Medical Presentations of Choriocarcinoma

Primary nongestational choriocarcinoma of the ovary

“…Overt bleeding from metastases may occur in the gastrointestinal tract, kidney, brain or lung and pulmonary manifestations are the most frequent presenting symptoms of choriocarcinoma (Magrath et al, 1971). Bilateral spontaneous pneumothorax as the presenting symptom of nongestational choriocarcinoma of the ovary has been also reported (Stevens et al, 1979).…”

Primary Choriocarcinoma of the Lung:Presentation of a Case and Review of the Literature

“…A positive HCG test in patients with haemoptysis and progressive dyspnoea, possibly combined with gynecomastia, should arouse the suspicion of pulmonary choriocarcinoma and can thus lead to early diagnosis (13). A positive HCG test in patients with haemoptysis and progressive dyspnoea, possibly combined with gynecomastia, should arouse the suspicion of pulmonary choriocarcinoma and can thus lead to early diagnosis (13).…”

Radiological Changes in the Chest in Malignant Trophoblastic Disease

“…However, the encouraging results of chemotherapy have underlined the importance of correct diagnosis, even in these advanced cases. It has also been shown that treatment is more likely to be effective when the disease is detected as soon as possible after the antecedent pregnancy (Tow, 1965;Magrath et al, 1971). Because of the high frequency of intrathoracic spread, an awareness of the varied radiological changes in the chest should contribute to earlier diagnosis and treatment.…”

“…When overt pelvic disease is present, the clinical diagnosis is usually obvious, and this can be confirmed by histological examination of curettage or operative specimens. However, many patients present not with gynaecological symptoms but with metastatic manifestations in locations other than the genital tract (Magrath, Golding and Bagshawe, 1971). The chest is a common site of such metastases.…”