Medical treatment of osteoradionecrosis of the mandible by PENTOCLO: Preliminary results

Abstract

The PENTOCLO protocol achieved clinical and radiological regression of ORN with, in parallel, a reduction of the indications for major surgery. These preliminary results need to be confirmed by prospective studies comprising quality of life assessment.

Prophylactic use of pentoxifylline and tocopherol in patients who require dental extractions after radiotherapy for cancer of the head and neck

“…Early results have been encouraging. [7][8][9] It can be difficult to avoid the onset of ORN in patients who have had radiotherapy for cancer of the head and neck, as the risk increases throughout life. Obvious triggers include dental extractions, but more subtle events, including denture trauma, dental infection, and the insertion of dental implants, have also been implicated.…”

Tissue repair in osteoradionecrosis using pentoxifylline and tocopherol—report of three cases

“…Clodronate is an oral bisphosphonate used for the treatment of deficiencies in calcium absorption or certain malignancies. Robard et al [30] observed a clinical and radiographic improvement in ORN using the PENTO protocol with clodronate and reported that it reduced pain and improved both food intake and mouth opening. Meanwhile, Rice et al [31], in evaluating ORN treatment options, conclude that for advanced or refractory cases, surgical treatments are the only option.…”

Manejo terapêutico e preventivo da osteorradionecrose: revisão integrativa da literatura

“…5,14,16 Em relação aos cuidados locais, nenhum dos artigos selecionados especificou como esses cuidados foram realizados. Na literatura essa abordagem é diversa, com utilização de digluconato de clorexidina e iodopovidona para limpeza das feridas.…”

“…Os efeitos inibitórios sobre os osteoclastos é 1000 vezes inferior aos outros bisfosfonatos e a concentração utilizada no tratamento da ORN é menor que em outras indicações. 5 As publicações E1 e E4 avaliaram a eficácia do PENTOCLO: associação da pentoxifilina (PTX), tocoferol e clodronato e o E6 não incluiu clodronato por relutância devido à experiência com osteonecrose associada ao bifosfonato. No entanto, as…”