Medical application of functionalized magnetic nanoparticles

Ito, Akira; Shinkai, Masashige; Honda, Hiroyuki; Kobayashi, Takeshi

doi:10.1263/jbb.100.1

Cited by 1,329 publications

(716 citation statements)

References 78 publications

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“…Magnetic field has been used in various cellular applications, cell sorting, 3D cell cultures, tissue engineering, local hyperthermia therapies, and clinical imaging applications. [35][36][37][38] Using the droplet microarray method, free-standing hydrogels can be loaded with functional magnetic or other nanoparticles to enable the use of magnetic field for the remote manipulation of the hydrogels (Figure 4). Magnetic beads measuring 2 μm were added to alginate solution containing living Hela-GFP cells.…”

Section: Resultsmentioning

confidence: 99%

Fabrication of Hydrogel Particles of Defined Shapes Using Superhydrophobic‐Hydrophilic Micropatterns

et al. 2016

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We report a method to rapidly fabricate alginate hydrogel particles of specific sizes and shapes.Our method is based on the formation of arrays of droplets of pre-hydrogel solutions on superhydrophobic-hydrophilic patterns using the process of discontinuous dewetting, followed by their gelation via the parallel addition of CaCl 2 to the individual droplets via the sandwiching method. We demonstrate that viability of living cells incorporated within the hydrogel particles is higher during the long-term cultivation than in the case of cells cultured in the bulk threedimensional hydrogel matrix. Incorporation of magnetic particles into the free-standing hydrogel particles containing living cells enabled ease manipulation of the particles using an external magnetic field.

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Section: Resultsmentioning

confidence: 99%

Fabrication of Hydrogel Particles of Defined Shapes Using Superhydrophobic‐Hydrophilic Micropatterns

et al. 2016

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“…There have been a growing number of studies on magnetic nanoparticles (MNPs), due to their potential applications in nanomedicine, including targeted drug delivery, hyperthermia, magnetic resonance imaging (MRI), and biodetection [1][2][3] . In most of the applications, MNPs are required to possess non-toxicity, biocompatibility, mono-dispersity, stability in colloidal media, high magnetic moment, and freedom from remanent field.…”

Section: Introductionmentioning

confidence: 99%

Enhanced magnetic anisotropy and heating efficiency in multi-functional manganese ferrite/graphene oxide nanostructures

Giang

Tam

et al. 2016

Nanotechnology

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A promising nanocomposite material composed of MnFe2O4 (MFO) nanoparticles of ~17 nm diameter deposited onto graphene oxide (GO) nanosheets was successfully synthesized using a modified co-precipitation method. X-ray diffraction (XRD), transmission electron microscopy (TEM), and selected area electron diffraction (SAED) confirmed the quality of the synthesized samples. Fourier Transform Infrared (FTIR) measurements and analysis evidenced that the MFO nanoparticles were attached to the GO surface. Magnetic measurements and analysis using the modified Langevin model evidenced the superparamagnetic characteristic of both the bare MFO nanoparticles and the MFO-GO nanocomposite at room temperature, and an appreciable increase of the effective anisotropy for the MFO-GO sample. Magnetic hyperthermia experiments performed by both calorimetric and AC magnetometry methods indicated that relative to the bare MFO nanoparticles, the heating efficiency of the MFO-GO nanocomposite was similar at low ac fields (0-300 Oe) but became progressively larger with increasing ac fields (> 300 Oe). This has been related to the higher effective anisotropy of the MFO-GO nanocomposite. In comparison with the bare MFO nanoparticles, a smaller reduction in the heating efficiency was observed in the MFO-GO composites when MFO-GO were embedded in agar or when their concentration was increased, indicating that the GO helped minimize the physical rotation and aggregation of the MFO nanoparticles. These findings can be of practical importance in exploiting this type of nanocomposite for advanced hyperthermia. Magnetoimpedance-based biodetection studies also indicated that the MFO-GO nanocomposite could be used as a promising magnetic biomarker in biosensing applications.

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“…(4) where k, T,, η and d are the Boltzmann constant, an absolute temperature of a solution, a background electrolyte viscosity, and the particle diameter, respectively. The dimensionless parameter λ is a ratio of the particle cloud thickness (D/U) to the height of the channel w. (5) This parameter λ can be related to the retention ratio, R, defined as a measure of the average particle velocity along the channel compared to the average carrier velocity. (6) The retention ratio can be found from the ratio of void time and elution time.…”

Section: Micro Efff Theoretical Backgroundmentioning

confidence: 99%

“…Widely used nanoparticles for molecular diagnostics [2] are gold nanoparticles [3], quantum dots [4], and magnetic nanoparticles [5]. For the design and optimization of biochemical protocols using nanoparticles, a thorough characterization of their colloidal properties is necessary [6].…”

Section: Introductionmentioning

confidence: 99%

ζ-Potential analyses using micro-electrical field flow fractionation with fluorescent nanoparticles

Chang

Dosev

Kennedy

2007

Sensors and Actuators B: Chemical

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Increasingly growing application of nanoparticles in biotechnology requires fast and accessible tools for their manipulation and for characterization of their colloidal properties. In this work we determine the zeta-potentials for polystyrene nanoparticles using micro electrical field flow fractionation (μ-EFFF) which is an efficient method for sorting of particles by size. The data obtained by μ-EFFF were compared to zeta potentials determined by standard capillary electrophoresis. For proof of concept, we used polystyrene nanoparticles of two different sizes, impregnated with two different fluorescent dyes. Fluorescent emission spectra were used to evaluate the particle separation in both systems. Using the theory of electrophoresis, we estimated the zeta-potentials as a function of size, dielectric permittivity, viscosity and electrophoretic mobility. The results obtained by the μ-EFFF technique were confirmed by the conventional capillary electrophoresis measurements. These results demonstrate the applicability of the μ-EFFF method not only for particle size separation but also as a simple and inexpensive tool for measurements of nanoparticles zeta potentials.

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Medical application of functionalized magnetic nanoparticles

Cited by 1,329 publications

References 78 publications

Fabrication of Hydrogel Particles of Defined Shapes Using Superhydrophobic‐Hydrophilic Micropatterns

Fabrication of Hydrogel Particles of Defined Shapes Using Superhydrophobic‐Hydrophilic Micropatterns

Enhanced magnetic anisotropy and heating efficiency in multi-functional manganese ferrite/graphene oxide nanostructures

ζ-Potential analyses using micro-electrical field flow fractionation with fluorescent nanoparticles

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