Medical Treatment of Joint Disease

Frisbie, David D.; Johnson, Sherry A.

doi:10.1016/b978-0-323-48420-6.00080-6

Cited by 4 publications

(5 citation statements)

References 106 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…This has been reported previously in papers evaluating the effect of repeated arthrocentesis compared to the effect of injecting local anesthetics 29 or amikacin 30 . The values recorded in this current study are largely consistent with values previously reported 31,32 . All horses had nucleated cell counts comparable to normal values previously established for healthy joints.…”

Section: Discussionsupporting

confidence: 91%

See 1 more Smart Citation

Longitudinal evaluation of fentanyl concentrations in equine plasma and synovial fluid following application of transdermal fentanyl patches over one carpal joint

et al. 2023

View full text Add to dashboard Cite

ObjectiveTo determine if transdermally delivered fentanyl can achieve greater concentrations of fentanyl in synovial fluid when applied over a synovial structure.Study designRandomized, experimental study.AnimalsSix healthy adult horses.MethodsEach horse had two 100 μg/h fentanyl matrix patches applied on the dorsal aspect of one, randomly assigned, carpometacarpal joint (CMCJ) for 48 h. Whole blood and bilateral synovial samples from the intercarpal joint were obtained at 0, 2, 6, 12, 24, 36 and 48 h. Fentanyl concentrations were measured with liquid chromatography–mass spectrometry.ResultsAll subjects achieved detectable concentrations of fentanyl in both plasma and synovial fluid. Time to peak synovial and plasma concentration was 12 h. At 6 h, the synovial concentration in the untreated carpus (0.104 ng/mL ± 0.106) was lower than plasma fentanyl concentrations 0.31 ± 0.27 (p = .036). At 12 h, both treated (0.55 ng/mL ± 0.3) and untreated (0.53 ng/mL ± 0.28) synovial fluid fentanyl concentrations were lower than plasma (0.87 ng/mL ± 0.48) concentrations (p < .001 and p = .001, respectively). Synovial concentrations of fentanyl did not differ between treated and untreated joints (p > 0.608 for all time points).ConclusionApplication of fentanyl matrix patches directly over the CMCJ did not result in increased fentanyl concentrations in the synovial fluid of the treated intercarpal joint in normal horses.Clinical significanceThere is likely no analgesic advantage to placing fentanyl patches directly over the affected joint, as it did not result in increased synovial concentrations at the tested site.

show abstract

Section: Discussionsupporting

confidence: 91%

“…Sample viscosity precluded reporting of protein concentrations on every sample. Of the samples recorded, total protein values were found to be within the reference interval cited for repeated arthrocentesis 31,32 …”

Section: Discussionmentioning

confidence: 80%

Longitudinal evaluation of fentanyl concentrations in equine plasma and synovial fluid following application of transdermal fentanyl patches over one carpal joint

et al. 2023

View full text Add to dashboard Cite

show abstract

“…On the one hand, subchondral bone can disperse loads derived from motion, and it is more deformable in comparison with the cortical bone; on the other hand, with the changes of forces on joints, it can physically adjust its morphology, following Wolff's Law. [ 33 ] The adjustment capability is largely promoted by bone resorption and formation processes related to osteoclastogenesis as well as osteoblastogenesis, separately. The abundant vascularization and innervation inside the subchondral bone are conducive to give comprehensive and extensive local feedback to pathological and physiological changes within the bone.…”

Section: Structure and Properties Of Osteochondral Unitmentioning

confidence: 99%

Innovative Tissue‐Engineered Strategies for Osteochondral Defect Repair and Regeneration: Current Progress and Challenges

Zhou

Gjvm

Malda

et al. 2020

Adv Healthcare Materials

View full text Add to dashboard Cite

Clinical treatments for the repair of osteochondral defects (OCD) are merely palliative, not completely curative, and thus enormously unfulfilled challenges. With the in-depth studies of biology, medicine, materials, and engineering technology, the conception of OCD repair and regeneration should be renewed. During the past decades, many innovative tissue-engineered approaches for repairing and regenerating damaged osteochondral units have been widely explored. Various scaffold-free and scaffold-based strategies, such as monophasic, biphasic, and currently fabricated multiphasic and gradient architectures have been proposed and evaluated. Meanwhile, progenitor cells and tissue-specific cells have also been intensively investigated in vivo as well as ex vivo. Concerning bioactive factors and drugs, they have been combined with scaffolds and/or living cells, and even released in a spatiotemporally controlled manner. Although tremendous progress has been achieved, further research and development (R&D) is needed to convert preclinical outcomes into clinical applications. Here, the osteochondral unit structure, its defect classifications, and diagnosis are summarized. Commonly used clinical reparative techniques, tissue-engineered strategies, emerging 3D-bioprinting technologies, and the status of their clinical applications are discussed. Existing challenges to translation are also discussed and potential solutions for future R&D directions are proposed.

show abstract

“…Hingegen bieten gezielte lokale intraartikuläre Injektionen hohe Effizienz ohne systemische Nebenwirkungen [15]. Jahrzehntelang wurden primär Kortikosteroide wegen ihrer starken entzündungs-und schmerzhemmenden und damit lahmheitslindernden Wirkung eingesetzt.…”

Section: Therapieoptionenunclassified

Diagnose und Therapie von Kniegelenkerkrankungen – ein Update

Waselau¹

2021

pferde spiegel

View full text Add to dashboard Cite

Medical Treatment of Joint Disease

Cited by 4 publications

References 106 publications

Longitudinal evaluation of fentanyl concentrations in equine plasma and synovial fluid following application of transdermal fentanyl patches over one carpal joint

Longitudinal evaluation of fentanyl concentrations in equine plasma and synovial fluid following application of transdermal fentanyl patches over one carpal joint

Innovative Tissue‐Engineered Strategies for Osteochondral Defect Repair and Regeneration: Current Progress and Challenges

Diagnose und Therapie von Kniegelenkerkrankungen – ein Update

Contact Info

Product

Resources

About