Medical Cannabis in Children

Aran, Adi; Cayam-Rand, Dalit

doi:10.5041/rmmj.10386

Cited by 31 publications

(34 citation statements)

References 117 publications

(98 reference statements)

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“…Progress in the patients’ autonomy, increased motor, and cognitive performances as well as communication and social interaction improvements were also reported. The expected anticonvulsant effect of CBD ( Mullard, 2018 ; Silvestro et al, 2019 ; Alves et al, 2020 ; Aran and Cayam-Rand, 2020 ; Lazarini-Lopes et al, 2020 ) was confirmed in two studies in which seizures were at least partially or even completely controlled ( Bar-Lev Schleider et al, 2019 ; Fleury-Teixeira et al, 2019 ). In accordance with these studies, a recent case report about a 15-year-old boy with ASD who was treated with CBD-enriched cannabis extract oil (CBD/THC ratio of 20:1; 4 mg CBD and 0.2 mg THC twice a day) reported that CBD-based treatment aided in the control of ASD-related behavioral symptoms, core social communication abilities, anxiety, sleep difficulties, and body weight ( Ponton et al, 2020 ).…”

Section: Reviewed Studies On Autism Spectrum Disordermentioning

confidence: 81%

Is Cannabidiol During Neurodevelopment a Promising Therapy for Schizophrenia and Autism Spectrum Disorders?

et al. 2021

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Schizophrenia and autism spectrum disorders (ASD) are psychiatric neurodevelopmental disorders that cause high levels of functional disabilities. Also, the currently available therapies for these disorders are limited. Therefore, the search for treatments that could be beneficial for the altered course of the neurodevelopment associated with these disorders is paramount. Preclinical and clinical evidence points to cannabidiol (CBD) as a promising strategy. In this review, we discuss clinical and preclinical studies on schizophrenia and ASD investigating the behavioral, molecular, and functional effects of chronic treatment with CBD (and with cannabidivarin for ASD) during neurodevelopment. In summary, the results point to CBD's beneficial potential for the progression of these disorders supporting further investigations to strengthen its use.

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Section: Reviewed Studies On Autism Spectrum Disordermentioning

confidence: 81%

Is Cannabidiol During Neurodevelopment a Promising Therapy for Schizophrenia and Autism Spectrum Disorders?

et al. 2021

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“…Research suggests that CBD may also interact with benzodiazepines. It has been noted that the active metabolites of benzodiazepines increase significantly with concurrent use of CBD and CBD-rich medical marijuana [26].…”

Section: Drug Interactionsmentioning

confidence: 99%

Epilepsy and cannabidiol - a new perspective for seizures treatment

Kozioł

Budzyńska

Leśniewska

et al. 2021

J Educ Health Sport

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BACKGROUND: Despite the fact that the number of antiepileptic drugs is constantly increasing, epilepsy can still be a therapeutic challenge. Approximately one-third of patients with epilepsy have persistent seizures refractory to treatment. The limited number of effective alternatives motivates researchers to seek new solutions. There is some hope for cannabidiol (CBD) preparations.AIM OF THE STUDY: The purpose of this study was to review the most recent available literature on the use of cannabidiol in the treatment of refractory epilepsy in children and adults. For this purpose, the PubMed and Google Scholar databases were reviewed. The phrase "cannabidiol and epilepsy" was used to search the database. After Screening titles and abstracts a total of 19 papers and articles cited in them were received and analyzed in detail. RESULTS: Nowadays there are many CBD related products available in the market, Cannabis sativa and Cannabis indica are the plants used due to their strong therapeutic effects and also seizure control. Regulations regarding the use of raw marijuana, cannabis extracts, and cannabinoid-based drugs vary from place to place. Many studies have been generated on the efficacy of cannabinoid therapy in the treatment of epilepsy. This therapy in patients with Dravet syndrome and Lennox-Gaust syndrome results in a reduction in the frequency of motor and total seizures. The most commonly reported side effects of CBD are drowsiness, seizures and diarrhea, but the therapy is generally well tolerated.SUMMARY AND CONCLUSIONS: Many available studies support the efficacy of CBD as a treatment option to reduce seizure frequency in children with drug-resistant epilepsy, particularly in patients with Dravet and Lennox-Gastaut syndrome. However, there is a lack of reports on the use of CBD in the adult population, which may be an area for further research.

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“…Of those 19, ten articles were literature reviews regarding the treatment of autism with cannabis derived products. [2][3][4][5][6][7][8][9][10][11] The remaining nine articles consisted of a viewpoint, ethics statement, letter, two studies done on adult populations, and four studies done using cannabis-based products for the treatment of autism related symptoms in children. [12][13][14][15][16][17][18][19][20] The 2019 Schleider et al article was about a prospective study looking at the safety and efficacy of medical cannabis treatment in children with ASD.…”

Section: Related Literaturementioning

confidence: 99%

Little is known about cannabidiol for improving severe behavioral symptoms of autistic spectrum disorder

Mishra

2020

Clin. Res. Pract.

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Medical Cannabis in Children

Abstract: Conflict of interest: Adi Aran reports receiving personal fees and stock options for advisory roles at BOL Pharma. No potential conflict of interest relevant to this article was reported for Dalit Cayam-Rand.

Cited by 31 publications

References 117 publications

Is Cannabidiol During Neurodevelopment a Promising Therapy for Schizophrenia and Autism Spectrum Disorders?

Is Cannabidiol During Neurodevelopment a Promising Therapy for Schizophrenia and Autism Spectrum Disorders?

Epilepsy and cannabidiol - a new perspective for seizures treatment

Little is known about cannabidiol for improving severe behavioral symptoms of autistic spectrum disorder

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