“…However, in the past two decades, the use of topical medications for OSSN treatment has increased for being an effective alternative to surgical excision. When selecting a topical agent, interferon alpha-2b (IFNα-2b) and 5-fluorouracil (5-FU) are often considered first line therapies for OSSN due to their high-resolution rates and mild side effect profiles [ 13 ].…”