Medical therapies causing iatrogenic male infertility

Velez, Danielle; Ohlander, Samuel

doi:10.1016/j.fertnstert.2021.07.1202

Cited by 8 publications

(7 citation statements)

References 56 publications

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“…Sperm cells can be inadvertently damaged during chemotherapy or radiation therapy, causing these cancer treatments to result in severely low sperm counts or azoospermia, which may or may not rebound. 15,16 It is crucial that a male patient receive fertility preservation counseling prior to undergoing any gonadotoxic treatment. 2 Exogenous testosterone, taken by some men as a nutrition supplement, suppresses pituitary secretion of luteinizing hormone (LH) and follicle-stimulating hormone (FSH) with a resultant decrease in testosterone production within the testicles and thus spermatogenesis.…”

Section: Acquired Causesmentioning

confidence: 99%

“…Other medication classes known to contribute to iatrogenic male infertility include opioids, selective serotonin reuptake inhibitors, and 5-alpha reductase inhibitors. 15 For transgender women who desire medical gender-affirming therapy, androgen deprivation can be used to lessen endogenous testosterone levels, thereby reducing the appearance of male secondary It is crucial that a male patient receive fertility preservation counseling prior to undergoing any gonadotoxic treatment.…”

Section: Acquired Causesmentioning

confidence: 99%

“…Although it allows transgender women to achieve their desired body image, this approach risks loss of reproductive potential, making it important to counsel these patients on fertility preservation options prior to undergoing medical (or surgical) gender-affirming treatments. 15 Sexual dysfunction is an important acquired cause of male infertility and can present as erectile dysfunction, ejaculatory dysfunction, low libido, or a combination of factors. 8 Because proper functioning of the male reproductive system is a necessary component for fertility, evaluation and treatment of sexual dysfunction are of great importance.…”

Section: Acquired Causesmentioning

confidence: 99%

See 2 more Smart Citations

The WHNP’s guide to evaluating male infertility

Rapp¹

2023

WHC

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Section: Acquired Causesmentioning

confidence: 99%

Section: Acquired Causesmentioning

confidence: 99%

Section: Acquired Causesmentioning

confidence: 99%

See 1 more Smart Citation

The WHNP’s guide to evaluating male infertility

Rapp¹

2023

WHC

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“…In fact, in the management of infertile couples, the potential negative impact on seminal parameters of any drugs taken by patients should be considered [ 6 ]. In this regard, chemo- and radio-therapy certainly affect semen parameters; the damage to spermatogenesis is dependent on the dose received and the age of the patient [ 7 , 8 ].…”

Section: Introductionmentioning

confidence: 99%

“…In addition, several studies have shown that the intake of psychotropic drugs can determine alteration of semen quality, mainly a significant impairment of progressive motility and sperm morphology [ 9 ]. Finally, androgens, anti-androgens, and opioids have also been linked with male infertility [ 8 ].…”

Section: Introductionmentioning

confidence: 99%

The effects of non-andrological medications on erectile dysfunction: a large single-center retrospective study

Mazzilli

Zamponi

Mangini

et al. 2023

J Endocrinol Invest

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Purpose To evaluate the association among andrological diseases at the first outpatient visit and the medications taken by patients for other comorbidities, as well as the differential impact between specific medication and relative comorbidities. Methods This is a single-center retrospective study based on subjects who referred to the Andrology Unit with a well-defined andrological diagnosis. Results A total of 3752 subjects were studied (mean age ± DS 46.2 ± 16.5 years). A total of 19 categories of andrological diseases and 110 type of medications for other comorbidities were identified. ED was the most frequent andrological pathology at the first andrological examination (28.7%), followed by infertility (12.4%). The couple of variables that were statistically significant in the univariate association analysis (p < 0.001) were: ED and (a) antihypertensives; (b) antihyperglycemics; (c) lipids-lowering; (d) psychotropics. The univariate and multivariate regression analyses confirmed the association. All the related comorbidities were also significantly associated with the univariate analysis, and all remained significantly associated with multivariate analysis. A multivariate analysis was also conducted to analyze the association between ED and the following pairs of variables “DM-antihyperglycemics”, “dyslipidemia-lipids-lowering”, and “hypertension-antihypertensives”. In all cases, the pathology, but not the specific treatment, was significantly associated with ED. Conclusion ED is significantly associated with antihypertensive, antihyperglycemic, lipid-lowering, psychotropic drugs’ intake. Anyway, ED appears to be more related to the diseases than to the specific therapies. The definitive cause/effect relationship should be established based on future prospective studies.

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Lycopene protects against ionizing radiation‐induced testicular damage by inhibition of apoptosis and mitochondrial dysfunction

Qu,

He,

Guo

2023

Food Science & Nutrition

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Ionizing radiation (IR) is one of the key contributors that cause male infertility by disturbing spermatogenesis. Lycopene, a carotenoid with strong antioxidant properties, was shown to protect against oxidative damage induced by IR in several experimental models. The present study was designed to explore the possible protective effects of lycopene against IR‐induced testicular damage in C57BL/6 mice. Mice were administered lycopene (20 mg/kg) by oral gavage for seven consecutive days prior to a single dose of whole‐body X‐ray irradiation (4 Gy, 1 Gy/min). We observed that lycopene remarkably augmented sperm motility and reduced sperm abnormalities in mice following IR exposure. Histopathological analyses also revealed that lycopene ameliorated the structural damage of seminiferous tubules and enhanced the regeneration of seminiferous epithelium following IR stress. Moreover, lycopene attenuated IR‐induced oxidative stress, as evidenced by a decreasing lipid peroxidation level and an increase in the antioxidant enzyme superoxide dismutase activity. In addition, lycopene reduced the γH2AX expression and the number of TUNEL‐positive cells in the germinal epithelium, as well as restoring the imbalance of Bax/Bcl‐2 expression induced by IR exposure. Furthermore, lycopene prevented mitochondrial membrane potential depolarization and ATP reduction and preserved the activities of mitochondrial complexes I‐IV in the testes of mice after exposure to IR. Lycopene also improved mitochondrial biogenesis in testes of mice exposed to IR, presenting as restored expressions of PGC‐1α, Nrf1, and Tfam. Taken together, our results suggest that lycopene alleviates IR‐induced testicular damage, and the underlying mechanism involves at least in part the inhibition of the mitochondrial apoptotic pathway and the maintenance of mitochondrial respiration and biogenesis. The beneficial effect of lycopene highlights the therapeutic potential of this plant‐derived antioxidant against impaired spermatogenesis and male infertility induced by IR.

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Medical therapies causing iatrogenic male infertility

Cited by 8 publications

References 56 publications

The WHNP’s guide to evaluating male infertility

The WHNP’s guide to evaluating male infertility

The effects of non-andrological medications on erectile dysfunction: a large single-center retrospective study

Lycopene protects against ionizing radiation‐induced testicular damage by inhibition of apoptosis and mitochondrial dysfunction

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