2006 Wiley-Liss, Inc.

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“…Although the information bias �pp�� b� ��v��b��, �� v�� w�� u�� uk�� NHL (significant in NHL �� non-significant in ALL and AML) was notable, p��v�� p�� likely to pay attention to disease history, �� b�� -positive association (27). The positive association between asthma and the risk of ��v��p�� u�� uk�� NHL w�� p�� p��v��u� studies (17,18). Shared etiologic�� factors may account for the ��u��.…”

Section: Discussionmentioning

confidence: 99%

“…By contrast, �� u�� hypothesis suggest� �� u��-��u�� may p��p�� , �u� �� u�b�� mutations in activated dividing immune cells (9)(10)(11)(12). P��v��u� ��u�� u�� w�� p��v� �� uk�� and lymphoma (13)(14)(15)(16), whereas other studies indicated asthma �� a risk factor (17)(18)(19), or ��p�� no association (20)(21)(22)(23).…”

Section: Introductionunclassified

Association of asthma with the risk of acute leukemia and non-Hodgkin lymphoma

Zhou¹,

Yang²

2015

Molecular and Clinical Oncology

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Medically recorded allergies and the risk of childhood acute lymphoblastic leukaemia

Cited by 47 publications

References 13 publications

Atopy and Specific Cancer Sites: a Review of Epidemiological Studies

Atopy and Specific Cancer Sites: a Review of Epidemiological Studies

Atopic diseases, immunoglobulin E and risk of cancer of the prostate, breast, lung and colorectum

Association of asthma with the risk of acute leukemia and non-Hodgkin lymphoma

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