Medical interventions for the prevention of platinum-induced hearing loss in children with cancer

As, Jorrit W van; Berg, Henk van den; Dalen, Elvira C. van

doi:10.1002/14651858.cd009219.pub4

Cited by 37 publications

(13 citation statements)

References 46 publications

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“…Another antioxidant, amifostine, significantly reduced cisplatin-induced serious hearing loss in patients with average-risk medulloblastoma (Fouladi et al, 2008;Gurney et al, 2014). Some trials have had contradictory results (Yoo et al, 2014;van As et al, 2016) or protective failure, (Fox et al, 2018), attributed to the difference in drug dosage and timing for administration prior to cisplatin treatment, which might decrease the potential maximal protective effect of the same drug. Therefore, a larger scale research, employing various concentrations to be delivered in precise timing, is required.…”

Section: Clinical Trialsmentioning

confidence: 99%

Current Strategies to Combat Cisplatin-Induced Ototoxicity

Chen

et al. 2020

Front. Pharmacol.

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Cisplatin is widely used for the treatment of a number of solid malignant tumors. However, ototoxicity induced by cisplatin is an obstacle to effective treatment of tumors. The basis for this toxicity has not been fully elucidated. It is generally accepted that hearing loss is due to excessive production of reactive oxygen species by cells of the cochlea. In addition, recent data suggest that inflammation may trigger inner ear cell death through endoplasmic reticulum stress, autophagy, and necroptosis, which induce apoptosis. Strategies have been extensively explored by which to prevent, alleviate, and treat cisplatin-induced ototoxicity, which minimize interference with antitumor activity. Of these strategies, none have been approved by the Federal Drug Administration, although several preclinical studies have been promising. This review highlights recent strategies that reduce cisplatin-induced ototoxicity. The focus of this review is to identify candidate agents as novel molecular targets, drug administration routes, delivery systems, and dosage schedules. Animal models of cisplatin ototoxicity are described that have been used to evaluate drug efficacy and side effect prevention. Finally, clinical reports of otoprotection in patients treated with cisplatin are highlighted. For the future, high-quality studies are required to provide reliable data regarding the safety and effectiveness of pharmacological interventions that reduce cisplatin-induced ototoxicity.

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Section: Clinical Trialsmentioning

confidence: 99%

Current Strategies to Combat Cisplatin-Induced Ototoxicity

Chen

et al. 2020

Front. Pharmacol.

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“…Nefrotoksisite, nötropeni ve kserostomiyi engellediği kanıtlanmış olsa da otoprotektif etkisi net değildir. Hepatoblastom, germ hücreli tümör, medulloblastom gibi sisplatin içeren rejimlerin kullanıldığı çocuklarda eşzamanlı amifostin kullanımının koruyucu etkisi ile ilşkili klinik çalışmalar yapılmıştır ama otoprotektif etki çoğunda kanıtlanamamıştır (2,6,20) .…”

Section: Ototoksisitenin öNlenmesiunclassified

Approach to Treatment Related Ototoxicity in Children

Kızmazoğlu¹,

Olgun²,

Ince³

2019

TERH

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Ototoksisite; bir ilaç veya kimyasalın iç kulak fonksiyonlarını olumsuz yönde etkileyerek işitme-denge bozukluğuna yol açmasıdır. Klinik bulguları; işitme kaybı, kulak çınlaması ve/veya vertigodur. Platinum grubu kemoterapötikler, loop grubu diüretikler, aminoglikozid grubu antibiyotikler ototoksisiteye en sık neden olan ilaçlarken, radyoterapi ve cerrahi de işitme kaybı ilişkili olabilecek diğer tedavi yöntemleridir. Ototoksisite gelişiminde genetik predispozisyonun önemi de büyüktür. En önemli önleyici yöntem, ototoksisiteye neden olabilecek tedavi alan hastalarda aralıklı işitme testi ile işitme fonksiyonunun değerlendirilmesidir. Ototoksisitenin erken tespitinin sağlanması ile koruyucu ve tedavi edici önlemler alınarak işitme kaybı nedenli akademik, dil, konuşma, sosyal ve psikososyal morbidite azaltılabilir.

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“…Currently, models are being created to study for therapeutics for cisplatin-induced hearing loss ( Callejo et al., 2017 , Wu et al., 2017 ). Many studies target possible therapeutic drugs for platinum-induced hearing loss ( Theunissen et al., 2015 , van As et al., 2016a , van As et al., 2016b ).…”

Section: Hair Cell Lossmentioning

confidence: 99%

Apoptosis in inner ear sensory hair cells

Morrill

2017

Journal of Otology

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Apoptosis, or controlled cell death, is a normal part of cellular lifespan. Cell death of cochlear hair cells causes deafness; an apoptotic process that is not well understood. Worldwide, 1.3 billion humans suffer some form of hearing loss, while 360 million suffer debilitating hearing loss as a direct result of the absence of these cochlear hair cells (Worldwide Hearing, 2014). Much is known about apoptosis in other systems and in other cell types thanks to studies done since the mid-20th century. Here we review current literature on apoptosis in general, and causes of deafness and cochlear hair cells loss as a result of apoptosis. The family of B-cell lymphoma (Bcl) proteins are among the most studied and characterized. We will review current literature on the Bcl2 and Bcl6 protein interactions in relation to apoptosis and their possible roles in vulnerability and survival of cochlear hair cells.

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Medical interventions for the prevention of platinum-induced hearing loss in children with cancer

Abstract: Medical interventions for the prevention of platinum-induced hearing loss in children with cancer.

Cited by 37 publications

References 46 publications

Current Strategies to Combat Cisplatin-Induced Ototoxicity

Current Strategies to Combat Cisplatin-Induced Ototoxicity

Approach to Treatment Related Ototoxicity in Children

Apoptosis in inner ear sensory hair cells

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