Medical interventions for the prevention of platinum-induced hearing loss in children with cancer

As, Jorrit W van; Berg, Henk van den; Dalen, Elvira C. van

doi:10.1002/14651858.cd009219

Cited by 3 publications

(1 citation statement)

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“…During chemotherapy, sensory symptoms were more pronounced in the hands than in the feet, however, by 18 months, sensory symptoms were more intense in the feet as compared to the hands [21]. Progressive and unstoppable hearing loss and tinnitus are typical side effects of platinum-based chemotherapy in children, and they occur more frequently with cisplatin (60% of children) than with oxaliplatin [22]. Oxaliplatin is unusual in that it causes acute neurotoxicity in the form of cold-induced dysesthesias.…”

Section: Symptoms Of Platinum Induced Neuropathymentioning

confidence: 99%

Prevention and Management of Platinum Compounds-Induced Neurotoxicity

Marouf

Ali²

2021

Al-Rafidain J Med Sci

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Oncologists considered platinum-based medicines as potent cytotoxic agents. Despite their efficacy in combination chemotherapy regimens for many solid tumors, they have many substantial side effects that limit their use. There is no known prophylactic strategy for platinum drugs-induced neurotoxicity, which limit a therapeutic dose benefit. This review highlights the etiology of platinum-drugs-induced neuropathy, and covers the preventative and therapeutic options for cancer patients. It focuses on clinical studies conducted between 2010 and 2020. Loss of functional indications such as touch, vibration and joint location, as well as diminished or missing deep tendon reflexes in the upper and lower limbs are all markers of neurotoxicity. These side effects may last for months or years after treatment, lower quality of life, and creating a substantial survivorship issue. DNA damage, oxidative stress, mitochondrial dysfunction, dysregulation of intracellular signaling, impairment of voltage gated ion channel function, and neuro-inflammation have all been proposed as mechanisms for chemotherapy-induced peripheral neuropathy (CIPN). There are no proven pharmaceutical or nutritional therapies to prevent CIPN. Several anti-CIPN medications have been investigated, but either had no effect or had an effect in a limited sample study. Supportive care medications such anti-epileptics and antidepressants are used to treat CIPN.

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Section: Symptoms Of Platinum Induced Neuropathymentioning

confidence: 99%