Psoriasis is a chronic and recurrent skin disease that often requires long‐term treatment, and topical transdermal drug delivery can reduce systemic side effects. However, it is still a challenge in efficient transdermal drug delivery for psoriasis treatment due to low penetration efficiency of most drugs and the abnormal skin conditions of psoriasis patients. Here, a safe and effective methacryloyl chitosan hydrogel microneedles (CSMA hMNs) patch is developed and served as a sustained drug release platform for the treatment of psoriasis. By systematically optimizing the CSMA preparation, CSMA hMNs with excellent morphological characteristics and strong mechanical properties (0.7 N needle−1) are prepared with a concentration of only 3% (w/v) CSMA. As a proof‐of‐concept, methotrexate (MTX) and nicotinamide (NIC) are loaded into CSMA hMNs patch, which can produce a sustained drug release of 80% within 24 h in vitro. In vivo experiments demonstrated that the CSMA hMNs patch can effectively inhibit the skin thickening and spleen enlargement of psoriatic mice and has a good biosafety profile at sufficient therapeutic doses. This study provides a new idea for the preparation of hMN systems using modified CS or other biocompatible materials and offers an effective therapeutic option for psoriasis treatment.This article is protected by copyright. All rights reserved
The healing of biofilm‐infected diabetic wounds characterized by a deteriorative tissue microenvironment represents a substantial clinical challenge. Current treatments remain unsatisfactory due to the limited antibiofilm efficacy caused by weak tissue and biofilm permeability of drugs and the risk of reinfection during the healing process. To address these issues, an integrated therapeutic and preventive nanozyme‐based microneedle (denoted as Fe2C/GOx@MNs) is engineered. The dissolvable tips with enough mechanical strength can deliver and rapidly release Fe2C nanoparticles (NPs)/glucose oxidase (GOx) in the biofilm active regions, enhancing tissue and biofilm permeability of Fe2C NPs/GOx, ultimately achieving highly efficient biofilm elimination. Meanwhile, the chitosan backing layer can not only act as an excellent physical barrier between the wound bed and the external environment, but also prevent the bacterial reinvasion during wound healing with its superior antibacterial property. Significantly, the biofilm elimination and reinfection prevention abilities of Fe2C/GOx@MNs on wound healing are proved on methicillin‐resistant Staphylococcus aureus‐biofilm‐infected diabetic mouse model with full‐thickness wound. Together, these results demonstrate the promising clinical application of Fe2C/GOx@MNs in biofilm‐infected wound healing.
Many patients, especially those with chronic diseases, always need personalized drugs that could modulate treatment regimen. Tailored drug delivery via microneedle patches (MNPs) has emerged as a promising technology to...
Antimicrobial resistance has brought great burden to global public health. Alternative strategies are needed to reduce the development of drug resistance. Herein, we have developed an effective synergistic antibacterial strategy combining low−temperature photothermal therapy (LT−PTT) with antibiotic therapy, improving the bactericidal efficiency to avoid antimicrobial resistance. Copper sulfide templated with bovine serum albumin (CuS−BSA) nanoparticles were selected as the photothermal agent, and co−loaded into the hydrogel (Gel) with mupirocin. The Gel could slow down the release rate of CuS−BSA and mupirocin, thereby prolonging the effective drug reaction time. More importantly, when applying near−infrared laser irradiation, the antibacterial activity of the platform could be enhanced greatly by LT−PTT effect of CuS−BSA nanoparticles. In vitro and in vivo results both confirmed that the antibacterial efficacy of the synergistic therapeutic strategy was improved greatly with complete bacterial removal. Overall, this platform has posed a potential strategy to reduce the development of drug resistance and improve patient compliance.
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