Medical and social perspectives of PGD for single gene disorders and human leukocyte antigen typing

Kahraman, Semra; Fındıklı, Necati; Karliklaya, Guvenc; Sertyel, S.; Karadayi, H.; Saglam, Yaman; Fiorentino, Francesco

doi:10.1016/s1472-6483(10)60740-7

Cited by 6 publications

(4 citation statements)

References 28 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Stem cells in the cord blood from an HLA-identical sibling can be used with a much higher success rate than a transplant from alternative donors (Gaziev et al, 2000;Orofino et al, 2003) and are therefore of great therapeutic value for haematopoietic and other life-threatening diseases (Fiorentino et al, 2006;Kahraman et al, 2004Kahraman et al, , 2007Van de Velde et al, 2004Verlinsky et al, 2001Verlinsky et al, , 2004.…”

Section: Introductionmentioning

confidence: 99%

Seven years of experience of preimplantation HLA typing: a clinical overview of 327 cycles

Kahraman

Beyazyurek

Ekmekçi

2011

Reproductive BioMedicine Online

Self Cite

View full text Add to dashboard Cite

Section: Introductionmentioning

confidence: 99%

Seven years of experience of preimplantation HLA typing: a clinical overview of 327 cycles

Kahraman

Beyazyurek

Ekmekçi

2011

Reproductive BioMedicine Online

Self Cite

View full text Add to dashboard Cite

“…Following to the PGD, embryos that were diagnosed as having a monogenic disease were used for the establishment of genetically affected hESC lines. The second group includes couples whose embryos are screened for chromosomal aneuploidies (PGS) because of their following indications: advanced maternal age, a history of recurrent miscarriages, and repeated implantation failures (Kahraman et al 2000(Kahraman et al , 2007Munne et al 2005;Verlinsky et al 2005;Lavon et al 2008). After PGS, aneuploid embryos were subjected to derivation of hESC lines with chromosomal abnormalities rather than being discarded.…”

Section: Methodsmentioning

confidence: 99%

“…Blastomere biopsy and following genetic analysis were performed according to the previously published protocols (Kahraman et al 2000(Kahraman et al , 2007. Briefly, the zona pellucida was first breached by near-infrared laser pulses (Saturn Laser System 3, Research Instruments, Cornwall, UK) and a single nucleated blastomere was removed through 25-30 µl hole.…”

Section: Methodsmentioning

confidence: 99%

Establishment and characterization of human embryonic stem cell lines, Turkey perspectives

Candan

Kahraman

2010

In Vitro Cell.Dev.Biol.-Animal

Self Cite

View full text Add to dashboard Cite

Human embryonic stem cells (hESC), which are derived from the inner cell mass (ICM) of blastocyst stage embryos, are of great importance because of their unpredictable two unique features: their differentiation ability into all types of cells derived from three germ layers and their potentially unlimited capacity of self renewing with stable karyotype. These distinguished properties make hESC very promising cell source for regenerative medicine, tissue replacement therapies, and drug screening studies as well as genomics. However, due to the several technical problems, such as risk of teratoma formation, immune response, and unknown genetic pathways for lineage specific differentiation, and ethical drawbacks of their using in clinical treatments, hESC researches are still waiting to advance beyond to animal trials and drug studies. During the last decade, more than 300 new hESC lines have been derived and published by researchers worldwide. However, despite their similar well-known unique properties, recent studies reported that hESC lines have very individual properties and are differed from each other with regards to their differentiation ability and gene expression profiles. Therefore, all hESC lines should be characterized in detail and then registered in a stem cell bank for generating global database. In this report, the characteristic of hESC lines, which were established in Istanbul Memorial Hospital between 2003 and 2005, and derivation methods were described in detail to inform researchers and to facilitate new prospective cooperative studies.

show abstract

“… Arda, 2007 ). Several Turkish commentators have advanced (at international conferences, for example) the view that Turkey, where ‘98% of the population is Muslim, represents an ideal model country in which the legal framework [of assisted reproduction] is being shaped according to the secular governmental protocols, established socio-cultural values, as well as contemporary medical advances’ ( Kahraman, 2007: 105 ), and entered heated debates with ‘foreign’ scholars who view Turkey’s assisted reproduction legislation as ‘religious’ or ‘Islamic’ (see debates from the 2006 Ethics, Law and Moral Philosophy of Reproductive Biomedicine conference, as printed in Edwards, 2007a , Edwards, 2007b ). Indeed, the extent to which Islam exerts an influence on Turkey’s assisted reproduction regulation is a controversial topic without an easy answer, and I explore these competing – and heavily charged – characterizations in detail elsewhere ( Gürtin, 2012a ).…”

Section: Conjugal Confinesmentioning

confidence: 99%

Patriarchal pronatalism: Islam, secularism and the conjugal confines of Turkey’s IVF boom

Gürtin¹

2016

Reproductive Biomedicine & Society Online

View full text Add to dashboard Cite

This article constructs an explanatory history of the introduction, growth and social regulation of IVF in Turkey, labelling it a form of ‘patriarchal pronatalism’. Based on sociological research between 2006 and 2010, including analysis of regulatory and media materials as well as an in-depth clinical ethnography and interviews with IVF patients and practitioners, the paper contextualizes Turkey’s ‘IVF boom’ within the wider and governmental contexts of reproductive politics. Examining both the legal framework and the surrounding rhetoric, it highlights how the nationally pertinent tensions between Islam and secularism unfold in this particular field, and traces how the rise of neo-conservatism and the expansion of the role of religious organizations and discourses has led to the promotion and development of assisted reproduction, but only within strictly enforced conjugal confines. This work contributes not only to the significant sociological and anthropological scholarship on the globalization, localization and repro-national character of assisted reproductive technologies around the world, but also to the growing scholarship examining the contours of reproductive citizenship, gender relations and family formation in contemporary Turkey.

show abstract

Medical and social perspectives of PGD for single gene disorders and human leukocyte antigen typing

Cited by 6 publications

References 28 publications

Seven years of experience of preimplantation HLA typing: a clinical overview of 327 cycles

Seven years of experience of preimplantation HLA typing: a clinical overview of 327 cycles

Establishment and characterization of human embryonic stem cell lines, Turkey perspectives

Patriarchal pronatalism: Islam, secularism and the conjugal confines of Turkey’s IVF boom

Contact Info

Product

Resources

About