Medical applications of biopolymer nanofibers

Jeevanandam, Jaison; Pan, Sharadwata; Rodrigues, João; Elkodous, M. Abd; Danquah, Michael K.

doi:10.1039/d2bm00701k

Cited by 18 publications

(11 citation statements)

References 112 publications

(125 reference statements)

Supporting

Mentioning

Contrasting

Order By: Relevance

“…In the last decade, nanocarriers like micelles, liposomes, nanofibers, and polymeric nanoparticles have been extensively investigated as potential delivery systems for diagnostic and/or therapeutic agents [ 1 , 2 , 3 , 4 , 5 , 6 ]. Thanks to their size (diameter of 10–500 nm), nanoparticles display some unique pharmacokinetic features, including rapid clearance via the reticuloendothelial system (RES) and preferential extravasation and accumulation at the site of solid tumors [ 7 ].…”

Section: Introductionmentioning

confidence: 99%

Caveolin-Mediated Internalization of Fmoc-FF Nanogels in Breast Cancer Cell Lines

Smaldone¹,

Rosa

Gallo³

et al. 2023

Pharmaceutics

View full text Add to dashboard Cite

Introduction: Hydrogel nanoparticles, also known as nanogels (NGs), have been recently proposed as alternative supramolecular vehicles for the delivery of biologically relevant molecules like anticancer drugs and contrast agents. The inner compartment of peptide based NGs can be opportunely modified according to the chemical features of the cargo, thus improving its loading and release. A full understanding of the intracellular mechanism involved in nanogel uptake by cancer cells and tissues would further contribute to the potential diagnostic and clinical applications of these nanocarriers, allowing the fine tuning of their selectivity, potency, and activity. The structural characterization of nanogels were assessed by Dynamic Light Scattering (DLS) and Nanoparticles Tracking Analysis (NTA) analysis. Cells viability of Fmoc-FF nanogels was evaluated by MTT assay on six breast cancer cell lines at different incubation times (24, 48, and 72 h) and peptide concentrations (in the range 6.25 × 10−4 ÷ 5·10−3 × wt%). The cell cycle and mechanisms involved in Fmoc-FF nanogels intracellular uptake were evaluated using flow cytometry and confocal analysis, respectively. Fmoc-FF nanogels, endowed with a diameter of ~130 nm and a zeta potential of ~−20.0/−25.0 mV, enter cancer cells via caveolae, mostly those responsible for albumin uptake. The specificity of the machinery used by Fmoc-FF nanogels confers a selectivity toward cancer cell lines overexpressing the protein caveolin1 and efficiently performing caveolae-mediated endocytosis.

show abstract

Section: Introductionmentioning

confidence: 99%

Caveolin-Mediated Internalization of Fmoc-FF Nanogels in Breast Cancer Cell Lines

Smaldone¹,

Rosa

Gallo³

et al. 2023

Pharmaceutics

View full text Add to dashboard Cite

show abstract

“…It is a well-known fact that biopolymers are promising building blocks for preparing materials with excellent performance due to their high efficiency, sustainability, and environmental friendliness. Polymers isolated from plant sources such as polysaccharides (cellulose, starch, chitin, and chitosan) have been used for the fabrication of composite membranes [ 8 , 9 ]. Biomaterials derived from biopolymers have received much attention for a variety of industrial and biomedical applications, including biofluid and water purification [ 10 , 11 ].…”

Section: Introductionmentioning

confidence: 99%

Fabrication and Characterization of Functional Biobased Membranes from Postconsumer Cotton Fabrics and Palm Waste for the Removal of Dyes

Khan

Karim

Charnnok

et al. 2023

IJMS

View full text Add to dashboard Cite

Textile industries currently face vast challenges for the active removal of colored wastewater. Indeed, sustainable, recyclable, and green approaches are still lacking to achieve this aim. Thus, the present study explored the utilization of highly functional, green, recyclable, fully bio-based, and cost-effective composite membranes from post-consumer cotton fabrics and palm waste for wastewater treatment purposes. Highly functional cellulose nanofibers (CNF) were produced from waste cotton fabrics and filter paper using an acid hydrolysis technique. The yield of nanofibers extracted from waste cotton fabrics and filter paper was 76.74 and 54.50%, respectively. The physical, chemical, and structural properties of nanofibers were studied using various advanced analytical techniques. The properties of isolated nanofibers were almost similar and comparable to those of commercial nanofibers. The surface charge densities were −94.0, −80.7, and −90.6 mV for the nanofibers of palm waste, cotton fibers, and filter paper, respectively. After membrane fabrication using vacuum and hot-pressing techniques, the characteristics of the membrane were analyzed. The results showed that the average pore size of the palm-waste membrane was 1.185 nm, while it was 1.875 nm for membrane from waste cotton fibers and filter paper. Congo red and methylene blue dyes were used as model solutions to understand the behavior of available functional groups and the surface ζ-potential of the membrane frameworks’ interaction. The membrane made from palm waste had the highest dye removal efficiency, and it was 23% for Congo red and 44% for methylene blue. This study provides insights into the challenges associated with the use of postconsumer textile and agricultural waste, which can be potentially used in high-performance liquid filtration devices for a more sustainable society.

show abstract

“…1). The biphasic MNP, comprising biocompatible hydrophilic PVP 24,25 microneedles and a hydrophobic PS base, 26,27 demonstrated a superior drug loading capacity and enabled invisible drug delivery through a rapid separation. Next, we used a contraceptive hormone (levonorgestrel (LNG)) as a model drug to verify the feasibility of the system, considering that patients tend to adjust the dosing frequency according to intention and the duration of contraception.…”

Section: Introductionmentioning

confidence: 99%

Personalized demand-responsive biphasic microneedle patch for smart drug administration

Deng¹,

Yao²,

Zhang³

et al. 2023

Biomater. Sci.

View full text Add to dashboard Cite

show abstract

Medical applications of biopolymer nanofibers

Abstract: A wide array of biomedical applications, extending from the fabrication of implant materials to targeted drug delivery, can be attributed to polymers. The utilization of chemical monomers, to form polymers,...

Cited by 18 publications

References 112 publications

Caveolin-Mediated Internalization of Fmoc-FF Nanogels in Breast Cancer Cell Lines

Caveolin-Mediated Internalization of Fmoc-FF Nanogels in Breast Cancer Cell Lines

Fabrication and Characterization of Functional Biobased Membranes from Postconsumer Cotton Fabrics and Palm Waste for the Removal of Dyes

Personalized demand-responsive biphasic microneedle patch for smart drug administration

Contact Info

Product

Resources

About