Medical Laboratory Automation Using Robotics

Severns, Matthew L.; Hawk, Gerald L.

doi:10.1007/978-3-642-82153-0_33

Cited by 9 publications

(3 citation statements)

References 4 publications

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“…The utility of a unit operations approach is perhaps best demonstrated by laboratory robot systems (Severns & Hawk, 1984). In these robot systems, general purpose workstations like solid phase extraction or reaction vessel heating surround a central manipulator arm which can be programmed to execute unique sequences of steps to create a specific automated process like a radiotracer synthesis.…”

Section: Unit Operations Designmentioning

confidence: 99%

Automation for the Synthesis and Application of PET Radiopharmaceuticals

Alexoff

2002

Handbook of Radiopharmaceuticals

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These unique constraints include short synthesis (often limited to20r3 half-lives) times and control from behind bulky shielding structures that make both access to, and visibility of, radiochemical processes and equipment difficult. Often Curie levels of positron emitting nuclides are required for synthesis of PET radiopharmaceuticals, making this potentially dangerous for a radiochemist or laboratory specialist. The use of short half-lived radionuclides also necessitates that many PET radiotracers (particularly those labeled with 1lC, *3N, and '50) be synthesized repetitively during the day, each dose being produced separately just before administration.Radiotracer synthesis must be reliable and efficient to keep the costs of PET procedures down. Furthermore, radiotracer synthesis procedures for human use must produce pharmaceutical quality products and be well documented and controlled to help satisfy requirements of federal and local regulations on human research.Automation can help PET research institutions overcome all of these potential '" limitations. A look at the history of the development of successful automated PET radiotracer synthesis machines reveals a richness in engineering solutions to these problems that still exists today.

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Section: Unit Operations Designmentioning

confidence: 99%

Automation for the Synthesis and Application of PET Radiopharmaceuticals

Alexoff

2002

Handbook of Radiopharmaceuticals

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“…One method to further automate laboratory tasks is to use robots to prepare samples for these instruments or to move samples between instruments. Most laboratory tasks can be brok en down into a series of basic operations, called Labora tory Unit Operations [2], These operations include manipulation, liquid handling, separation, pulverization, measurement, conditioning and data management. Of these operations, manipulation and liquid handling can be handled by a robot, while the rest are performed by specialized equipment which is interfaced to the robot's controller.…”

Section: Robots For General Laboratory Usementioning

confidence: 99%

“…Severns and Hawk [2] and Brennan and Severns [6] have described how the Zymate was used to automate the sample handling aspects of microplate-based blood grouping. For each centrifuged blood sample, the objec tive was to aspirate and dispense plasma into specific microplate wells and aspirate, dilute and dispense red cells into others.…”

Section: Sample Preparation For Abo/rh Testingmentioning

confidence: 99%

Application of Robotics in Blood Banking

Friedman¹,

Severns²

1986

Vox Sanguinis

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To demonstrate the feasibility of using robots in blood banking applications several prototype systems were developed. Activities associated with sample testing and component preparation were examined. In one project, a general-purpose laboratory robot (Zymate Laboratory Automation System, Zymark, Inc., Hopkinton, Mass.) was configured to prepare samples for microplate-based ABO/Rh testing. In a second project, this same robot was configured to carry out specific steps in evaluating bar-coded labels, as part of a quality control procedure. A fluid-handling robot (Sampler 505, Tecan AG, Hombrechtikon, Switzerland) was used to prepare the dilution of serum samples for the evaluation of an anti-HTLV-III test kit. It was then configured to aspirate, dilute and dispense samples for anti-HTLV-III and HBsAg testing. This robotic system is now in field trial. The use of large industrial robots for automating component production was also considered. The key element in this design was the development of a fixture that would hold the blood bag set during the balancing, centrifugation and expressing steps. However, a fixture which was capable of performing these operations and that was equivalent in size and adaptable to a standard centrifuge bucket could not be fabricated.

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Application of Robotics in Blood Banking

Friedman¹,

Severns²

1986

Future Developments in Blood Banking

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Medical Laboratory Automation Using Robotics

Cited by 9 publications

References 4 publications

Automation for the Synthesis and Application of PET Radiopharmaceuticals

Automation for the Synthesis and Application of PET Radiopharmaceuticals

Application of Robotics in Blood Banking

Application of Robotics in Blood Banking

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